CREB5

 

Full name: cAMP responsive element binding protein 5 Alias Symbol: H_GS165L15.1|CRE-BPA
Type: protein-coding gene Cytoband: 7p15.1-p14.3
Entrez ID: 9586 HGNC ID: HGNC:16844 Ensembl Gene: ENSG00000146592 OMIM ID: 618262
Drug and gene relationship at DGIdb

 

CREB5 involved pathways:

KEGG pathway Description View
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04152AMPK signaling pathway
hsa04261Adrenergic signaling in cardiomyocytes
hsa04668TNF signaling pathway
hsa04725Cholinergic synapse
hsa04728Dopaminergic synapse
hsa04911Insulin secretion
hsa04915Estrogen signaling pathway
hsa04918Thyroid hormone synthesis
hsa04922Glucagon signaling pathway
hsa04925Aldosterone synthesis and secretion
hsa04931Insulin resistance
hsa04962Vasopressin-regulated water reabsorption
hsa05030Cocaine addiction
hsa05031Amphetamine addiction
hsa05034Alcoholism
hsa05161Hepatitis B
hsa05215Prostate cancer

 

Expression of CREB5:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CREB5 9586 232555_at -0.0884 0.9041
GSE26886 CREB5 9586 232555_at 0.5147 0.0280
GSE45670 CREB5 9586 232555_at -0.2000 0.4178
GSE53622 CREB5 9586 127362 0.5851 0.0019
GSE53624 CREB5 9586 127362 1.0848 0.0000
GSE63941 CREB5 9586 232555_at -0.2449 0.5419
GSE77861 CREB5 9586 232555_at 0.5647 0.1023
GSE97050 CREB5 9586 A_23_P157117 0.1679 0.7506
SRP007169 CREB5 9586 RNAseq 3.3981 0.0001
SRP008496 CREB5 9586 RNAseq 2.9961 0.0000
SRP064894 CREB5 9586 RNAseq -0.1993 0.5920
SRP133303 CREB5 9586 RNAseq 0.3157 0.4310
SRP159526 CREB5 9586 RNAseq 0.8189 0.1649
SRP193095 CREB5 9586 RNAseq 2.3997 0.0000
SRP219564 CREB5 9586 RNAseq -0.1350 0.8244
TCGA CREB5 9586 RNAseq -0.0085 0.9576

Upregulated datasets: 4; Downregulated datasets: 0.  

 

Survival by CREB5 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CREB5:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CREB5 9586 16 0 14
GSE20123 CREB5 9586 16 0 14
GSE43470 CREB5 9586 4 0 39
GSE46452 CREB5 9586 11 1 47
GSE47630 CREB5 9586 8 1 31
GSE54993 CREB5 9586 0 6 64
GSE54994 CREB5 9586 20 2 31
GSE60625 CREB5 9586 0 0 11
GSE74703 CREB5 9586 4 0 32
GSE74704 CREB5 9586 10 0 10
TCGA CREB5 9586 54 7 35

Total number of gains: 143; Total number of losses: 17; Total Number of normals: 328.  

 

Somatic mutations of CREB5:

 

Generating mutation plots.

 

Highly correlated genes for CREB5:

 

Showing top 20/376 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CREB5RNASEH2C0.82229303
CREB5RILP0.782654303
CREB5ZXDB0.769505303
CREB5SASS60.75241303
CREB5IMPDH10.741338303
CREB5NFKBID0.736834404
CREB5SORBS30.735039404
CREB5TM2D30.734981303
CREB5GRIN3B0.728454303
CREB5PPP1R210.728296303
CREB5POMZP30.728153303
CREB5SH3RF30.726766303
CREB5SH2B20.725546303
CREB5TMEM132A0.725217303
CREB5CTBP20.722117303
CREB5TNS40.720907303
CREB5PHYH0.720527303
CREB5ASAP20.715192303
CREB5SPRED20.711669403
CREB5FXR20.71052303

For details and further investigation, click here