| Full name: 5-hydroxytryptamine receptor 3C | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 3q27.1 | ||
| Entrez ID: 170572 | HGNC ID: HGNC:24003 | Ensembl Gene: ENSG00000178084 | OMIM ID: 610121 |
| Drug and gene relationship at DGIdb | |||
HTR3C involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04726 | Serotonergic synapse | |
| hsa04742 | Taste transduction |
Expression of HTR3C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HTR3C | 170572 | 1553041_at | -0.1346 | 0.5751 | |
| GSE26886 | HTR3C | 170572 | 1553041_at | 0.0348 | 0.7527 | |
| GSE45670 | HTR3C | 170572 | 1553041_at | 0.0376 | 0.7103 | |
| GSE63941 | HTR3C | 170572 | 1553041_at | 0.2012 | 0.1551 | |
| GSE77861 | HTR3C | 170572 | 1553041_at | -0.2092 | 0.0165 | |
| TCGA | HTR3C | 170572 | RNAseq | -0.8667 | 0.4218 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HTR3C expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of HTR3C:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HTR3C | 170572 | 25 | 0 | 5 | |
| GSE20123 | HTR3C | 170572 | 25 | 0 | 5 | |
| GSE43470 | HTR3C | 170572 | 24 | 0 | 19 | |
| GSE46452 | HTR3C | 170572 | 19 | 1 | 39 | |
| GSE47630 | HTR3C | 170572 | 27 | 2 | 11 | |
| GSE54993 | HTR3C | 170572 | 1 | 19 | 50 | |
| GSE54994 | HTR3C | 170572 | 41 | 0 | 12 | |
| GSE60625 | HTR3C | 170572 | 0 | 6 | 5 | |
| GSE74703 | HTR3C | 170572 | 20 | 0 | 16 | |
| GSE74704 | HTR3C | 170572 | 17 | 0 | 3 | |
| TCGA | HTR3C | 170572 | 77 | 0 | 19 |
Total number of gains: 276; Total number of losses: 28; Total Number of normals: 184.
Somatic mutations of HTR3C:
Generating mutation plots.
Highly correlated genes for HTR3C:
Showing all 19 correlated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HTR3C | PAX8 | 0.671938 | 3 | 0 | 3 |
| HTR3C | CRLF2 | 0.665416 | 3 | 0 | 3 |
| HTR3C | CLYBL-AS1 | 0.654431 | 4 | 0 | 3 |
| HTR3C | CNGA3 | 0.653068 | 3 | 0 | 3 |
| HTR3C | LEMD1-AS1 | 0.641948 | 3 | 0 | 3 |
| HTR3C | OR52A1 | 0.606978 | 3 | 0 | 3 |
| HTR3C | CSMD1 | 0.605946 | 3 | 0 | 3 |
| HTR3C | ABCC8 | 0.591922 | 3 | 0 | 3 |
| HTR3C | P2RX1 | 0.590393 | 3 | 0 | 3 |
| HTR3C | NPY | 0.589114 | 3 | 0 | 3 |
| HTR3C | ZNF491 | 0.585505 | 3 | 0 | 3 |
| HTR3C | APOA1 | 0.581253 | 4 | 0 | 3 |
| HTR3C | TMEM72 | 0.578105 | 3 | 0 | 3 |
| HTR3C | STMN2 | 0.571727 | 3 | 0 | 3 |
| HTR3C | MACROD1 | 0.556954 | 3 | 0 | 3 |
| HTR3C | PRDX2 | 0.550413 | 3 | 0 | 3 |
| HTR3C | STAC2 | 0.540543 | 4 | 0 | 3 |
| HTR3C | LMNTD1 | 0.539571 | 4 | 0 | 3 |
| HTR3C | CST5 | 0.537826 | 4 | 0 | 3 |
For details and further investigation, click here
