| Full name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 | Alias Symbol: SDR11E2 | ||
| Type: protein-coding gene | Cytoband: 1p12 | ||
| Entrez ID: 3284 | HGNC ID: HGNC:5218 | Ensembl Gene: ENSG00000203859 | OMIM ID: 613890 |
| Drug and gene relationship at DGIdb | |||
HSD3B2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04913 | Ovarian steroidogenesis |
Expression of HSD3B2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HSD3B2 | 3284 | 206294_at | 0.1098 | 0.5960 | |
| GSE20347 | HSD3B2 | 3284 | 206294_at | 0.0285 | 0.6667 | |
| GSE23400 | HSD3B2 | 3284 | 206294_at | -0.1040 | 0.0286 | |
| GSE26886 | HSD3B2 | 3284 | 206294_at | 0.2281 | 0.0654 | |
| GSE29001 | HSD3B2 | 3284 | 206294_at | -0.1593 | 0.3169 | |
| GSE38129 | HSD3B2 | 3284 | 206294_at | -0.0834 | 0.2030 | |
| GSE45670 | HSD3B2 | 3284 | 206294_at | 0.0326 | 0.7269 | |
| GSE53622 | HSD3B2 | 3284 | 25899 | 0.4263 | 0.0104 | |
| GSE53624 | HSD3B2 | 3284 | 25899 | 0.3796 | 0.0004 | |
| GSE63941 | HSD3B2 | 3284 | 206294_at | 0.0175 | 0.9133 | |
| GSE77861 | HSD3B2 | 3284 | 206294_at | -0.0867 | 0.3101 | |
| TCGA | HSD3B2 | 3284 | RNAseq | 0.6263 | 0.5650 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HSD3B2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HSD3B2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HSD3B2 | 3284 | 3 | 5 | 22 | |
| GSE20123 | HSD3B2 | 3284 | 4 | 5 | 21 | |
| GSE43470 | HSD3B2 | 3284 | 1 | 3 | 39 | |
| GSE46452 | HSD3B2 | 3284 | 2 | 1 | 56 | |
| GSE47630 | HSD3B2 | 3284 | 10 | 4 | 26 | |
| GSE54993 | HSD3B2 | 3284 | 0 | 2 | 68 | |
| GSE54994 | HSD3B2 | 3284 | 12 | 1 | 40 | |
| GSE60625 | HSD3B2 | 3284 | 0 | 0 | 11 | |
| GSE74703 | HSD3B2 | 3284 | 1 | 3 | 32 | |
| GSE74704 | HSD3B2 | 3284 | 2 | 3 | 15 | |
| TCGA | HSD3B2 | 3284 | 18 | 23 | 55 |
Total number of gains: 53; Total number of losses: 50; Total Number of normals: 385.
Somatic mutations of HSD3B2:
Generating mutation plots.
Highly correlated genes for HSD3B2:
Showing top 20/604 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HSD3B2 | ZBBX | 0.71146 | 3 | 0 | 3 |
| HSD3B2 | BMP15 | 0.705199 | 4 | 0 | 4 |
| HSD3B2 | OR10H3 | 0.697652 | 4 | 0 | 4 |
| HSD3B2 | EPOR | 0.686075 | 4 | 0 | 4 |
| HSD3B2 | IL1RAPL2 | 0.669548 | 5 | 0 | 5 |
| HSD3B2 | NOS1 | 0.667536 | 4 | 0 | 4 |
| HSD3B2 | HAND1 | 0.66312 | 4 | 0 | 4 |
| HSD3B2 | PRODH2 | 0.658051 | 4 | 0 | 4 |
| HSD3B2 | KCNH4 | 0.657135 | 4 | 0 | 4 |
| HSD3B2 | MTAP | 0.653989 | 5 | 0 | 4 |
| HSD3B2 | ABCG4 | 0.653979 | 3 | 0 | 3 |
| HSD3B2 | KLF1 | 0.65381 | 3 | 0 | 3 |
| HSD3B2 | TAS2R4 | 0.651793 | 5 | 0 | 5 |
| HSD3B2 | SLC5A7 | 0.64819 | 4 | 0 | 4 |
| HSD3B2 | DRD5 | 0.647168 | 4 | 0 | 3 |
| HSD3B2 | DISC1 | 0.646503 | 4 | 0 | 4 |
| HSD3B2 | KCNA4 | 0.646369 | 5 | 0 | 4 |
| HSD3B2 | GML | 0.646342 | 4 | 0 | 4 |
| HSD3B2 | KCNAB3 | 0.645894 | 5 | 0 | 4 |
| HSD3B2 | AMELY | 0.645036 | 4 | 0 | 4 |
For details and further investigation, click here
