ZC3H3

 

Full name: zinc finger CCCH-type containing 3 Alias Symbol: KIAA0150
Type: protein-coding gene Cytoband: 8q24.3
Entrez ID: 23144 HGNC ID: HGNC:28972 Ensembl Gene: ENSG00000014164 OMIM ID: 
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of ZC3H3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ZC3H3 23144 213445_at 0.7956 0.1411
GSE20347 ZC3H3 23144 213445_at 0.2885 0.0180
GSE23400 ZC3H3 23144 213445_at 0.1677 0.0018
GSE26886 ZC3H3 23144 213445_at 0.7244 0.0002
GSE29001 ZC3H3 23144 213445_at -0.1790 0.5773
GSE38129 ZC3H3 23144 213445_at 0.3044 0.0013
GSE45670 ZC3H3 23144 213445_at 0.2327 0.0396
GSE53622 ZC3H3 23144 22379 0.3424 0.0000
GSE53624 ZC3H3 23144 22379 0.4638 0.0000
GSE63941 ZC3H3 23144 213445_at 0.6967 0.0665
GSE77861 ZC3H3 23144 213445_at 0.1697 0.2127
GSE97050 ZC3H3 23144 A_33_P3423820 0.5869 0.1180
SRP007169 ZC3H3 23144 RNAseq -1.0170 0.0044
SRP008496 ZC3H3 23144 RNAseq -0.7044 0.0066
SRP064894 ZC3H3 23144 RNAseq 0.6010 0.0042
SRP133303 ZC3H3 23144 RNAseq 0.3112 0.0277
SRP159526 ZC3H3 23144 RNAseq 0.1108 0.5361
SRP193095 ZC3H3 23144 RNAseq 0.5107 0.0019
SRP219564 ZC3H3 23144 RNAseq 0.9202 0.0707
TCGA ZC3H3 23144 RNAseq 0.2362 0.0000

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by ZC3H3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ZC3H3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ZC3H3 23144 17 1 12
GSE20123 ZC3H3 23144 17 1 12
GSE43470 ZC3H3 23144 17 2 24
GSE46452 ZC3H3 23144 27 0 32
GSE47630 ZC3H3 23144 23 1 16
GSE54993 ZC3H3 23144 0 25 45
GSE54994 ZC3H3 23144 39 1 13
GSE60625 ZC3H3 23144 3 4 4
GSE74703 ZC3H3 23144 15 1 20
GSE74704 ZC3H3 23144 10 0 10
TCGA ZC3H3 23144 64 2 30

Total number of gains: 232; Total number of losses: 38; Total Number of normals: 218.  

 

Somatic mutations of ZC3H3:

 

Generating mutation plots.

 

Highly correlated genes for ZC3H3:

 

Showing top 20/1012 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ZC3H3C8orf760.810471404
ZC3H3B3GNT90.787024303
ZC3H3PTPN230.78117303
ZC3H3UTP230.762204404
ZC3H3LTV10.745745303
ZC3H3HSF10.74469411011
ZC3H3MTRR0.74263303
ZC3H3GAK0.739521404
ZC3H3COMMD50.736651504
ZC3H3PROSER10.734239303
ZC3H3NUP430.733823404
ZC3H3TMEM63B0.732596403
ZC3H3HS6ST10.727616303
ZC3H3NACC10.726565505
ZC3H3PHC20.723283303
ZC3H3PEX140.715322404
ZC3H3PLTP0.710776303
ZC3H3MXD30.709269505
ZC3H3SLC25A440.708843403
ZC3H3C8orf820.704899403

For details and further investigation, click here