| Full name: inosine monophosphate dehydrogenase 1 | Alias Symbol: sWSS2608|LCA11 | ||
| Type: protein-coding gene | Cytoband: 7q32.1 | ||
| Entrez ID: 3614 | HGNC ID: HGNC:6052 | Ensembl Gene: ENSG00000106348 | OMIM ID: 146690 |
| Drug and gene relationship at DGIdb | |||
Expression of IMPDH1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IMPDH1 | 3614 | 204169_at | 0.7346 | 0.0322 | |
| GSE20347 | IMPDH1 | 3614 | 204169_at | 0.3726 | 0.0126 | |
| GSE23400 | IMPDH1 | 3614 | 204169_at | 0.2927 | 0.0000 | |
| GSE26886 | IMPDH1 | 3614 | 204169_at | 0.5831 | 0.0009 | |
| GSE29001 | IMPDH1 | 3614 | 204169_at | 0.2568 | 0.3955 | |
| GSE38129 | IMPDH1 | 3614 | 204169_at | 0.4504 | 0.0000 | |
| GSE45670 | IMPDH1 | 3614 | 204169_at | 0.5237 | 0.0012 | |
| GSE53622 | IMPDH1 | 3614 | 127448 | -0.2271 | 0.0000 | |
| GSE53624 | IMPDH1 | 3614 | 127448 | -0.3322 | 0.0000 | |
| GSE63941 | IMPDH1 | 3614 | 204169_at | 0.1903 | 0.5031 | |
| GSE77861 | IMPDH1 | 3614 | 204169_at | 0.6995 | 0.0132 | |
| GSE97050 | IMPDH1 | 3614 | A_24_P89701 | 0.4867 | 0.1555 | |
| SRP007169 | IMPDH1 | 3614 | RNAseq | 1.4798 | 0.0006 | |
| SRP008496 | IMPDH1 | 3614 | RNAseq | 1.4031 | 0.0000 | |
| SRP064894 | IMPDH1 | 3614 | RNAseq | 1.1656 | 0.0000 | |
| SRP133303 | IMPDH1 | 3614 | RNAseq | 0.9378 | 0.0000 | |
| SRP159526 | IMPDH1 | 3614 | RNAseq | 0.8095 | 0.0044 | |
| SRP193095 | IMPDH1 | 3614 | RNAseq | 0.8974 | 0.0000 | |
| SRP219564 | IMPDH1 | 3614 | RNAseq | 0.6121 | 0.1346 | |
| TCGA | IMPDH1 | 3614 | RNAseq | 0.0496 | 0.4693 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by IMPDH1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IMPDH1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IMPDH1 | 3614 | 8 | 1 | 21 | |
| GSE20123 | IMPDH1 | 3614 | 8 | 2 | 20 | |
| GSE43470 | IMPDH1 | 3614 | 2 | 3 | 38 | |
| GSE46452 | IMPDH1 | 3614 | 7 | 2 | 50 | |
| GSE47630 | IMPDH1 | 3614 | 7 | 4 | 29 | |
| GSE54993 | IMPDH1 | 3614 | 3 | 5 | 62 | |
| GSE54994 | IMPDH1 | 3614 | 6 | 10 | 37 | |
| GSE60625 | IMPDH1 | 3614 | 0 | 0 | 11 | |
| GSE74703 | IMPDH1 | 3614 | 2 | 3 | 31 | |
| GSE74704 | IMPDH1 | 3614 | 4 | 2 | 14 | |
| TCGA | IMPDH1 | 3614 | 28 | 22 | 46 |
Total number of gains: 75; Total number of losses: 54; Total Number of normals: 359.
Somatic mutations of IMPDH1:
Generating mutation plots.
Highly correlated genes for IMPDH1:
Showing top 20/559 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IMPDH1 | PRICKLE1 | 0.776769 | 3 | 0 | 3 |
| IMPDH1 | CDCA2 | 0.769711 | 4 | 0 | 4 |
| IMPDH1 | CTF1 | 0.761584 | 4 | 0 | 4 |
| IMPDH1 | SLC39A3 | 0.756785 | 4 | 0 | 4 |
| IMPDH1 | SPIRE1 | 0.754841 | 3 | 0 | 3 |
| IMPDH1 | PHRF1 | 0.75443 | 3 | 0 | 3 |
| IMPDH1 | KHSRP | 0.75158 | 8 | 0 | 8 |
| IMPDH1 | IWS1 | 0.751362 | 4 | 0 | 3 |
| IMPDH1 | KANSL3 | 0.744684 | 3 | 0 | 3 |
| IMPDH1 | ZNF789 | 0.743016 | 3 | 0 | 3 |
| IMPDH1 | TRAF7 | 0.741686 | 5 | 0 | 5 |
| IMPDH1 | CREB5 | 0.741338 | 3 | 0 | 3 |
| IMPDH1 | BORA | 0.740365 | 6 | 0 | 6 |
| IMPDH1 | ENG | 0.739266 | 4 | 0 | 4 |
| IMPDH1 | RPL7L1 | 0.737594 | 4 | 0 | 3 |
| IMPDH1 | ZGPAT | 0.735122 | 3 | 0 | 3 |
| IMPDH1 | ALG1 | 0.732887 | 4 | 0 | 3 |
| IMPDH1 | NACC1 | 0.731697 | 5 | 0 | 5 |
| IMPDH1 | TRAF3IP1 | 0.723249 | 3 | 0 | 3 |
| IMPDH1 | KRTCAP2 | 0.722656 | 5 | 0 | 5 |
For details and further investigation, click here
