LPAR5

 

Full name: lysophosphatidic acid receptor 5 Alias Symbol: KPG_010|LPA5
Type: protein-coding gene Cytoband: 12p13.31
Entrez ID: 57121 HGNC ID: HGNC:13307 Ensembl Gene: ENSG00000184574 OMIM ID: 606926
Drug and gene relationship at DGIdb

 

LPAR5 involved pathways:

KEGG pathway Description View
hsa04015Rap1 signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04151PI3K-Akt signaling pathway

 

Expression of LPAR5:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 LPAR5 57121 230252_at -0.9119 0.3685
GSE26886 LPAR5 57121 230252_at -1.4770 0.0001
GSE45670 LPAR5 57121 230252_at 0.0277 0.9267
GSE53622 LPAR5 57121 28859 -0.8255 0.0000
GSE53624 LPAR5 57121 28859 -1.0780 0.0000
GSE63941 LPAR5 57121 230252_at 2.7534 0.0061
GSE77861 LPAR5 57121 230252_at -0.4753 0.3799
GSE97050 LPAR5 57121 A_23_P204375 0.4927 0.6284
SRP007169 LPAR5 57121 RNAseq -1.3246 0.0001
SRP008496 LPAR5 57121 RNAseq -1.3332 0.0000
SRP064894 LPAR5 57121 RNAseq -1.0802 0.0000
SRP133303 LPAR5 57121 RNAseq -1.0785 0.0000
SRP159526 LPAR5 57121 RNAseq -1.8731 0.0033
SRP193095 LPAR5 57121 RNAseq -1.0042 0.0000
SRP219564 LPAR5 57121 RNAseq -1.5194 0.0422
TCGA LPAR5 57121 RNAseq 0.0152 0.9064

Upregulated datasets: 1; Downregulated datasets: 9.  

 

Survival by LPAR5 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of LPAR5:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 LPAR5 57121 9 4 17
GSE20123 LPAR5 57121 9 4 17
GSE43470 LPAR5 57121 8 3 32
GSE46452 LPAR5 57121 10 1 48
GSE47630 LPAR5 57121 12 2 26
GSE54993 LPAR5 57121 1 10 59
GSE54994 LPAR5 57121 10 2 41
GSE60625 LPAR5 57121 0 1 10
GSE74703 LPAR5 57121 7 2 27
GSE74704 LPAR5 57121 5 3 12
TCGA LPAR5 57121 40 6 50

Total number of gains: 111; Total number of losses: 38; Total Number of normals: 339.  

 

Somatic mutations of LPAR5:

 

Generating mutation plots.

 

Highly correlated genes for LPAR5:

 

Showing top 20/891 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
LPAR5ARAP20.76214303
LPAR5PPP1R13L0.749956505
LPAR5CKMT1A0.744254303
LPAR5CERS30.740091606
LPAR5DSC20.73856807
LPAR5NIPAL10.730943303
LPAR5CTNND10.727865303
LPAR5DUOXA10.724296706
LPAR5KRT750.719831303
LPAR5SLC9A3R10.719256807
LPAR5NUAK20.716343303
LPAR5SERPINB50.715334807
LPAR5GJB50.714999707
LPAR5CDCP10.713207505
LPAR5CDA0.710512605
LPAR5DHRS10.710476505
LPAR5ADH70.708129605
LPAR5FAM160A10.707423606
LPAR5ELOVL10.702887404
LPAR5PGLYRP30.702845404

For details and further investigation, click here