RNF217

 

Full name: ring finger protein 217 Alias Symbol: MGC26996|dJ84N20.1
Type: protein-coding gene Cytoband: 6q22.31
Entrez ID: 154214 HGNC ID: HGNC:21487 Ensembl Gene: ENSG00000146373 OMIM ID: 
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of RNF217:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 RNF217 154214 226885_at 0.3384 0.2074
GSE26886 RNF217 154214 226885_at 1.1136 0.0001
GSE45670 RNF217 154214 226885_at 0.3996 0.1346
GSE53622 RNF217 154214 66079 0.6201 0.0000
GSE53624 RNF217 154214 66079 0.9750 0.0000
GSE63941 RNF217 154214 226885_at -0.6846 0.3109
GSE77861 RNF217 154214 226885_at 1.3896 0.0006
GSE97050 RNF217 154214 A_23_P353005 0.4248 0.1820
SRP007169 RNF217 154214 RNAseq 1.4242 0.0056
SRP008496 RNF217 154214 RNAseq 1.4372 0.0000
SRP064894 RNF217 154214 RNAseq 0.6154 0.0209
SRP133303 RNF217 154214 RNAseq 0.7096 0.0012
SRP159526 RNF217 154214 RNAseq 0.7865 0.0393
SRP193095 RNF217 154214 RNAseq 0.7885 0.0030
SRP219564 RNF217 154214 RNAseq 0.1590 0.5880
TCGA RNF217 154214 RNAseq 0.2841 0.0044

Upregulated datasets: 4; Downregulated datasets: 0.  

 

Survival by RNF217 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of RNF217:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 RNF217 154214 3 4 23
GSE20123 RNF217 154214 4 3 23
GSE43470 RNF217 154214 5 0 38
GSE46452 RNF217 154214 2 11 46
GSE47630 RNF217 154214 9 4 27
GSE54993 RNF217 154214 3 3 64
GSE54994 RNF217 154214 8 8 37
GSE60625 RNF217 154214 0 1 10
GSE74703 RNF217 154214 4 0 32
GSE74704 RNF217 154214 1 1 18
TCGA RNF217 154214 13 19 64

Total number of gains: 52; Total number of losses: 54; Total Number of normals: 382.  

 

Somatic mutations of RNF217:

 

Generating mutation plots.

 

Highly correlated genes for RNF217:

 

Showing top 20/1062 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
RNF217PRRC2C0.830657303
RNF217ZFHX30.807522303
RNF217C17orf750.800963303
RNF217UCP20.792235303
RNF217SMAD10.785942303
RNF217BOD10.782753303
RNF217SEC61A10.775115303
RNF217UXS10.773579404
RNF217NOL90.765201303
RNF217SEC16A0.757774404
RNF217TAP10.752639303
RNF217ZNF2600.751524303
RNF217PIGC0.749242404
RNF217PMS10.742946303
RNF217POGK0.742412303
RNF217IPO90.736799303
RNF217TUBA1B0.736498303
RNF217TRRAP0.734833404
RNF217ZNF1460.734499403
RNF217CBFA2T20.733759303

For details and further investigation, click here