| Full name: mono-ADP ribosylhydrolase 1 | Alias Symbol: LRP16 | ||
| Type: protein-coding gene | Cytoband: 11q13.1 | ||
| Entrez ID: 28992 | HGNC ID: HGNC:29598 | Ensembl Gene: ENSG00000133315 | OMIM ID: 610400 |
| Drug and gene relationship at DGIdb | |||
Expression of MACROD1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MACROD1 | 28992 | 219188_s_at | -0.2775 | 0.6107 | |
| GSE20347 | MACROD1 | 28992 | 219188_s_at | -0.3752 | 0.0616 | |
| GSE23400 | MACROD1 | 28992 | 219188_s_at | -0.2463 | 0.0013 | |
| GSE26886 | MACROD1 | 28992 | 219188_s_at | 0.4400 | 0.0385 | |
| GSE29001 | MACROD1 | 28992 | 219188_s_at | -0.6217 | 0.0175 | |
| GSE38129 | MACROD1 | 28992 | 219188_s_at | -0.3233 | 0.0372 | |
| GSE45670 | MACROD1 | 28992 | 219188_s_at | -0.2691 | 0.0638 | |
| GSE53622 | MACROD1 | 28992 | 25037 | -0.5075 | 0.0000 | |
| GSE53624 | MACROD1 | 28992 | 25037 | -0.4194 | 0.0000 | |
| GSE63941 | MACROD1 | 28992 | 219188_s_at | 1.6600 | 0.0047 | |
| GSE77861 | MACROD1 | 28992 | 219188_s_at | -0.3799 | 0.1201 | |
| GSE97050 | MACROD1 | 28992 | A_23_P86855 | -0.0934 | 0.7399 | |
| SRP007169 | MACROD1 | 28992 | RNAseq | -1.0809 | 0.0309 | |
| SRP008496 | MACROD1 | 28992 | RNAseq | -1.1226 | 0.0002 | |
| SRP064894 | MACROD1 | 28992 | RNAseq | -0.7205 | 0.0399 | |
| SRP133303 | MACROD1 | 28992 | RNAseq | -0.7167 | 0.0011 | |
| SRP159526 | MACROD1 | 28992 | RNAseq | -0.1663 | 0.6580 | |
| SRP193095 | MACROD1 | 28992 | RNAseq | -0.4052 | 0.0048 | |
| SRP219564 | MACROD1 | 28992 | RNAseq | -0.3012 | 0.3554 | |
| TCGA | MACROD1 | 28992 | RNAseq | -0.2835 | 0.0123 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by MACROD1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MACROD1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MACROD1 | 28992 | 6 | 5 | 19 | |
| GSE20123 | MACROD1 | 28992 | 6 | 5 | 19 | |
| GSE43470 | MACROD1 | 28992 | 1 | 3 | 39 | |
| GSE46452 | MACROD1 | 28992 | 8 | 4 | 47 | |
| GSE47630 | MACROD1 | 28992 | 3 | 7 | 30 | |
| GSE54993 | MACROD1 | 28992 | 3 | 0 | 67 | |
| GSE54994 | MACROD1 | 28992 | 5 | 5 | 43 | |
| GSE60625 | MACROD1 | 28992 | 0 | 4 | 7 | |
| GSE74703 | MACROD1 | 28992 | 1 | 1 | 34 | |
| GSE74704 | MACROD1 | 28992 | 4 | 3 | 13 | |
| TCGA | MACROD1 | 28992 | 18 | 10 | 68 |
Total number of gains: 55; Total number of losses: 47; Total Number of normals: 386.
Somatic mutations of MACROD1:
Generating mutation plots.
Highly correlated genes for MACROD1:
Showing top 20/104 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MACROD1 | RPL35 | 0.68872 | 3 | 0 | 3 |
| MACROD1 | IGSF11 | 0.659049 | 3 | 0 | 3 |
| MACROD1 | RNF126 | 0.654006 | 3 | 0 | 3 |
| MACROD1 | TPD52 | 0.638246 | 4 | 0 | 3 |
| MACROD1 | RPL12 | 0.633763 | 4 | 0 | 3 |
| MACROD1 | NR1H2 | 0.632254 | 4 | 0 | 3 |
| MACROD1 | LYPLA2 | 0.629109 | 3 | 0 | 3 |
| MACROD1 | RPS15 | 0.628661 | 4 | 0 | 3 |
| MACROD1 | R3HDM2 | 0.628427 | 4 | 0 | 4 |
| MACROD1 | CST5 | 0.623614 | 3 | 0 | 3 |
| MACROD1 | ZNF296 | 0.622905 | 3 | 0 | 3 |
| MACROD1 | TYSND1 | 0.622439 | 4 | 0 | 4 |
| MACROD1 | AAAS | 0.610572 | 6 | 0 | 4 |
| MACROD1 | MIF4GD | 0.608239 | 4 | 0 | 4 |
| MACROD1 | DNAJB7 | 0.6038 | 3 | 0 | 3 |
| MACROD1 | OIP5-AS1 | 0.600421 | 4 | 0 | 3 |
| MACROD1 | CHCHD5 | 0.600294 | 5 | 0 | 4 |
| MACROD1 | PNKD | 0.599286 | 3 | 0 | 3 |
| MACROD1 | LEMD1-AS1 | 0.596288 | 3 | 0 | 3 |
| MACROD1 | TFAP2A-AS1 | 0.574529 | 3 | 0 | 3 |
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