| Full name: interleukin 18 receptor accessory protein | Alias Symbol: AcPL|CD218b | ||
| Type: protein-coding gene | Cytoband: 2q12.1 | ||
| Entrez ID: 8807 | HGNC ID: HGNC:5989 | Ensembl Gene: ENSG00000115607 | OMIM ID: 604509 |
| Drug and gene relationship at DGIdb | |||
IL18RAP involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05321 | Inflammatory bowel disease (IBD) |
Expression of IL18RAP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IL18RAP | 8807 | 207072_at | 0.5539 | 0.5562 | |
| GSE20347 | IL18RAP | 8807 | 207072_at | -0.0719 | 0.5456 | |
| GSE23400 | IL18RAP | 8807 | 207072_at | -0.0168 | 0.6825 | |
| GSE26886 | IL18RAP | 8807 | 207072_at | -0.1147 | 0.7923 | |
| GSE29001 | IL18RAP | 8807 | 207072_at | -0.2934 | 0.2356 | |
| GSE38129 | IL18RAP | 8807 | 207072_at | -0.2118 | 0.0639 | |
| GSE45670 | IL18RAP | 8807 | 207072_at | -0.2445 | 0.3336 | |
| GSE53622 | IL18RAP | 8807 | 81884 | -0.0656 | 0.6186 | |
| GSE53624 | IL18RAP | 8807 | 81884 | -0.4437 | 0.0001 | |
| GSE63941 | IL18RAP | 8807 | 207072_at | -0.0193 | 0.9083 | |
| GSE77861 | IL18RAP | 8807 | 207072_at | -0.1424 | 0.1176 | |
| GSE97050 | IL18RAP | 8807 | A_33_P3221960 | -0.0256 | 0.9340 | |
| SRP064894 | IL18RAP | 8807 | RNAseq | -0.4515 | 0.2106 | |
| SRP133303 | IL18RAP | 8807 | RNAseq | -0.5687 | 0.0382 | |
| SRP159526 | IL18RAP | 8807 | RNAseq | -0.8187 | 0.3252 | |
| SRP219564 | IL18RAP | 8807 | RNAseq | -0.2418 | 0.5806 | |
| TCGA | IL18RAP | 8807 | RNAseq | -0.5413 | 0.1231 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by IL18RAP expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IL18RAP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IL18RAP | 8807 | 5 | 2 | 23 | |
| GSE20123 | IL18RAP | 8807 | 5 | 2 | 23 | |
| GSE43470 | IL18RAP | 8807 | 4 | 1 | 38 | |
| GSE46452 | IL18RAP | 8807 | 1 | 4 | 54 | |
| GSE47630 | IL18RAP | 8807 | 7 | 0 | 33 | |
| GSE54993 | IL18RAP | 8807 | 0 | 6 | 64 | |
| GSE54994 | IL18RAP | 8807 | 11 | 0 | 42 | |
| GSE60625 | IL18RAP | 8807 | 0 | 3 | 8 | |
| GSE74703 | IL18RAP | 8807 | 4 | 1 | 31 | |
| GSE74704 | IL18RAP | 8807 | 3 | 1 | 16 | |
| TCGA | IL18RAP | 8807 | 35 | 5 | 56 |
Total number of gains: 75; Total number of losses: 25; Total Number of normals: 388.
Somatic mutations of IL18RAP:
Generating mutation plots.
Highly correlated genes for IL18RAP:
Showing top 20/182 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IL18RAP | NEK6 | 0.776241 | 3 | 0 | 3 |
| IL18RAP | SLC43A2 | 0.738096 | 3 | 0 | 3 |
| IL18RAP | ASPH | 0.738058 | 3 | 0 | 3 |
| IL18RAP | DHODH | 0.696584 | 3 | 0 | 3 |
| IL18RAP | AK2 | 0.670034 | 3 | 0 | 3 |
| IL18RAP | TIFAB | 0.659943 | 4 | 0 | 3 |
| IL18RAP | GPR171 | 0.658973 | 11 | 0 | 10 |
| IL18RAP | MOB3B | 0.658692 | 4 | 0 | 3 |
| IL18RAP | TMEM123 | 0.648458 | 3 | 0 | 3 |
| IL18RAP | GNGT2 | 0.641736 | 5 | 0 | 4 |
| IL18RAP | SH3KBP1 | 0.637224 | 3 | 0 | 3 |
| IL18RAP | ARHGAP9 | 0.63441 | 7 | 0 | 5 |
| IL18RAP | GIMAP5 | 0.631439 | 4 | 0 | 4 |
| IL18RAP | RGS19 | 0.631028 | 3 | 0 | 3 |
| IL18RAP | ELF2 | 0.628941 | 3 | 0 | 3 |
| IL18RAP | HAVCR2 | 0.623027 | 4 | 0 | 3 |
| IL18RAP | PILRA | 0.622031 | 5 | 0 | 3 |
| IL18RAP | CAMK4 | 0.619753 | 4 | 0 | 3 |
| IL18RAP | C16orf54 | 0.610359 | 6 | 0 | 5 |
| IL18RAP | IL2RB | 0.608499 | 10 | 0 | 8 |
For details and further investigation, click here
