| Full name: interleukin 7 | Alias Symbol: IL-7 | ||
| Type: protein-coding gene | Cytoband: 8q21.13 | ||
| Entrez ID: 3574 | HGNC ID: HGNC:6023 | Ensembl Gene: ENSG00000104432 | OMIM ID: 146660 |
| Drug and gene relationship at DGIdb | |||
IL7 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04630 | Jak-STAT signaling pathway |
Expression of IL7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IL7 | 3574 | 206693_at | -0.7682 | 0.3746 | |
| GSE20347 | IL7 | 3574 | 206693_at | -0.7692 | 0.0000 | |
| GSE23400 | IL7 | 3574 | 206693_at | -0.0729 | 0.0033 | |
| GSE26886 | IL7 | 3574 | 206693_at | -1.0080 | 0.0032 | |
| GSE29001 | IL7 | 3574 | 206693_at | -0.5468 | 0.0376 | |
| GSE38129 | IL7 | 3574 | 206693_at | -0.4340 | 0.0183 | |
| GSE45670 | IL7 | 3574 | 206693_at | -0.7156 | 0.0562 | |
| GSE53622 | IL7 | 3574 | 72029 | -0.8506 | 0.0000 | |
| GSE53624 | IL7 | 3574 | 106797 | -1.1003 | 0.0000 | |
| GSE63941 | IL7 | 3574 | 206693_at | -2.3973 | 0.0398 | |
| GSE77861 | IL7 | 3574 | 206693_at | -0.3585 | 0.0314 | |
| GSE97050 | IL7 | 3574 | A_23_P8961 | 0.0628 | 0.9520 | |
| SRP064894 | IL7 | 3574 | RNAseq | -0.3622 | 0.1747 | |
| SRP133303 | IL7 | 3574 | RNAseq | -0.3463 | 0.2985 | |
| SRP159526 | IL7 | 3574 | RNAseq | -0.6909 | 0.1915 | |
| SRP193095 | IL7 | 3574 | RNAseq | -0.2004 | 0.3651 | |
| SRP219564 | IL7 | 3574 | RNAseq | -0.2713 | 0.6172 | |
| TCGA | IL7 | 3574 | RNAseq | 0.1183 | 0.6073 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by IL7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IL7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IL7 | 3574 | 16 | 2 | 12 | |
| GSE20123 | IL7 | 3574 | 18 | 2 | 10 | |
| GSE43470 | IL7 | 3574 | 18 | 1 | 24 | |
| GSE46452 | IL7 | 3574 | 21 | 0 | 38 | |
| GSE47630 | IL7 | 3574 | 23 | 0 | 17 | |
| GSE54993 | IL7 | 3574 | 0 | 19 | 51 | |
| GSE54994 | IL7 | 3574 | 30 | 0 | 23 | |
| GSE60625 | IL7 | 3574 | 0 | 4 | 7 | |
| GSE74703 | IL7 | 3574 | 15 | 1 | 20 | |
| GSE74704 | IL7 | 3574 | 12 | 1 | 7 | |
| TCGA | IL7 | 3574 | 51 | 3 | 42 |
Total number of gains: 204; Total number of losses: 33; Total Number of normals: 251.
Somatic mutations of IL7:
Generating mutation plots.
Highly correlated genes for IL7:
Showing top 20/920 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IL7 | CERS3 | 0.719646 | 3 | 0 | 3 |
| IL7 | KIAA0319L | 0.70113 | 3 | 0 | 3 |
| IL7 | VCPIP1 | 0.688073 | 3 | 0 | 3 |
| IL7 | TMEM165 | 0.66827 | 3 | 0 | 3 |
| IL7 | APH1A | 0.667716 | 4 | 0 | 3 |
| IL7 | HERPUD1 | 0.667572 | 3 | 0 | 3 |
| IL7 | GIMAP7 | 0.664653 | 6 | 0 | 5 |
| IL7 | SCP2 | 0.659654 | 9 | 0 | 7 |
| IL7 | PLA2G4A | 0.657586 | 3 | 0 | 3 |
| IL7 | TLR3 | 0.656569 | 11 | 0 | 9 |
| IL7 | PLEKHA7 | 0.655777 | 7 | 0 | 6 |
| IL7 | SLC35A5 | 0.655367 | 3 | 0 | 3 |
| IL7 | MBNL3 | 0.655346 | 7 | 0 | 6 |
| IL7 | C2CD2 | 0.654645 | 3 | 0 | 3 |
| IL7 | DCAF10 | 0.653055 | 6 | 0 | 5 |
| IL7 | PCGF3 | 0.651784 | 5 | 0 | 4 |
| IL7 | HES1 | 0.650013 | 3 | 0 | 3 |
| IL7 | FRYL | 0.648414 | 4 | 0 | 3 |
| IL7 | RBM45 | 0.647518 | 3 | 0 | 3 |
| IL7 | CCDC97 | 0.645386 | 3 | 0 | 3 |
For details and further investigation, click here
