| Full name: KAT8 regulatory NSL complex subunit 3 | Alias Symbol: FLJ10081|Rcd1|NSL3 | ||
| Type: protein-coding gene | Cytoband: 2q11.2 | ||
| Entrez ID: 55683 | HGNC ID: HGNC:25473 | Ensembl Gene: ENSG00000114982 | OMIM ID: 617742 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of KANSL3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KANSL3 | 55683 | 224318_s_at | 0.1107 | 0.7780 | |
| GSE20347 | KANSL3 | 55683 | 220950_s_at | -0.0201 | 0.8137 | |
| GSE23400 | KANSL3 | 55683 | 220950_s_at | -0.0608 | 0.1063 | |
| GSE26886 | KANSL3 | 55683 | 224318_s_at | 0.3894 | 0.1078 | |
| GSE29001 | KANSL3 | 55683 | 220950_s_at | -0.1623 | 0.2736 | |
| GSE38129 | KANSL3 | 55683 | 220950_s_at | -0.1116 | 0.1213 | |
| GSE45670 | KANSL3 | 55683 | 224318_s_at | 0.0468 | 0.7617 | |
| GSE53622 | KANSL3 | 55683 | 45476 | 0.1648 | 0.0036 | |
| GSE53624 | KANSL3 | 55683 | 45476 | 0.4488 | 0.0000 | |
| GSE63941 | KANSL3 | 55683 | 224318_s_at | -1.0779 | 0.0098 | |
| GSE77861 | KANSL3 | 55683 | 224318_s_at | 0.5538 | 0.0019 | |
| GSE97050 | KANSL3 | 55683 | A_23_P209538 | -0.2255 | 0.4685 | |
| SRP007169 | KANSL3 | 55683 | RNAseq | 1.7075 | 0.0000 | |
| SRP008496 | KANSL3 | 55683 | RNAseq | 1.4816 | 0.0000 | |
| SRP064894 | KANSL3 | 55683 | RNAseq | 0.2610 | 0.0234 | |
| SRP133303 | KANSL3 | 55683 | RNAseq | 0.2026 | 0.0143 | |
| SRP159526 | KANSL3 | 55683 | RNAseq | 0.5352 | 0.1591 | |
| SRP193095 | KANSL3 | 55683 | RNAseq | 0.3360 | 0.0000 | |
| SRP219564 | KANSL3 | 55683 | RNAseq | 0.9496 | 0.1498 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by KANSL3 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of KANSL3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KANSL3 | 55683 | 6 | 2 | 22 | |
| GSE20123 | KANSL3 | 55683 | 6 | 2 | 22 | |
| GSE43470 | KANSL3 | 55683 | 2 | 3 | 38 | |
| GSE46452 | KANSL3 | 55683 | 2 | 3 | 54 | |
| GSE47630 | KANSL3 | 55683 | 7 | 0 | 33 | |
| GSE54993 | KANSL3 | 55683 | 0 | 6 | 64 | |
| GSE54994 | KANSL3 | 55683 | 11 | 0 | 42 | |
| GSE60625 | KANSL3 | 55683 | 0 | 3 | 8 | |
| GSE74703 | KANSL3 | 55683 | 2 | 2 | 32 | |
| GSE74704 | KANSL3 | 55683 | 4 | 1 | 15 | |
| TCGA | KANSL3 | 55683 | 35 | 3 | 58 |
Total number of gains: 75; Total number of losses: 25; Total Number of normals: 388.
Somatic mutations of KANSL3:
Generating mutation plots.
Highly correlated genes for KANSL3:
Showing top 20/666 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KANSL3 | PLEKHO2 | 0.759545 | 3 | 0 | 3 |
| KANSL3 | GNPDA1 | 0.75821 | 3 | 0 | 3 |
| KANSL3 | YWHAG | 0.753779 | 3 | 0 | 3 |
| KANSL3 | CBFA2T2 | 0.751221 | 3 | 0 | 3 |
| KANSL3 | SEC16A | 0.750655 | 3 | 0 | 3 |
| KANSL3 | THAP5 | 0.74597 | 3 | 0 | 3 |
| KANSL3 | IMPDH1 | 0.744684 | 3 | 0 | 3 |
| KANSL3 | ZNF146 | 0.739149 | 3 | 0 | 3 |
| KANSL3 | TAF1 | 0.733624 | 4 | 0 | 4 |
| KANSL3 | FAN1 | 0.733535 | 3 | 0 | 3 |
| KANSL3 | CASKIN2 | 0.730987 | 3 | 0 | 3 |
| KANSL3 | KAT6B | 0.730558 | 3 | 0 | 3 |
| KANSL3 | SGIP1 | 0.727138 | 3 | 0 | 3 |
| KANSL3 | FBXO7 | 0.725359 | 4 | 0 | 4 |
| KANSL3 | S1PR1 | 0.724228 | 3 | 0 | 3 |
| KANSL3 | SRSF6 | 0.722075 | 3 | 0 | 3 |
| KANSL3 | MSI2 | 0.722069 | 4 | 0 | 4 |
| KANSL3 | RILPL2 | 0.721435 | 3 | 0 | 3 |
| KANSL3 | WTIP | 0.718707 | 3 | 0 | 3 |
| KANSL3 | CRISPLD2 | 0.718355 | 3 | 0 | 3 |
For details and further investigation, click here
