| Full name: alpha kinase 2 | Alias Symbol: HAK | ||
| Type: protein-coding gene | Cytoband: 18q21.31-q21.32 | ||
| Entrez ID: 115701 | HGNC ID: HGNC:20565 | Ensembl Gene: ENSG00000198796 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of ALPK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ALPK2 | 115701 | 228367_at | 0.9912 | 0.2430 | |
| GSE45670 | ALPK2 | 115701 | 228367_at | 0.8412 | 0.0076 | |
| GSE97050 | ALPK2 | 115701 | A_23_P15876 | 0.8228 | 0.1715 | |
| SRP007169 | ALPK2 | 115701 | RNAseq | 4.4442 | 0.0013 | |
| SRP064894 | ALPK2 | 115701 | RNAseq | 3.2437 | 0.0000 | |
| SRP133303 | ALPK2 | 115701 | RNAseq | 3.1833 | 0.0000 | |
| SRP159526 | ALPK2 | 115701 | RNAseq | -0.0626 | 0.9383 | |
| SRP193095 | ALPK2 | 115701 | RNAseq | 2.6232 | 0.0000 | |
| SRP219564 | ALPK2 | 115701 | RNAseq | 2.7189 | 0.0026 | |
| TCGA | ALPK2 | 115701 | RNAseq | 0.2326 | 0.3654 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by ALPK2 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of ALPK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ALPK2 | 115701 | 2 | 8 | 20 | |
| GSE20123 | ALPK2 | 115701 | 2 | 8 | 20 | |
| GSE43470 | ALPK2 | 115701 | 0 | 5 | 38 | |
| GSE46452 | ALPK2 | 115701 | 1 | 26 | 32 | |
| GSE47630 | ALPK2 | 115701 | 5 | 20 | 15 | |
| GSE54993 | ALPK2 | 115701 | 10 | 0 | 60 | |
| GSE54994 | ALPK2 | 115701 | 0 | 18 | 35 | |
| GSE60625 | ALPK2 | 115701 | 0 | 4 | 7 | |
| GSE74703 | ALPK2 | 115701 | 0 | 5 | 31 | |
| GSE74704 | ALPK2 | 115701 | 2 | 5 | 13 | |
| TCGA | ALPK2 | 115701 | 9 | 44 | 43 |
Total number of gains: 31; Total number of losses: 143; Total Number of normals: 314.
Somatic mutations of ALPK2:
Generating mutation plots.
Highly correlated genes for ALPK2:
Showing top 20/366 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ALPK2 | ADAMTS12 | 0.830125 | 3 | 0 | 3 |
| ALPK2 | MMP3 | 0.807485 | 3 | 0 | 3 |
| ALPK2 | CHST11 | 0.804387 | 3 | 0 | 3 |
| ALPK2 | TDO2 | 0.803919 | 3 | 0 | 3 |
| ALPK2 | TNC | 0.803189 | 3 | 0 | 3 |
| ALPK2 | NCF2 | 0.796546 | 3 | 0 | 3 |
| ALPK2 | XPR1 | 0.791254 | 3 | 0 | 3 |
| ALPK2 | ZNF469 | 0.789671 | 4 | 0 | 4 |
| ALPK2 | ESM1 | 0.782329 | 3 | 0 | 3 |
| ALPK2 | VOPP1 | 0.779125 | 3 | 0 | 3 |
| ALPK2 | COL5A1 | 0.771719 | 4 | 0 | 4 |
| ALPK2 | SERPINE1 | 0.759598 | 3 | 0 | 3 |
| ALPK2 | LOXL2 | 0.756523 | 3 | 0 | 3 |
| ALPK2 | CXCL5 | 0.750975 | 3 | 0 | 3 |
| ALPK2 | COL5A2 | 0.750391 | 4 | 0 | 4 |
| ALPK2 | PI15 | 0.750149 | 3 | 0 | 3 |
| ALPK2 | NEK6 | 0.743047 | 3 | 0 | 3 |
| ALPK2 | THY1 | 0.739914 | 4 | 0 | 4 |
| ALPK2 | FST | 0.738205 | 3 | 0 | 3 |
| ALPK2 | GSTO1 | 0.737373 | 3 | 0 | 3 |
For details and further investigation, click here
