PLA2G4A

 

Full name: phospholipase A2 group IVA Alias Symbol: cPLA2-alpha
Type: protein-coding gene Cytoband: 1q31.1
Entrez ID: 5321 HGNC ID: HGNC:9035 Ensembl Gene: ENSG00000116711 OMIM ID: 600522
Drug and gene relationship at DGIdb

 

PLA2G4A involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04014Ras signaling pathway
hsa04270Vascular smooth muscle contraction
hsa04370VEGF signaling pathway
hsa04611Platelet activation
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04724Glutamatergic synapse
hsa04726Serotonergic synapse
hsa04730Long-term depression
hsa04750Inflammatory mediator regulation of TRP channels
hsa04912GnRH signaling pathway
hsa04913Ovarian steroidogenesis
hsa04921Oxytocin signaling pathway
hsa05231Choline metabolism in cancer

 

Expression of PLA2G4A:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PLA2G4A 5321 210145_at 0.0214 0.9881
GSE20347 PLA2G4A 5321 210145_at -0.3713 0.5420
GSE23400 PLA2G4A 5321 210145_at 0.2314 0.1533
GSE26886 PLA2G4A 5321 210145_at -0.0122 0.9869
GSE29001 PLA2G4A 5321 210145_at -0.4908 0.5076
GSE38129 PLA2G4A 5321 210145_at -0.1742 0.6928
GSE45670 PLA2G4A 5321 210145_at -0.1025 0.8591
GSE53622 PLA2G4A 5321 47089 -0.3780 0.0579
GSE53624 PLA2G4A 5321 47089 -0.5584 0.0003
GSE63941 PLA2G4A 5321 210145_at -2.2406 0.1001
GSE77861 PLA2G4A 5321 210145_at -0.2929 0.8021
GSE97050 PLA2G4A 5321 A_23_P11685 0.2549 0.4062
SRP007169 PLA2G4A 5321 RNAseq 0.3105 0.7044
SRP008496 PLA2G4A 5321 RNAseq 0.0362 0.9608
SRP064894 PLA2G4A 5321 RNAseq -1.1762 0.0007
SRP133303 PLA2G4A 5321 RNAseq -0.7383 0.0469
SRP159526 PLA2G4A 5321 RNAseq -0.1114 0.8700
SRP193095 PLA2G4A 5321 RNAseq -0.4258 0.1052
SRP219564 PLA2G4A 5321 RNAseq -0.1976 0.7678
TCGA PLA2G4A 5321 RNAseq 0.2469 0.2249

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by PLA2G4A expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PLA2G4A:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PLA2G4A 5321 10 0 20
GSE20123 PLA2G4A 5321 10 0 20
GSE43470 PLA2G4A 5321 6 1 36
GSE46452 PLA2G4A 5321 3 1 55
GSE47630 PLA2G4A 5321 14 0 26
GSE54993 PLA2G4A 5321 0 6 64
GSE54994 PLA2G4A 5321 15 0 38
GSE60625 PLA2G4A 5321 0 0 11
GSE74703 PLA2G4A 5321 6 1 29
GSE74704 PLA2G4A 5321 4 0 16
TCGA PLA2G4A 5321 40 4 52

Total number of gains: 108; Total number of losses: 13; Total Number of normals: 367.  

 

Somatic mutations of PLA2G4A:

 

Generating mutation plots.

 

Highly correlated genes for PLA2G4A:

 

Showing top 20/97 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PLA2G4AACER30.817433303
PLA2G4APOLG0.782374303
PLA2G4ATK20.726642303
PLA2G4ATRAF3IP20.7099303
PLA2G4AABHD60.707327303
PLA2G4AANKS60.701008303
PLA2G4AEIF2AK40.687833404
PLA2G4AELK30.680935303
PLA2G4AEXOC6B0.68025303
PLA2G4AAKIP10.679713303
PLA2G4AKREMEN10.678868303
PLA2G4ASLC9A60.674827303
PLA2G4AFER0.671687303
PLA2G4AAPEH0.669927303
PLA2G4AGPN10.669898303
PLA2G4ACRLF30.66791403
PLA2G4APSPH0.666345303
PLA2G4AF30.657595303
PLA2G4AIL70.657586303
PLA2G4ACCDC1260.657582303

For details and further investigation, click here