| Full name: interleukin 7 receptor | Alias Symbol: CD127|IL7RA | ||
| Type: protein-coding gene | Cytoband: 5p13.2 | ||
| Entrez ID: 3575 | HGNC ID: HGNC:6024 | Ensembl Gene: ENSG00000168685 | OMIM ID: 146661 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
IL7R involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04068 | FoxO signaling pathway | |
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04630 | Jak-STAT signaling pathway |
Expression of IL7R:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IL7R | 3575 | 205798_at | 0.7939 | 0.4847 | |
| GSE20347 | IL7R | 3575 | 205798_at | 0.1000 | 0.8010 | |
| GSE23400 | IL7R | 3575 | 205798_at | 0.2080 | 0.0125 | |
| GSE26886 | IL7R | 3575 | 226218_at | 0.9275 | 0.2634 | |
| GSE29001 | IL7R | 3575 | 205798_at | 0.5864 | 0.0425 | |
| GSE38129 | IL7R | 3575 | 205798_at | 0.1445 | 0.6624 | |
| GSE45670 | IL7R | 3575 | 226218_at | 0.5945 | 0.2842 | |
| GSE53622 | IL7R | 3575 | 127696 | 1.0087 | 0.0000 | |
| GSE53624 | IL7R | 3575 | 1099 | 0.7115 | 0.0000 | |
| GSE63941 | IL7R | 3575 | 205798_at | -0.8792 | 0.3700 | |
| GSE77861 | IL7R | 3575 | 205798_at | 0.3149 | 0.1258 | |
| GSE97050 | IL7R | 3575 | A_23_P404494 | 1.1465 | 0.1871 | |
| SRP007169 | IL7R | 3575 | RNAseq | 2.6009 | 0.0003 | |
| SRP008496 | IL7R | 3575 | RNAseq | 2.2680 | 0.0000 | |
| SRP064894 | IL7R | 3575 | RNAseq | 1.3111 | 0.0004 | |
| SRP133303 | IL7R | 3575 | RNAseq | 1.1290 | 0.0075 | |
| SRP159526 | IL7R | 3575 | RNAseq | 0.5557 | 0.5290 | |
| SRP193095 | IL7R | 3575 | RNAseq | 1.6517 | 0.0000 | |
| SRP219564 | IL7R | 3575 | RNAseq | 0.0926 | 0.9006 | |
| TCGA | IL7R | 3575 | RNAseq | 0.2466 | 0.1976 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by IL7R expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IL7R:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IL7R | 3575 | 10 | 0 | 20 | |
| GSE20123 | IL7R | 3575 | 10 | 0 | 20 | |
| GSE43470 | IL7R | 3575 | 17 | 0 | 26 | |
| GSE46452 | IL7R | 3575 | 6 | 21 | 32 | |
| GSE47630 | IL7R | 3575 | 6 | 12 | 22 | |
| GSE54993 | IL7R | 3575 | 5 | 4 | 61 | |
| GSE54994 | IL7R | 3575 | 26 | 2 | 25 | |
| GSE60625 | IL7R | 3575 | 0 | 0 | 11 | |
| GSE74703 | IL7R | 3575 | 13 | 0 | 23 | |
| GSE74704 | IL7R | 3575 | 9 | 0 | 11 | |
| TCGA | IL7R | 3575 | 52 | 6 | 38 |
Total number of gains: 154; Total number of losses: 45; Total Number of normals: 289.
Somatic mutations of IL7R:
Generating mutation plots.
Highly correlated genes for IL7R:
Showing top 20/510 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IL7R | HAVCR2 | 0.751264 | 3 | 0 | 3 |
| IL7R | WDR81 | 0.714819 | 3 | 0 | 3 |
| IL7R | PIK3AP1 | 0.714371 | 5 | 0 | 5 |
| IL7R | C3AR1 | 0.687092 | 6 | 0 | 5 |
| IL7R | SLC15A3 | 0.684849 | 4 | 0 | 4 |
| IL7R | CERKL | 0.681158 | 3 | 0 | 3 |
| IL7R | PLEK2 | 0.676268 | 6 | 0 | 5 |
| IL7R | SLC25A13 | 0.674069 | 3 | 0 | 3 |
| IL7R | UAP1L1 | 0.669674 | 3 | 0 | 3 |
| IL7R | TPCN2 | 0.666421 | 3 | 0 | 3 |
| IL7R | CHST11 | 0.663759 | 7 | 0 | 6 |
| IL7R | BIN2 | 0.661267 | 5 | 0 | 3 |
| IL7R | TIGIT | 0.657982 | 5 | 0 | 5 |
| IL7R | ALPK2 | 0.655226 | 4 | 0 | 3 |
| IL7R | RNF217 | 0.655201 | 3 | 0 | 3 |
| IL7R | C2orf69 | 0.653681 | 3 | 0 | 3 |
| IL7R | FCGR3A | 0.65255 | 3 | 0 | 3 |
| IL7R | ZNF451 | 0.652301 | 3 | 0 | 3 |
| IL7R | TOMM20 | 0.651259 | 3 | 0 | 3 |
| IL7R | CDCA7 | 0.651217 | 4 | 0 | 4 |
For details and further investigation, click here
