| Full name: DENN domain containing 2C | Alias Symbol: FLJ37099|DKFZp686G0351|DKFZp779P1149|dJ1156J9.1|RP5-1156J9.1 | ||
| Type: protein-coding gene | Cytoband: 1p13.2 | ||
| Entrez ID: 163259 | HGNC ID: HGNC:24748 | Ensembl Gene: ENSG00000175984 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of DENND2C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DENND2C | 163259 | 230769_at | -1.3664 | 0.2180 | |
| GSE26886 | DENND2C | 163259 | 230769_at | -3.4386 | 0.0000 | |
| GSE45670 | DENND2C | 163259 | 230769_at | -0.5924 | 0.0264 | |
| GSE53622 | DENND2C | 163259 | 17907 | -0.8834 | 0.0000 | |
| GSE53624 | DENND2C | 163259 | 17907 | -1.0028 | 0.0000 | |
| GSE63941 | DENND2C | 163259 | 230769_at | 0.8396 | 0.4279 | |
| GSE77861 | DENND2C | 163259 | 230769_at | -1.2666 | 0.0003 | |
| GSE97050 | DENND2C | 163259 | A_24_P6467 | -0.4204 | 0.4762 | |
| SRP007169 | DENND2C | 163259 | RNAseq | -2.6500 | 0.0000 | |
| SRP008496 | DENND2C | 163259 | RNAseq | -2.8606 | 0.0000 | |
| SRP064894 | DENND2C | 163259 | RNAseq | -2.6143 | 0.0000 | |
| SRP133303 | DENND2C | 163259 | RNAseq | -1.7319 | 0.0000 | |
| SRP159526 | DENND2C | 163259 | RNAseq | -2.5585 | 0.0000 | |
| SRP193095 | DENND2C | 163259 | RNAseq | -1.9312 | 0.0000 | |
| SRP219564 | DENND2C | 163259 | RNAseq | -2.4796 | 0.0123 | |
| TCGA | DENND2C | 163259 | RNAseq | 0.4676 | 0.0040 |
Upregulated datasets: 0; Downregulated datasets: 10.
Survival by DENND2C expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DENND2C:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DENND2C | 163259 | 0 | 9 | 21 | |
| GSE20123 | DENND2C | 163259 | 0 | 9 | 21 | |
| GSE43470 | DENND2C | 163259 | 0 | 8 | 35 | |
| GSE46452 | DENND2C | 163259 | 2 | 1 | 56 | |
| GSE47630 | DENND2C | 163259 | 9 | 5 | 26 | |
| GSE54993 | DENND2C | 163259 | 0 | 1 | 69 | |
| GSE54994 | DENND2C | 163259 | 7 | 3 | 43 | |
| GSE60625 | DENND2C | 163259 | 0 | 0 | 11 | |
| GSE74703 | DENND2C | 163259 | 0 | 7 | 29 | |
| GSE74704 | DENND2C | 163259 | 0 | 5 | 15 | |
| TCGA | DENND2C | 163259 | 12 | 30 | 54 |
Total number of gains: 30; Total number of losses: 78; Total Number of normals: 380.
Somatic mutations of DENND2C:
Generating mutation plots.
Highly correlated genes for DENND2C:
Showing top 20/1321 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DENND2C | NIPAL1 | 0.831238 | 3 | 0 | 3 |
| DENND2C | TMEM40 | 0.828723 | 8 | 0 | 8 |
| DENND2C | CAPN14 | 0.820105 | 6 | 0 | 6 |
| DENND2C | EPGN | 0.818248 | 3 | 0 | 3 |
| DENND2C | TTC9 | 0.816718 | 7 | 0 | 7 |
| DENND2C | FAM3D | 0.813818 | 7 | 0 | 7 |
| DENND2C | CLIC3 | 0.808714 | 6 | 0 | 6 |
| DENND2C | TMEM154 | 0.805089 | 8 | 0 | 8 |
| DENND2C | PSCA | 0.803356 | 4 | 0 | 4 |
| DENND2C | C1orf116 | 0.80185 | 8 | 0 | 8 |
| DENND2C | A2ML1 | 0.797222 | 8 | 0 | 8 |
| DENND2C | TTC22 | 0.792658 | 7 | 0 | 7 |
| DENND2C | TRIP10 | 0.791153 | 7 | 0 | 7 |
| DENND2C | TMOD3 | 0.790002 | 8 | 0 | 7 |
| DENND2C | EPB41L4A | 0.788746 | 5 | 0 | 5 |
| DENND2C | S100A16 | 0.788629 | 8 | 0 | 8 |
| DENND2C | C15orf62 | 0.78727 | 7 | 0 | 7 |
| DENND2C | SUCLG2 | 0.784815 | 3 | 0 | 3 |
| DENND2C | ZNF185 | 0.784269 | 8 | 0 | 8 |
| DENND2C | MAPK3 | 0.78313 | 7 | 0 | 7 |
For details and further investigation, click here
