TMEM123

 

Full name: transmembrane protein 123 Alias Symbol: PORIMIN|KCT3
Type: protein-coding gene Cytoband: 11q22.2
Entrez ID: 114908 HGNC ID: HGNC:30138 Ensembl Gene: ENSG00000152558 OMIM ID: 606356
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of TMEM123:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TMEM123 114908 211967_at 0.3090 0.3780
GSE20347 TMEM123 114908 211967_at 0.8787 0.0033
GSE23400 TMEM123 114908 211967_at 0.8064 0.0000
GSE26886 TMEM123 114908 211967_at 0.1311 0.7073
GSE29001 TMEM123 114908 211967_at 0.5990 0.0121
GSE38129 TMEM123 114908 211967_at 0.7071 0.0001
GSE45670 TMEM123 114908 211967_at 0.4371 0.1664
GSE53622 TMEM123 114908 87996 0.8345 0.0000
GSE53624 TMEM123 114908 87996 0.6524 0.0000
GSE63941 TMEM123 114908 211967_at -0.1062 0.8486
GSE77861 TMEM123 114908 211967_at 0.5076 0.1774
GSE97050 TMEM123 114908 A_24_P309415 0.3232 0.2152
SRP007169 TMEM123 114908 RNAseq 2.9722 0.0009
SRP008496 TMEM123 114908 RNAseq 2.1309 0.0014
SRP064894 TMEM123 114908 RNAseq 0.9583 0.0080
SRP133303 TMEM123 114908 RNAseq 0.5957 0.0098
SRP159526 TMEM123 114908 RNAseq 0.3711 0.2096
SRP193095 TMEM123 114908 RNAseq 0.4270 0.0307
SRP219564 TMEM123 114908 RNAseq 1.2204 0.0151
TCGA TMEM123 114908 RNAseq 0.0691 0.1201

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by TMEM123 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TMEM123:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TMEM123 114908 5 8 17
GSE20123 TMEM123 114908 5 8 17
GSE43470 TMEM123 114908 6 5 32
GSE46452 TMEM123 114908 5 24 30
GSE47630 TMEM123 114908 2 19 19
GSE54993 TMEM123 114908 9 2 59
GSE54994 TMEM123 114908 6 18 29
GSE60625 TMEM123 114908 0 3 8
GSE74703 TMEM123 114908 4 4 28
GSE74704 TMEM123 114908 5 4 11
TCGA TMEM123 114908 10 44 42

Total number of gains: 57; Total number of losses: 139; Total Number of normals: 292.  

 

Somatic mutations of TMEM123:

 

Generating mutation plots.

 

Highly correlated genes for TMEM123:

 

Showing top 20/782 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TMEM123CISD20.76385303
TMEM123KREMEN10.743898303
TMEM123BIRC20.73913913011
TMEM123TNFRSF210.734359303
TMEM123SMCR80.725204303
TMEM123KCNE30.711482303
TMEM123C12orf660.706526303
TMEM123IMMP1L0.705795303
TMEM123ROBO10.704952303
TMEM123CD163L10.702965303
TMEM123PHTF10.698082303
TMEM123SMARCAD10.695896303
TMEM123RALGAPA20.694622303
TMEM123CDYL0.68962303
TMEM123EP4000.680581303
TMEM123SLC40A10.678713404
TMEM123DHRS130.678662303
TMEM123NIF3L10.675457706
TMEM123TRIM440.671298303
TMEM123AMMECR1L0.671095403

For details and further investigation, click here