| Full name: toll like receptor 3 | Alias Symbol: CD283 | ||
| Type: protein-coding gene | Cytoband: 4q35.1 | ||
| Entrez ID: 7098 | HGNC ID: HGNC:11849 | Ensembl Gene: ENSG00000164342 | OMIM ID: 603029 |
| Drug and gene relationship at DGIdb | |||
TLR3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04620 | Toll-like receptor signaling pathway | |
| hsa05160 | Hepatitis C | |
| hsa05161 | Hepatitis B | |
| hsa05164 | Influenza A | |
| hsa05168 | Herpes simplex infection |
Expression of TLR3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TLR3 | 7098 | 206271_at | -1.3814 | 0.1115 | |
| GSE20347 | TLR3 | 7098 | 206271_at | -1.9843 | 0.0000 | |
| GSE23400 | TLR3 | 7098 | 206271_at | -0.3076 | 0.0000 | |
| GSE26886 | TLR3 | 7098 | 239587_at | -1.9773 | 0.0003 | |
| GSE29001 | TLR3 | 7098 | 206271_at | -1.0385 | 0.0109 | |
| GSE38129 | TLR3 | 7098 | 206271_at | -1.6559 | 0.0000 | |
| GSE45670 | TLR3 | 7098 | 206271_at | -0.7719 | 0.0660 | |
| GSE53622 | TLR3 | 7098 | 53743 | -1.2700 | 0.0000 | |
| GSE53624 | TLR3 | 7098 | 147354 | -1.6902 | 0.0000 | |
| GSE63941 | TLR3 | 7098 | 206271_at | 0.0447 | 0.9768 | |
| GSE77861 | TLR3 | 7098 | 242667_at | -0.1224 | 0.2803 | |
| GSE97050 | TLR3 | 7098 | A_23_P29922 | -0.5023 | 0.2515 | |
| SRP007169 | TLR3 | 7098 | RNAseq | -1.2800 | 0.0839 | |
| SRP064894 | TLR3 | 7098 | RNAseq | -1.7334 | 0.0000 | |
| SRP133303 | TLR3 | 7098 | RNAseq | -0.7191 | 0.1072 | |
| SRP159526 | TLR3 | 7098 | RNAseq | -1.4826 | 0.0632 | |
| SRP193095 | TLR3 | 7098 | RNAseq | -1.4990 | 0.0000 | |
| SRP219564 | TLR3 | 7098 | RNAseq | -0.6734 | 0.2767 | |
| TCGA | TLR3 | 7098 | RNAseq | -0.2193 | 0.2053 |
Upregulated datasets: 0; Downregulated datasets: 8.
Survival by TLR3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TLR3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TLR3 | 7098 | 2 | 11 | 17 | |
| GSE20123 | TLR3 | 7098 | 2 | 11 | 17 | |
| GSE43470 | TLR3 | 7098 | 1 | 14 | 28 | |
| GSE46452 | TLR3 | 7098 | 1 | 36 | 22 | |
| GSE47630 | TLR3 | 7098 | 0 | 22 | 18 | |
| GSE54993 | TLR3 | 7098 | 10 | 0 | 60 | |
| GSE54994 | TLR3 | 7098 | 3 | 12 | 38 | |
| GSE60625 | TLR3 | 7098 | 0 | 0 | 11 | |
| GSE74703 | TLR3 | 7098 | 1 | 11 | 24 | |
| GSE74704 | TLR3 | 7098 | 1 | 5 | 14 | |
| TCGA | TLR3 | 7098 | 10 | 34 | 52 |
Total number of gains: 31; Total number of losses: 156; Total Number of normals: 301.
Somatic mutations of TLR3:
Generating mutation plots.
Highly correlated genes for TLR3:
Showing top 20/1361 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TLR3 | VCPIP1 | 0.755613 | 3 | 0 | 3 |
| TLR3 | PRPF38A | 0.723446 | 3 | 0 | 3 |
| TLR3 | MLIP | 0.722285 | 3 | 0 | 3 |
| TLR3 | FBXL3 | 0.721197 | 4 | 0 | 3 |
| TLR3 | EIF1AY | 0.717285 | 3 | 0 | 3 |
| TLR3 | NAAA | 0.717104 | 8 | 0 | 8 |
| TLR3 | SPATA18 | 0.716058 | 6 | 0 | 6 |
| TLR3 | FBXO8 | 0.713975 | 7 | 0 | 7 |
| TLR3 | NBN | 0.713056 | 3 | 0 | 3 |
| TLR3 | USP9Y | 0.711393 | 3 | 0 | 3 |
| TLR3 | CPEB3 | 0.709264 | 10 | 0 | 10 |
| TLR3 | MSRA | 0.706969 | 10 | 0 | 9 |
| TLR3 | JAK2 | 0.70416 | 10 | 0 | 9 |
| TLR3 | CALCOCO2 | 0.698358 | 12 | 0 | 10 |
| TLR3 | KAT2B | 0.696728 | 11 | 0 | 9 |
| TLR3 | EIF4E3 | 0.691182 | 7 | 0 | 7 |
| TLR3 | DLG2 | 0.690693 | 10 | 0 | 9 |
| TLR3 | CNOT6L | 0.690321 | 7 | 0 | 7 |
| TLR3 | TRIM6 | 0.689569 | 7 | 0 | 6 |
| TLR3 | HPGD | 0.687386 | 11 | 0 | 10 |
For details and further investigation, click here
