| Full name: interferon induced transmembrane protein 3 | Alias Symbol: 1-8U|DSPA2b | ||
| Type: protein-coding gene | Cytoband: 11p15.5 | ||
| Entrez ID: 10410 | HGNC ID: HGNC:5414 | Ensembl Gene: ENSG00000142089 | OMIM ID: 605579 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of IFITM3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IFITM3 | 10410 | 212203_x_at | 0.2480 | 0.6041 | |
| GSE20347 | IFITM3 | 10410 | 212203_x_at | 0.9116 | 0.0001 | |
| GSE23400 | IFITM3 | 10410 | 212203_x_at | 0.7750 | 0.0000 | |
| GSE26886 | IFITM3 | 10410 | 212203_x_at | 1.2131 | 0.0141 | |
| GSE29001 | IFITM3 | 10410 | 212203_x_at | 0.9368 | 0.0049 | |
| GSE38129 | IFITM3 | 10410 | 212203_x_at | 0.5691 | 0.0553 | |
| GSE45670 | IFITM3 | 10410 | 212203_x_at | 0.5524 | 0.0738 | |
| GSE53622 | IFITM3 | 10410 | 37769 | 1.0297 | 0.0000 | |
| GSE53624 | IFITM3 | 10410 | 37769 | 1.2494 | 0.0000 | |
| GSE63941 | IFITM3 | 10410 | 212203_x_at | -0.3377 | 0.7221 | |
| GSE77861 | IFITM3 | 10410 | 212203_x_at | 0.8618 | 0.0175 | |
| GSE97050 | IFITM3 | 10410 | A_23_P87545 | 1.1682 | 0.0620 | |
| SRP007169 | IFITM3 | 10410 | RNAseq | 2.6947 | 0.0000 | |
| SRP008496 | IFITM3 | 10410 | RNAseq | 2.2502 | 0.0000 | |
| SRP064894 | IFITM3 | 10410 | RNAseq | 1.6891 | 0.0000 | |
| SRP133303 | IFITM3 | 10410 | RNAseq | 0.5881 | 0.0179 | |
| SRP159526 | IFITM3 | 10410 | RNAseq | 0.1170 | 0.7899 | |
| SRP193095 | IFITM3 | 10410 | RNAseq | 1.7180 | 0.0000 | |
| SRP219564 | IFITM3 | 10410 | RNAseq | 0.8168 | 0.1750 | |
| TCGA | IFITM3 | 10410 | RNAseq | 0.2943 | 0.0001 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by IFITM3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IFITM3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IFITM3 | 10410 | 1 | 11 | 18 | |
| GSE20123 | IFITM3 | 10410 | 1 | 12 | 17 | |
| GSE43470 | IFITM3 | 10410 | 1 | 10 | 32 | |
| GSE46452 | IFITM3 | 10410 | 7 | 8 | 44 | |
| GSE47630 | IFITM3 | 10410 | 4 | 12 | 24 | |
| GSE54993 | IFITM3 | 10410 | 3 | 2 | 65 | |
| GSE54994 | IFITM3 | 10410 | 1 | 12 | 40 | |
| GSE60625 | IFITM3 | 10410 | 0 | 0 | 11 | |
| GSE74703 | IFITM3 | 10410 | 1 | 8 | 27 | |
| GSE74704 | IFITM3 | 10410 | 0 | 8 | 12 | |
| TCGA | IFITM3 | 10410 | 8 | 38 | 50 |
Total number of gains: 27; Total number of losses: 121; Total Number of normals: 340.
Somatic mutations of IFITM3:
Generating mutation plots.
Highly correlated genes for IFITM3:
Showing top 20/1598 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IFITM3 | IFITM2 | 0.938453 | 13 | 0 | 13 |
| IFITM3 | IFITM1 | 0.884912 | 11 | 0 | 11 |
| IFITM3 | LRRC8C | 0.7595 | 3 | 0 | 3 |
| IFITM3 | GNG10 | 0.74476 | 3 | 0 | 3 |
| IFITM3 | IFI35 | 0.739243 | 13 | 0 | 13 |
| IFITM3 | MSN | 0.733074 | 12 | 0 | 11 |
| IFITM3 | IFI6 | 0.728976 | 13 | 0 | 13 |
| IFITM3 | ZNFX1 | 0.727044 | 9 | 0 | 9 |
| IFITM3 | ARPC1B | 0.725924 | 11 | 0 | 10 |
| IFITM3 | YWHAH | 0.72311 | 10 | 0 | 10 |
| IFITM3 | CALU | 0.721224 | 10 | 0 | 10 |
| IFITM3 | CD80 | 0.719772 | 3 | 0 | 3 |
| IFITM3 | LGALS1 | 0.71697 | 11 | 0 | 11 |
| IFITM3 | USP41 | 0.710008 | 3 | 0 | 3 |
| IFITM3 | FADS1 | 0.709816 | 3 | 0 | 3 |
| IFITM3 | SPON2 | 0.709621 | 3 | 0 | 3 |
| IFITM3 | RAB34 | 0.708909 | 3 | 0 | 3 |
| IFITM3 | ZFAND3 | 0.706877 | 3 | 0 | 3 |
| IFITM3 | EGFL7 | 0.7064 | 3 | 0 | 3 |
| IFITM3 | FBLIM1 | 0.705863 | 6 | 0 | 6 |
For details and further investigation, click here
