| Full name: T cell immunoreceptor with Ig and ITIM domains | Alias Symbol: FLJ39873|DKFZp667A205 | ||
| Type: protein-coding gene | Cytoband: 3q13.31 | ||
| Entrez ID: 201633 | HGNC ID: HGNC:26838 | Ensembl Gene: ENSG00000181847 | OMIM ID: 612859 |
| Drug and gene relationship at DGIdb | |||
Expression of TIGIT:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TIGIT | 201633 | 240070_at | 0.7559 | 0.1414 | |
| GSE26886 | TIGIT | 201633 | 240070_at | 0.1773 | 0.1322 | |
| GSE45670 | TIGIT | 201633 | 240070_at | 0.3929 | 0.0109 | |
| GSE53622 | TIGIT | 201633 | 38619 | 0.5120 | 0.0141 | |
| GSE53624 | TIGIT | 201633 | 54336 | 0.4256 | 0.0430 | |
| GSE63941 | TIGIT | 201633 | 240070_at | 0.0613 | 0.7223 | |
| GSE77861 | TIGIT | 201633 | 240070_at | -0.0306 | 0.8805 | |
| GSE97050 | TIGIT | 201633 | A_33_P3235213 | 0.5276 | 0.1763 | |
| SRP064894 | TIGIT | 201633 | RNAseq | 0.9188 | 0.0010 | |
| SRP133303 | TIGIT | 201633 | RNAseq | 0.5242 | 0.1696 | |
| SRP159526 | TIGIT | 201633 | RNAseq | -0.1974 | 0.8492 | |
| SRP193095 | TIGIT | 201633 | RNAseq | 0.3013 | 0.2134 | |
| SRP219564 | TIGIT | 201633 | RNAseq | 1.8563 | 0.0061 | |
| TCGA | TIGIT | 201633 | RNAseq | 1.0453 | 0.0001 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by TIGIT expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TIGIT:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TIGIT | 201633 | 16 | 1 | 13 | |
| GSE20123 | TIGIT | 201633 | 17 | 1 | 12 | |
| GSE43470 | TIGIT | 201633 | 21 | 1 | 21 | |
| GSE46452 | TIGIT | 201633 | 13 | 5 | 41 | |
| GSE47630 | TIGIT | 201633 | 16 | 6 | 18 | |
| GSE54993 | TIGIT | 201633 | 2 | 6 | 62 | |
| GSE54994 | TIGIT | 201633 | 29 | 4 | 20 | |
| GSE60625 | TIGIT | 201633 | 0 | 6 | 5 | |
| GSE74703 | TIGIT | 201633 | 17 | 1 | 18 | |
| GSE74704 | TIGIT | 201633 | 13 | 1 | 6 | |
| TCGA | TIGIT | 201633 | 52 | 7 | 37 |
Total number of gains: 196; Total number of losses: 39; Total Number of normals: 253.
Somatic mutations of TIGIT:
Generating mutation plots.
Highly correlated genes for TIGIT:
Showing top 20/384 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TIGIT | IL2RG | 0.811911 | 4 | 0 | 4 |
| TIGIT | IL2RB | 0.793995 | 6 | 0 | 6 |
| TIGIT | HLA-G | 0.790548 | 3 | 0 | 3 |
| TIGIT | GZMB | 0.774562 | 6 | 0 | 6 |
| TIGIT | ACAP1 | 0.761315 | 5 | 0 | 5 |
| TIGIT | ZAP70 | 0.749532 | 6 | 0 | 6 |
| TIGIT | CD2 | 0.74866 | 5 | 0 | 5 |
| TIGIT | CXCL9 | 0.747358 | 5 | 0 | 5 |
| TIGIT | LILRB1 | 0.729148 | 5 | 0 | 4 |
| TIGIT | XPO5 | 0.728264 | 3 | 0 | 3 |
| TIGIT | SUSD3 | 0.724624 | 5 | 0 | 5 |
| TIGIT | TMEM200A | 0.724352 | 3 | 0 | 3 |
| TIGIT | POU2AF1 | 0.712039 | 3 | 0 | 3 |
| TIGIT | LAMP3 | 0.711537 | 6 | 0 | 6 |
| TIGIT | CCR8 | 0.710373 | 5 | 0 | 4 |
| TIGIT | CD3D | 0.710105 | 7 | 0 | 6 |
| TIGIT | NKG7 | 0.707109 | 6 | 0 | 5 |
| TIGIT | KCNA3 | 0.70692 | 4 | 0 | 4 |
| TIGIT | SASH3 | 0.706725 | 6 | 0 | 5 |
| TIGIT | LAIR1 | 0.705206 | 5 | 0 | 4 |
For details and further investigation, click here
