| Full name: immunoglobulin superfamily member 6 | Alias Symbol: DORA | ||
| Type: protein-coding gene | Cytoband: 16p12.2 | ||
| Entrez ID: 10261 | HGNC ID: HGNC:5953 | Ensembl Gene: ENSG00000140749 | OMIM ID: 606222 |
| Drug and gene relationship at DGIdb | |||
Expression of IGSF6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IGSF6 | 10261 | 206420_at | 1.3949 | 0.1374 | |
| GSE20347 | IGSF6 | 10261 | 206420_at | 0.2164 | 0.0916 | |
| GSE23400 | IGSF6 | 10261 | 206420_at | 0.0487 | 0.1116 | |
| GSE26886 | IGSF6 | 10261 | 206420_at | 0.1960 | 0.6081 | |
| GSE29001 | IGSF6 | 10261 | 206420_at | 0.7735 | 0.0165 | |
| GSE38129 | IGSF6 | 10261 | 206420_at | 0.7448 | 0.0084 | |
| GSE45670 | IGSF6 | 10261 | 206420_at | 0.4045 | 0.2940 | |
| GSE53622 | IGSF6 | 10261 | 34030 | 0.9856 | 0.0000 | |
| GSE53624 | IGSF6 | 10261 | 34030 | 1.0568 | 0.0000 | |
| GSE63941 | IGSF6 | 10261 | 206420_at | 0.0727 | 0.4867 | |
| GSE77861 | IGSF6 | 10261 | 206420_at | -0.0529 | 0.5301 | |
| GSE97050 | IGSF6 | 10261 | A_33_P3372004 | 0.7956 | 0.0959 | |
| SRP007169 | IGSF6 | 10261 | RNAseq | 1.9906 | 0.0074 | |
| SRP008496 | IGSF6 | 10261 | RNAseq | 1.6880 | 0.0008 | |
| SRP064894 | IGSF6 | 10261 | RNAseq | 1.2009 | 0.0000 | |
| SRP133303 | IGSF6 | 10261 | RNAseq | 0.7979 | 0.0000 | |
| SRP159526 | IGSF6 | 10261 | RNAseq | 0.5623 | 0.3818 | |
| SRP193095 | IGSF6 | 10261 | RNAseq | 0.3843 | 0.0008 | |
| SRP219564 | IGSF6 | 10261 | RNAseq | 1.2997 | 0.0218 | |
| TCGA | IGSF6 | 10261 | RNAseq | 0.7557 | 0.0000 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by IGSF6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IGSF6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IGSF6 | 10261 | 6 | 3 | 21 | |
| GSE20123 | IGSF6 | 10261 | 6 | 2 | 22 | |
| GSE43470 | IGSF6 | 10261 | 3 | 3 | 37 | |
| GSE46452 | IGSF6 | 10261 | 38 | 1 | 20 | |
| GSE47630 | IGSF6 | 10261 | 11 | 6 | 23 | |
| GSE54993 | IGSF6 | 10261 | 3 | 5 | 62 | |
| GSE54994 | IGSF6 | 10261 | 4 | 10 | 39 | |
| GSE60625 | IGSF6 | 10261 | 4 | 0 | 7 | |
| GSE74703 | IGSF6 | 10261 | 3 | 2 | 31 | |
| GSE74704 | IGSF6 | 10261 | 3 | 1 | 16 | |
| TCGA | IGSF6 | 10261 | 19 | 13 | 64 |
Total number of gains: 100; Total number of losses: 46; Total Number of normals: 342.
Somatic mutations of IGSF6:
Generating mutation plots.
Highly correlated genes for IGSF6:
Showing top 20/671 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IGSF6 | FCGR3A | 0.873832 | 3 | 0 | 3 |
| IGSF6 | HAVCR2 | 0.769448 | 5 | 0 | 4 |
| IGSF6 | GPR141 | 0.765582 | 3 | 0 | 3 |
| IGSF6 | PDE7A | 0.760639 | 3 | 0 | 3 |
| IGSF6 | CERKL | 0.751907 | 3 | 0 | 3 |
| IGSF6 | FCER1G | 0.747586 | 10 | 0 | 9 |
| IGSF6 | ARHGAP18 | 0.746343 | 5 | 0 | 5 |
| IGSF6 | TYROBP | 0.745321 | 11 | 0 | 10 |
| IGSF6 | PDCD1LG2 | 0.741757 | 3 | 0 | 3 |
| IGSF6 | MED10 | 0.740916 | 3 | 0 | 3 |
| IGSF6 | LCP2 | 0.740831 | 9 | 0 | 8 |
| IGSF6 | PLA2G7 | 0.740475 | 11 | 0 | 10 |
| IGSF6 | ERGIC3 | 0.73978 | 4 | 0 | 3 |
| IGSF6 | C19orf38 | 0.734756 | 3 | 0 | 3 |
| IGSF6 | HNRNPL | 0.73423 | 3 | 0 | 3 |
| IGSF6 | ARFRP1 | 0.731317 | 3 | 0 | 3 |
| IGSF6 | C1QB | 0.727841 | 11 | 0 | 10 |
| IGSF6 | TMCO6 | 0.727049 | 3 | 0 | 3 |
| IGSF6 | LRRC8C | 0.726306 | 3 | 0 | 3 |
| IGSF6 | MNDA | 0.720521 | 10 | 0 | 10 |
For details and further investigation, click here
