| Full name: intestinal cell kinase | Alias Symbol: MRK|LCK2|KIAA0936|MGC46090 | ||
| Type: protein-coding gene | Cytoband: 6p12.1 | ||
| Entrez ID: 22858 | HGNC ID: HGNC:21219 | Ensembl Gene: ENSG00000112144 | OMIM ID: 612325 |
| Drug and gene relationship at DGIdb | |||
Expression of ICK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ICK | 22858 | 204569_at | -0.0724 | 0.9183 | |
| GSE20347 | ICK | 22858 | 204569_at | 0.1193 | 0.6037 | |
| GSE23400 | ICK | 22858 | 204569_at | 0.1236 | 0.0222 | |
| GSE26886 | ICK | 22858 | 204569_at | 0.1254 | 0.7255 | |
| GSE29001 | ICK | 22858 | 204569_at | 0.0205 | 0.9566 | |
| GSE38129 | ICK | 22858 | 204569_at | 0.0832 | 0.5947 | |
| GSE45670 | ICK | 22858 | 204569_at | 0.1208 | 0.7033 | |
| GSE53622 | ICK | 22858 | 33412 | -0.4018 | 0.0005 | |
| GSE53624 | ICK | 22858 | 33412 | -0.1290 | 0.0946 | |
| GSE63941 | ICK | 22858 | 204569_at | -0.8695 | 0.1141 | |
| GSE77861 | ICK | 22858 | 204569_at | 0.5332 | 0.2823 | |
| GSE97050 | ICK | 22858 | A_23_P344988 | -0.4472 | 0.2943 | |
| TCGA | ICK | 22858 | RNAseq | -0.1155 | 0.1610 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ICK expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ICK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ICK | 22858 | 6 | 3 | 21 | |
| GSE20123 | ICK | 22858 | 7 | 2 | 21 | |
| GSE43470 | ICK | 22858 | 5 | 0 | 38 | |
| GSE46452 | ICK | 22858 | 2 | 10 | 47 | |
| GSE47630 | ICK | 22858 | 7 | 5 | 28 | |
| GSE54993 | ICK | 22858 | 3 | 1 | 66 | |
| GSE54994 | ICK | 22858 | 8 | 4 | 41 | |
| GSE60625 | ICK | 22858 | 0 | 3 | 8 | |
| GSE74703 | ICK | 22858 | 5 | 0 | 31 | |
| GSE74704 | ICK | 22858 | 3 | 1 | 16 | |
| TCGA | ICK | 22858 | 22 | 12 | 62 |
Total number of gains: 68; Total number of losses: 41; Total Number of normals: 379.
Somatic mutations of ICK:
Generating mutation plots.
Highly correlated genes for ICK:
Showing top 20/338 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ICK | NPAT | 0.776683 | 3 | 0 | 3 |
| ICK | PCGF6 | 0.775501 | 3 | 0 | 3 |
| ICK | SRI | 0.774217 | 3 | 0 | 3 |
| ICK | FUCA1 | 0.769554 | 3 | 0 | 3 |
| ICK | ARFIP1 | 0.764996 | 3 | 0 | 3 |
| ICK | PAIP1 | 0.756371 | 3 | 0 | 3 |
| ICK | RPA2 | 0.753834 | 3 | 0 | 3 |
| ICK | MFN1 | 0.734558 | 3 | 0 | 3 |
| ICK | HNRNPH3 | 0.731408 | 3 | 0 | 3 |
| ICK | SLITRK6 | 0.72969 | 3 | 0 | 3 |
| ICK | UBE4A | 0.716989 | 3 | 0 | 3 |
| ICK | KBTBD6 | 0.714545 | 3 | 0 | 3 |
| ICK | PON2 | 0.713033 | 4 | 0 | 3 |
| ICK | AP1AR | 0.708536 | 3 | 0 | 3 |
| ICK | BUD31 | 0.706707 | 4 | 0 | 4 |
| ICK | ZNF347 | 0.7039 | 3 | 0 | 3 |
| ICK | AGTPBP1 | 0.703709 | 3 | 0 | 3 |
| ICK | FAR2 | 0.702883 | 3 | 0 | 3 |
| ICK | CXorf40B | 0.701296 | 3 | 0 | 3 |
| ICK | AGGF1 | 0.697791 | 3 | 0 | 3 |
For details and further investigation, click here
