| Full name: inositol polyphosphate-4-phosphatase type II B | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 4q31.21 | ||
| Entrez ID: 8821 | HGNC ID: HGNC:6075 | Ensembl Gene: ENSG00000109452 | OMIM ID: 607494 |
| Drug and gene relationship at DGIdb | |||
Expression of INPP4B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | INPP4B | 8821 | 235046_at | -0.5044 | 0.4634 | |
| GSE20347 | INPP4B | 8821 | 205376_at | -0.1258 | 0.7481 | |
| GSE23400 | INPP4B | 8821 | 205376_at | -0.0617 | 0.3480 | |
| GSE26886 | INPP4B | 8821 | 205376_at | -1.6977 | 0.0117 | |
| GSE29001 | INPP4B | 8821 | 205376_at | -0.7345 | 0.2167 | |
| GSE38129 | INPP4B | 8821 | 205376_at | -0.1918 | 0.5403 | |
| GSE45670 | INPP4B | 8821 | 205376_at | 0.2289 | 0.6636 | |
| GSE53622 | INPP4B | 8821 | 85326 | -0.7637 | 0.0000 | |
| GSE53624 | INPP4B | 8821 | 85326 | -0.4966 | 0.0000 | |
| GSE63941 | INPP4B | 8821 | 235046_at | 0.7285 | 0.5293 | |
| GSE77861 | INPP4B | 8821 | 205376_at | -0.1920 | 0.3995 | |
| GSE97050 | INPP4B | 8821 | A_33_P3283083 | -0.1632 | 0.4946 | |
| SRP007169 | INPP4B | 8821 | RNAseq | 0.1648 | 0.7713 | |
| SRP008496 | INPP4B | 8821 | RNAseq | 0.0040 | 0.9918 | |
| SRP064894 | INPP4B | 8821 | RNAseq | 0.0112 | 0.9701 | |
| SRP133303 | INPP4B | 8821 | RNAseq | -0.0249 | 0.9295 | |
| SRP159526 | INPP4B | 8821 | RNAseq | -1.2158 | 0.0125 | |
| SRP193095 | INPP4B | 8821 | RNAseq | 0.0945 | 0.7055 | |
| SRP219564 | INPP4B | 8821 | RNAseq | 0.0396 | 0.9506 | |
| TCGA | INPP4B | 8821 | RNAseq | -0.0572 | 0.7406 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by INPP4B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of INPP4B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | INPP4B | 8821 | 0 | 13 | 17 | |
| GSE20123 | INPP4B | 8821 | 0 | 13 | 17 | |
| GSE43470 | INPP4B | 8821 | 0 | 13 | 30 | |
| GSE46452 | INPP4B | 8821 | 1 | 36 | 22 | |
| GSE47630 | INPP4B | 8821 | 0 | 22 | 18 | |
| GSE54993 | INPP4B | 8821 | 10 | 0 | 60 | |
| GSE54994 | INPP4B | 8821 | 2 | 11 | 40 | |
| GSE60625 | INPP4B | 8821 | 0 | 1 | 10 | |
| GSE74703 | INPP4B | 8821 | 0 | 11 | 25 | |
| GSE74704 | INPP4B | 8821 | 0 | 7 | 13 | |
| TCGA | INPP4B | 8821 | 14 | 30 | 52 |
Total number of gains: 27; Total number of losses: 157; Total Number of normals: 304.
Somatic mutations of INPP4B:
Generating mutation plots.
Highly correlated genes for INPP4B:
Showing top 20/52 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| INPP4B | ZC3H6 | 0.71335 | 3 | 0 | 3 |
| INPP4B | PAFAH1B1 | 0.691432 | 3 | 0 | 3 |
| INPP4B | ITGB1BP2 | 0.647753 | 4 | 0 | 4 |
| INPP4B | RBPMS-AS1 | 0.64709 | 3 | 0 | 3 |
| INPP4B | NICN1 | 0.642653 | 3 | 0 | 3 |
| INPP4B | RASGRF2 | 0.641346 | 3 | 0 | 3 |
| INPP4B | SYNJ2 | 0.638779 | 3 | 0 | 3 |
| INPP4B | DEFB1 | 0.630339 | 3 | 0 | 3 |
| INPP4B | ZNF491 | 0.616972 | 3 | 0 | 3 |
| INPP4B | ZMYND10 | 0.610427 | 4 | 0 | 3 |
| INPP4B | RYR3 | 0.599786 | 3 | 0 | 3 |
| INPP4B | RASSF3 | 0.596834 | 4 | 0 | 3 |
| INPP4B | NAMPT | 0.594328 | 3 | 0 | 3 |
| INPP4B | PPP1R3C | 0.591835 | 4 | 0 | 3 |
| INPP4B | CTSV | 0.590317 | 4 | 0 | 4 |
| INPP4B | MAGIX | 0.590261 | 4 | 0 | 3 |
| INPP4B | ADAMTSL4 | 0.588163 | 6 | 0 | 5 |
| INPP4B | KLHL10 | 0.58432 | 4 | 0 | 4 |
| INPP4B | SUDS3 | 0.58345 | 3 | 0 | 3 |
| INPP4B | DNAJB8 | 0.580387 | 4 | 0 | 3 |
For details and further investigation, click here
