| Full name: 5-hydroxytryptamine receptor 1B | Alias Symbol: S12|5-HT1B|HTR1D2|5-HT1DB | ||
| Type: protein-coding gene | Cytoband: 6q14.1 | ||
| Entrez ID: 3351 | HGNC ID: HGNC:5287 | Ensembl Gene: ENSG00000135312 | OMIM ID: 182131 |
| Drug and gene relationship at DGIdb | |||
HTR1B involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04024 | cAMP signaling pathway | |
| hsa04726 | Serotonergic synapse | |
| hsa04742 | Taste transduction |
Expression of HTR1B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HTR1B | 3351 | 210799_at | 0.0788 | 0.6954 | |
| GSE20347 | HTR1B | 3351 | 210799_at | 0.0786 | 0.4765 | |
| GSE23400 | HTR1B | 3351 | 210799_at | -0.1005 | 0.0307 | |
| GSE26886 | HTR1B | 3351 | 210799_at | -0.1254 | 0.3619 | |
| GSE29001 | HTR1B | 3351 | 210799_at | -0.1055 | 0.4577 | |
| GSE38129 | HTR1B | 3351 | 210799_at | -0.0609 | 0.4486 | |
| GSE45670 | HTR1B | 3351 | 210799_at | -0.0693 | 0.4738 | |
| GSE53622 | HTR1B | 3351 | 42450 | 0.0236 | 0.9077 | |
| GSE53624 | HTR1B | 3351 | 42450 | 0.2159 | 0.0079 | |
| GSE63941 | HTR1B | 3351 | 210799_at | 0.1946 | 0.3402 | |
| GSE77861 | HTR1B | 3351 | 210799_at | -0.0373 | 0.8127 | |
| GSE97050 | HTR1B | 3351 | A_23_P156824 | -0.4858 | 0.4466 | |
| TCGA | HTR1B | 3351 | RNAseq | -2.4011 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by HTR1B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HTR1B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HTR1B | 3351 | 1 | 4 | 25 | |
| GSE20123 | HTR1B | 3351 | 1 | 3 | 26 | |
| GSE43470 | HTR1B | 3351 | 2 | 0 | 41 | |
| GSE46452 | HTR1B | 3351 | 2 | 11 | 46 | |
| GSE47630 | HTR1B | 3351 | 8 | 4 | 28 | |
| GSE54993 | HTR1B | 3351 | 3 | 2 | 65 | |
| GSE54994 | HTR1B | 3351 | 8 | 6 | 39 | |
| GSE60625 | HTR1B | 3351 | 0 | 1 | 10 | |
| GSE74703 | HTR1B | 3351 | 2 | 0 | 34 | |
| GSE74704 | HTR1B | 3351 | 0 | 2 | 18 | |
| TCGA | HTR1B | 3351 | 7 | 22 | 67 |
Total number of gains: 34; Total number of losses: 55; Total Number of normals: 399.
Somatic mutations of HTR1B:
Generating mutation plots.
Highly correlated genes for HTR1B:
Showing top 20/417 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HTR1B | LINC00280 | 0.663992 | 3 | 0 | 3 |
| HTR1B | NFIA-AS2 | 0.659799 | 4 | 0 | 4 |
| HTR1B | HSD11B1L | 0.646013 | 3 | 0 | 3 |
| HTR1B | UBE2D4 | 0.639828 | 4 | 0 | 4 |
| HTR1B | P2RX1 | 0.639696 | 4 | 0 | 3 |
| HTR1B | OR2J2 | 0.633678 | 4 | 0 | 4 |
| HTR1B | CD5L | 0.631292 | 5 | 0 | 5 |
| HTR1B | PRPS1L1 | 0.62897 | 3 | 0 | 3 |
| HTR1B | ADAM30 | 0.627942 | 4 | 0 | 3 |
| HTR1B | CCDC177 | 0.627297 | 3 | 0 | 3 |
| HTR1B | LINC01278 | 0.627013 | 4 | 0 | 4 |
| HTR1B | HDAC11 | 0.625989 | 6 | 0 | 4 |
| HTR1B | CYP2D6 | 0.623987 | 6 | 0 | 4 |
| HTR1B | TBR1 | 0.616652 | 4 | 0 | 3 |
| HTR1B | ELK1 | 0.616535 | 4 | 0 | 3 |
| HTR1B | CGA | 0.614324 | 4 | 0 | 3 |
| HTR1B | RNF5 | 0.610982 | 6 | 0 | 4 |
| HTR1B | LINC00574 | 0.609814 | 5 | 0 | 4 |
| HTR1B | MAPK4 | 0.609684 | 4 | 0 | 4 |
| HTR1B | CDK18 | 0.609063 | 3 | 0 | 3 |
For details and further investigation, click here
