| Full name: paraoxonase 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 7q21.3 | ||
| Entrez ID: 5445 | HGNC ID: HGNC:9205 | Ensembl Gene: ENSG00000105854 | OMIM ID: 602447 |
| Drug and gene relationship at DGIdb | |||
Expression of PON2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PON2 | 5445 | 201876_at | 0.5065 | 0.0883 | |
| GSE20347 | PON2 | 5445 | 201876_at | 0.4865 | 0.0320 | |
| GSE23400 | PON2 | 5445 | 201876_at | 0.6431 | 0.0000 | |
| GSE26886 | PON2 | 5445 | 201876_at | 1.5696 | 0.0000 | |
| GSE29001 | PON2 | 5445 | 201876_at | 0.8245 | 0.0154 | |
| GSE38129 | PON2 | 5445 | 201876_at | 0.5883 | 0.0002 | |
| GSE45670 | PON2 | 5445 | 201876_at | 0.7408 | 0.0020 | |
| GSE53622 | PON2 | 5445 | 38210 | 0.7785 | 0.0000 | |
| GSE53624 | PON2 | 5445 | 38210 | 0.7793 | 0.0000 | |
| GSE63941 | PON2 | 5445 | 201876_at | -1.1013 | 0.0981 | |
| GSE77861 | PON2 | 5445 | 201876_at | 0.8065 | 0.0577 | |
| GSE97050 | PON2 | 5445 | A_23_P31399 | 0.2274 | 0.5824 | |
| SRP007169 | PON2 | 5445 | RNAseq | 0.5040 | 0.1526 | |
| SRP008496 | PON2 | 5445 | RNAseq | 1.1991 | 0.0000 | |
| SRP064894 | PON2 | 5445 | RNAseq | 0.9460 | 0.0000 | |
| SRP133303 | PON2 | 5445 | RNAseq | 1.2290 | 0.0000 | |
| SRP159526 | PON2 | 5445 | RNAseq | 0.6028 | 0.0472 | |
| SRP193095 | PON2 | 5445 | RNAseq | 0.7689 | 0.0004 | |
| SRP219564 | PON2 | 5445 | RNAseq | 0.7374 | 0.0850 | |
| TCGA | PON2 | 5445 | RNAseq | 0.2399 | 0.0032 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by PON2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PON2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PON2 | 5445 | 13 | 0 | 17 | |
| GSE20123 | PON2 | 5445 | 13 | 0 | 17 | |
| GSE43470 | PON2 | 5445 | 7 | 1 | 35 | |
| GSE46452 | PON2 | 5445 | 12 | 0 | 47 | |
| GSE47630 | PON2 | 5445 | 8 | 2 | 30 | |
| GSE54993 | PON2 | 5445 | 1 | 9 | 60 | |
| GSE54994 | PON2 | 5445 | 16 | 2 | 35 | |
| GSE60625 | PON2 | 5445 | 0 | 5 | 6 | |
| GSE74703 | PON2 | 5445 | 6 | 1 | 29 | |
| GSE74704 | PON2 | 5445 | 9 | 0 | 11 | |
| TCGA | PON2 | 5445 | 56 | 4 | 36 |
Total number of gains: 141; Total number of losses: 24; Total Number of normals: 323.
Somatic mutations of PON2:
Generating mutation plots.
Highly correlated genes for PON2:
Showing top 20/1345 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PON2 | PET117 | 0.797932 | 3 | 0 | 3 |
| PON2 | PPP6R3 | 0.790044 | 3 | 0 | 3 |
| PON2 | AURKAIP1 | 0.753256 | 3 | 0 | 3 |
| PON2 | WDR81 | 0.744394 | 3 | 0 | 3 |
| PON2 | TRIM47 | 0.742723 | 3 | 0 | 3 |
| PON2 | SLC38A7 | 0.73847 | 3 | 0 | 3 |
| PON2 | FADS1 | 0.728796 | 3 | 0 | 3 |
| PON2 | PRTFDC1 | 0.727386 | 5 | 0 | 5 |
| PON2 | HIC1 | 0.7267 | 3 | 0 | 3 |
| PON2 | KCNE3 | 0.724013 | 3 | 0 | 3 |
| PON2 | ICK | 0.713033 | 4 | 0 | 3 |
| PON2 | SEMA3A | 0.707157 | 4 | 0 | 3 |
| PON2 | NAF1 | 0.706835 | 4 | 0 | 4 |
| PON2 | C1orf226 | 0.705685 | 3 | 0 | 3 |
| PON2 | PDHX | 0.701936 | 3 | 0 | 3 |
| PON2 | CISD2 | 0.70066 | 3 | 0 | 3 |
| PON2 | RAB34 | 0.700365 | 3 | 0 | 3 |
| PON2 | C1orf115 | 0.697626 | 3 | 0 | 3 |
| PON2 | U2SURP | 0.69724 | 9 | 0 | 8 |
| PON2 | DHX37 | 0.696297 | 5 | 0 | 4 |
For details and further investigation, click here
