| Full name: insulin like growth factor binding protein 6 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12q13.13 | ||
| Entrez ID: 3489 | HGNC ID: HGNC:5475 | Ensembl Gene: ENSG00000167779 | OMIM ID: 146735 |
| Drug and gene relationship at DGIdb | |||
Expression of IGFBP6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IGFBP6 | 3489 | 203851_at | -0.4858 | 0.7483 | |
| GSE20347 | IGFBP6 | 3489 | 203851_at | 0.5051 | 0.3288 | |
| GSE23400 | IGFBP6 | 3489 | 203851_at | -0.2547 | 0.3254 | |
| GSE26886 | IGFBP6 | 3489 | 203851_at | 0.7085 | 0.2682 | |
| GSE29001 | IGFBP6 | 3489 | 203851_at | 1.5917 | 0.0537 | |
| GSE38129 | IGFBP6 | 3489 | 203851_at | -0.4244 | 0.4250 | |
| GSE45670 | IGFBP6 | 3489 | 203851_at | -0.2861 | 0.7283 | |
| GSE53622 | IGFBP6 | 3489 | 8666 | 0.0781 | 0.7834 | |
| GSE53624 | IGFBP6 | 3489 | 8666 | 0.6773 | 0.0023 | |
| GSE63941 | IGFBP6 | 3489 | 203851_at | -3.0785 | 0.0388 | |
| GSE77861 | IGFBP6 | 3489 | 203851_at | 1.0006 | 0.2928 | |
| GSE97050 | IGFBP6 | 3489 | A_23_P139912 | -0.4783 | 0.5593 | |
| SRP007169 | IGFBP6 | 3489 | RNAseq | 3.8065 | 0.0001 | |
| SRP008496 | IGFBP6 | 3489 | RNAseq | 3.1525 | 0.0003 | |
| SRP064894 | IGFBP6 | 3489 | RNAseq | -0.1113 | 0.8369 | |
| SRP133303 | IGFBP6 | 3489 | RNAseq | 0.9925 | 0.0872 | |
| SRP159526 | IGFBP6 | 3489 | RNAseq | -1.5384 | 0.0032 | |
| SRP219564 | IGFBP6 | 3489 | RNAseq | 1.0362 | 0.1989 | |
| TCGA | IGFBP6 | 3489 | RNAseq | -0.2469 | 0.1434 |
Upregulated datasets: 2; Downregulated datasets: 2.
Survival by IGFBP6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IGFBP6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IGFBP6 | 3489 | 8 | 1 | 21 | |
| GSE20123 | IGFBP6 | 3489 | 8 | 1 | 21 | |
| GSE43470 | IGFBP6 | 3489 | 3 | 0 | 40 | |
| GSE46452 | IGFBP6 | 3489 | 7 | 1 | 51 | |
| GSE47630 | IGFBP6 | 3489 | 10 | 2 | 28 | |
| GSE54993 | IGFBP6 | 3489 | 0 | 5 | 65 | |
| GSE54994 | IGFBP6 | 3489 | 4 | 1 | 48 | |
| GSE60625 | IGFBP6 | 3489 | 0 | 0 | 11 | |
| GSE74703 | IGFBP6 | 3489 | 3 | 0 | 33 | |
| GSE74704 | IGFBP6 | 3489 | 5 | 1 | 14 | |
| TCGA | IGFBP6 | 3489 | 13 | 11 | 72 |
Total number of gains: 61; Total number of losses: 23; Total Number of normals: 404.
Somatic mutations of IGFBP6:
Generating mutation plots.
Highly correlated genes for IGFBP6:
Showing top 20/518 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IGFBP6 | CDS2 | 0.751174 | 3 | 0 | 3 |
| IGFBP6 | IRS2 | 0.732058 | 3 | 0 | 3 |
| IGFBP6 | TBC1D19 | 0.729557 | 3 | 0 | 3 |
| IGFBP6 | TBC1D8B | 0.719366 | 3 | 0 | 3 |
| IGFBP6 | NMT2 | 0.717888 | 4 | 0 | 4 |
| IGFBP6 | IL17RD | 0.713109 | 3 | 0 | 3 |
| IGFBP6 | TRIM47 | 0.71183 | 3 | 0 | 3 |
| IGFBP6 | RASSF3 | 0.708716 | 3 | 0 | 3 |
| IGFBP6 | CC2D2A | 0.707214 | 4 | 0 | 4 |
| IGFBP6 | RASSF8 | 0.705519 | 3 | 0 | 3 |
| IGFBP6 | PDK3 | 0.703188 | 3 | 0 | 3 |
| IGFBP6 | STAT5A | 0.700444 | 3 | 0 | 3 |
| IGFBP6 | SGTB | 0.699099 | 4 | 0 | 3 |
| IGFBP6 | HNRNPUL2 | 0.694801 | 3 | 0 | 3 |
| IGFBP6 | DOCK11 | 0.690995 | 6 | 0 | 4 |
| IGFBP6 | CLIP2 | 0.683934 | 3 | 0 | 3 |
| IGFBP6 | UXS1 | 0.679817 | 3 | 0 | 3 |
| IGFBP6 | INPP4A | 0.676997 | 3 | 0 | 3 |
| IGFBP6 | MCAM | 0.676533 | 9 | 0 | 8 |
| IGFBP6 | EPB41L2 | 0.675545 | 4 | 0 | 3 |
For details and further investigation, click here
