| Full name: kelch like family member 7 | Alias Symbol: KLHL6|SBBI26|RP42 | ||
| Type: protein-coding gene | Cytoband: 7p15.3 | ||
| Entrez ID: 55975 | HGNC ID: HGNC:15646 | Ensembl Gene: ENSG00000122550 | OMIM ID: 611119 |
| Drug and gene relationship at DGIdb | |||
Expression of KLHL7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KLHL7 | 55975 | 223250_at | 0.2246 | 0.7175 | |
| GSE20347 | KLHL7 | 55975 | 220239_at | 1.2337 | 0.0006 | |
| GSE23400 | KLHL7 | 55975 | 220239_at | 0.5685 | 0.0000 | |
| GSE26886 | KLHL7 | 55975 | 223250_at | 1.1105 | 0.0001 | |
| GSE29001 | KLHL7 | 55975 | 220239_at | 0.9183 | 0.0190 | |
| GSE38129 | KLHL7 | 55975 | 220239_at | 1.6383 | 0.0000 | |
| GSE45670 | KLHL7 | 55975 | 223250_at | 0.1141 | 0.5279 | |
| GSE53622 | KLHL7 | 55975 | 8827 | 0.7045 | 0.0000 | |
| GSE53624 | KLHL7 | 55975 | 8827 | 0.5176 | 0.0000 | |
| GSE63941 | KLHL7 | 55975 | 223250_at | -0.8869 | 0.0402 | |
| GSE77861 | KLHL7 | 55975 | 223250_at | 0.4612 | 0.1467 | |
| GSE97050 | KLHL7 | 55975 | A_23_P324994 | 0.3124 | 0.4092 | |
| SRP007169 | KLHL7 | 55975 | RNAseq | 0.4062 | 0.2227 | |
| SRP008496 | KLHL7 | 55975 | RNAseq | 1.2054 | 0.0000 | |
| SRP064894 | KLHL7 | 55975 | RNAseq | 0.4595 | 0.0383 | |
| SRP133303 | KLHL7 | 55975 | RNAseq | 0.6416 | 0.0000 | |
| SRP159526 | KLHL7 | 55975 | RNAseq | 0.5081 | 0.0159 | |
| SRP193095 | KLHL7 | 55975 | RNAseq | 0.3585 | 0.0030 | |
| SRP219564 | KLHL7 | 55975 | RNAseq | 0.1987 | 0.6093 | |
| TCGA | KLHL7 | 55975 | RNAseq | 0.1861 | 0.0007 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by KLHL7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KLHL7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KLHL7 | 55975 | 17 | 1 | 12 | |
| GSE20123 | KLHL7 | 55975 | 17 | 1 | 12 | |
| GSE43470 | KLHL7 | 55975 | 4 | 0 | 39 | |
| GSE46452 | KLHL7 | 55975 | 10 | 2 | 47 | |
| GSE47630 | KLHL7 | 55975 | 9 | 1 | 30 | |
| GSE54993 | KLHL7 | 55975 | 0 | 6 | 64 | |
| GSE54994 | KLHL7 | 55975 | 20 | 2 | 31 | |
| GSE60625 | KLHL7 | 55975 | 0 | 0 | 11 | |
| GSE74703 | KLHL7 | 55975 | 4 | 0 | 32 | |
| GSE74704 | KLHL7 | 55975 | 11 | 1 | 8 | |
| TCGA | KLHL7 | 55975 | 56 | 4 | 36 |
Total number of gains: 148; Total number of losses: 18; Total Number of normals: 322.
Somatic mutations of KLHL7:
Generating mutation plots.
Highly correlated genes for KLHL7:
Showing top 20/1412 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KLHL7 | SMCR8 | 0.798613 | 3 | 0 | 3 |
| KLHL7 | FAM76B | 0.781585 | 3 | 0 | 3 |
| KLHL7 | SFT2D3 | 0.779642 | 3 | 0 | 3 |
| KLHL7 | CEP68 | 0.774079 | 3 | 0 | 3 |
| KLHL7 | ZHX2 | 0.757595 | 3 | 0 | 3 |
| KLHL7 | EIF2D | 0.755965 | 3 | 0 | 3 |
| KLHL7 | CCDC126 | 0.743209 | 3 | 0 | 3 |
| KLHL7 | DNMBP | 0.742885 | 3 | 0 | 3 |
| KLHL7 | EMG1 | 0.742678 | 6 | 0 | 5 |
| KLHL7 | ZNF343 | 0.737095 | 3 | 0 | 3 |
| KLHL7 | USP32 | 0.733974 | 3 | 0 | 3 |
| KLHL7 | EXOC6 | 0.733667 | 3 | 0 | 3 |
| KLHL7 | NF1 | 0.733299 | 3 | 0 | 3 |
| KLHL7 | ZNF121 | 0.730323 | 3 | 0 | 3 |
| KLHL7 | PMS2 | 0.729049 | 3 | 0 | 3 |
| KLHL7 | PCNP | 0.727864 | 3 | 0 | 3 |
| KLHL7 | UBR1 | 0.712871 | 4 | 0 | 4 |
| KLHL7 | VMA21 | 0.711746 | 4 | 0 | 3 |
| KLHL7 | DNAJC27 | 0.708248 | 3 | 0 | 3 |
| KLHL7 | SEC61A2 | 0.706068 | 4 | 0 | 4 |
For details and further investigation, click here
