| Full name: glypican 6 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 13q31.3-q32.1 | ||
| Entrez ID: 10082 | HGNC ID: HGNC:4454 | Ensembl Gene: ENSG00000183098 | OMIM ID: 604404 |
| Drug and gene relationship at DGIdb | |||
Expression of GPC6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GPC6 | 10082 | 227059_at | -0.4716 | 0.7141 | |
| GSE26886 | GPC6 | 10082 | 223730_at | 0.1226 | 0.3225 | |
| GSE45670 | GPC6 | 10082 | 227059_at | -1.8509 | 0.0014 | |
| GSE53622 | GPC6 | 10082 | 32480 | 0.6635 | 0.0021 | |
| GSE53624 | GPC6 | 10082 | 68042 | 0.5960 | 0.0085 | |
| GSE63941 | GPC6 | 10082 | 223730_at | -1.9350 | 0.0000 | |
| GSE77861 | GPC6 | 10082 | 223730_at | -0.0329 | 0.7724 | |
| GSE97050 | GPC6 | 10082 | A_23_P371682 | 0.5113 | 0.1807 | |
| SRP007169 | GPC6 | 10082 | RNAseq | 4.8219 | 0.0000 | |
| SRP008496 | GPC6 | 10082 | RNAseq | 5.6610 | 0.0000 | |
| SRP064894 | GPC6 | 10082 | RNAseq | 1.2917 | 0.0043 | |
| SRP133303 | GPC6 | 10082 | RNAseq | 1.0405 | 0.0053 | |
| SRP159526 | GPC6 | 10082 | RNAseq | 0.5643 | 0.2051 | |
| SRP219564 | GPC6 | 10082 | RNAseq | 0.9664 | 0.2308 | |
| TCGA | GPC6 | 10082 | RNAseq | -0.3273 | 0.0782 |
Upregulated datasets: 4; Downregulated datasets: 2.
Survival by GPC6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GPC6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GPC6 | 10082 | 4 | 10 | 16 | |
| GSE20123 | GPC6 | 10082 | 4 | 9 | 17 | |
| GSE43470 | GPC6 | 10082 | 2 | 12 | 29 | |
| GSE46452 | GPC6 | 10082 | 0 | 32 | 27 | |
| GSE47630 | GPC6 | 10082 | 3 | 27 | 10 | |
| GSE54993 | GPC6 | 10082 | 11 | 3 | 56 | |
| GSE54994 | GPC6 | 10082 | 3 | 15 | 35 | |
| GSE60625 | GPC6 | 10082 | 0 | 3 | 8 | |
| GSE74703 | GPC6 | 10082 | 2 | 10 | 24 | |
| GSE74704 | GPC6 | 10082 | 2 | 9 | 9 | |
| TCGA | GPC6 | 10082 | 14 | 36 | 46 |
Total number of gains: 45; Total number of losses: 166; Total Number of normals: 277.
Somatic mutations of GPC6:
Generating mutation plots.
Highly correlated genes for GPC6:
Showing top 20/947 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GPC6 | SERPINF1 | 0.780595 | 5 | 0 | 5 |
| GPC6 | BICC1 | 0.779336 | 7 | 0 | 6 |
| GPC6 | MAPRE2 | 0.772959 | 4 | 0 | 4 |
| GPC6 | FAM155A | 0.770054 | 3 | 0 | 3 |
| GPC6 | ANXA6 | 0.768727 | 6 | 0 | 6 |
| GPC6 | TMEM176B | 0.754838 | 6 | 0 | 6 |
| GPC6 | NAP1L3 | 0.750827 | 6 | 0 | 5 |
| GPC6 | GYPC | 0.750344 | 4 | 0 | 4 |
| GPC6 | FKBP7 | 0.744011 | 6 | 0 | 6 |
| GPC6 | C1orf54 | 0.741616 | 6 | 0 | 6 |
| GPC6 | GDF6 | 0.741577 | 3 | 0 | 3 |
| GPC6 | HSD11B1 | 0.739728 | 6 | 0 | 5 |
| GPC6 | CPQ | 0.739135 | 5 | 0 | 5 |
| GPC6 | SVEP1 | 0.732031 | 6 | 0 | 6 |
| GPC6 | RGL1 | 0.731466 | 4 | 0 | 4 |
| GPC6 | TMEM176A | 0.729527 | 6 | 0 | 5 |
| GPC6 | A1BG | 0.728763 | 3 | 0 | 3 |
| GPC6 | CD163 | 0.727823 | 5 | 0 | 5 |
| GPC6 | TPP1 | 0.726282 | 4 | 0 | 3 |
| GPC6 | RAB8B | 0.726251 | 6 | 0 | 6 |
For details and further investigation, click here
