| Full name: nuclear protein, coactivator of histone transcription | Alias Symbol: E14|p220 | ||
| Type: protein-coding gene | Cytoband: 11q22.3 | ||
| Entrez ID: 4863 | HGNC ID: HGNC:7896 | Ensembl Gene: ENSG00000149308 | OMIM ID: 601448 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of NPAT:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NPAT | 4863 | 209798_at | -0.0781 | 0.8980 | |
| GSE20347 | NPAT | 4863 | 209798_at | 0.0090 | 0.9607 | |
| GSE23400 | NPAT | 4863 | 211584_s_at | -0.0527 | 0.1592 | |
| GSE26886 | NPAT | 4863 | 209798_at | 0.2086 | 0.3925 | |
| GSE29001 | NPAT | 4863 | 209798_at | 0.0849 | 0.7298 | |
| GSE38129 | NPAT | 4863 | 209798_at | -0.0242 | 0.8442 | |
| GSE45670 | NPAT | 4863 | 209798_at | -0.1930 | 0.1629 | |
| GSE53622 | NPAT | 4863 | 65178 | 0.0417 | 0.6664 | |
| GSE53624 | NPAT | 4863 | 65178 | 0.0150 | 0.9141 | |
| GSE63941 | NPAT | 4863 | 209798_at | -0.3561 | 0.4815 | |
| GSE77861 | NPAT | 4863 | 209798_at | 0.1632 | 0.6382 | |
| GSE97050 | NPAT | 4863 | A_23_P203013 | 0.2398 | 0.4062 | |
| SRP007169 | NPAT | 4863 | RNAseq | -0.1679 | 0.6074 | |
| SRP008496 | NPAT | 4863 | RNAseq | 0.1860 | 0.3430 | |
| SRP064894 | NPAT | 4863 | RNAseq | -0.1744 | 0.5012 | |
| SRP133303 | NPAT | 4863 | RNAseq | -0.0192 | 0.8956 | |
| SRP159526 | NPAT | 4863 | RNAseq | -0.1434 | 0.5445 | |
| SRP193095 | NPAT | 4863 | RNAseq | -0.2958 | 0.0000 | |
| SRP219564 | NPAT | 4863 | RNAseq | -0.3074 | 0.4362 | |
| TCGA | NPAT | 4863 | RNAseq | 0.0270 | 0.6155 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by NPAT expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NPAT:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NPAT | 4863 | 0 | 13 | 17 | |
| GSE20123 | NPAT | 4863 | 0 | 13 | 17 | |
| GSE43470 | NPAT | 4863 | 2 | 6 | 35 | |
| GSE46452 | NPAT | 4863 | 3 | 26 | 30 | |
| GSE47630 | NPAT | 4863 | 2 | 19 | 19 | |
| GSE54993 | NPAT | 4863 | 9 | 1 | 60 | |
| GSE54994 | NPAT | 4863 | 5 | 19 | 29 | |
| GSE60625 | NPAT | 4863 | 0 | 3 | 8 | |
| GSE74703 | NPAT | 4863 | 1 | 4 | 31 | |
| GSE74704 | NPAT | 4863 | 0 | 9 | 11 | |
| TCGA | NPAT | 4863 | 6 | 48 | 42 |
Total number of gains: 28; Total number of losses: 161; Total Number of normals: 299.
Somatic mutations of NPAT:
Generating mutation plots.
Highly correlated genes for NPAT:
Showing top 20/271 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NPAT | DOCK7 | 0.807836 | 3 | 0 | 3 |
| NPAT | RGS18 | 0.804721 | 3 | 0 | 3 |
| NPAT | NUP54 | 0.794138 | 3 | 0 | 3 |
| NPAT | ICK | 0.776683 | 3 | 0 | 3 |
| NPAT | RNF6 | 0.775794 | 3 | 0 | 3 |
| NPAT | WDFY1 | 0.756819 | 3 | 0 | 3 |
| NPAT | GIMAP8 | 0.756346 | 3 | 0 | 3 |
| NPAT | CCNC | 0.751892 | 3 | 0 | 3 |
| NPAT | LATS1 | 0.747526 | 3 | 0 | 3 |
| NPAT | MITD1 | 0.74716 | 3 | 0 | 3 |
| NPAT | NFKB1 | 0.745849 | 3 | 0 | 3 |
| NPAT | SFT2D3 | 0.740129 | 4 | 0 | 4 |
| NPAT | CD164 | 0.735302 | 3 | 0 | 3 |
| NPAT | SLC25A46 | 0.735086 | 3 | 0 | 3 |
| NPAT | FOPNL | 0.731744 | 3 | 0 | 3 |
| NPAT | ITFG1 | 0.726964 | 3 | 0 | 3 |
| NPAT | PIGB | 0.724615 | 4 | 0 | 4 |
| NPAT | ZBED5 | 0.72177 | 3 | 0 | 3 |
| NPAT | MAP3K8 | 0.720461 | 3 | 0 | 3 |
| NPAT | C6orf62 | 0.720169 | 3 | 0 | 3 |
For details and further investigation, click here
