| Full name: ryanodine receptor 3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 15q13.3-q14 | ||
| Entrez ID: 6263 | HGNC ID: HGNC:10485 | Ensembl Gene: ENSG00000198838 | OMIM ID: 180903 |
| Drug and gene relationship at DGIdb | |||
RYR3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway | |
| hsa04713 | Circadian entrainment | |
| hsa04921 | Oxytocin signaling pathway | |
| hsa04970 | Salivary secretion |
Expression of RYR3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RYR3 | 6263 | 206306_at | -1.6790 | 0.0195 | |
| GSE20347 | RYR3 | 6263 | 206306_at | 0.4164 | 0.2212 | |
| GSE23400 | RYR3 | 6263 | 206306_at | -0.1480 | 0.0844 | |
| GSE26886 | RYR3 | 6263 | 206306_at | 0.4677 | 0.1101 | |
| GSE29001 | RYR3 | 6263 | 206306_at | 0.5628 | 0.3120 | |
| GSE38129 | RYR3 | 6263 | 206306_at | -0.3260 | 0.2899 | |
| GSE45670 | RYR3 | 6263 | 206306_at | -1.5732 | 0.0011 | |
| GSE53622 | RYR3 | 6263 | 18555 | -1.5255 | 0.0000 | |
| GSE53624 | RYR3 | 6263 | 18555 | -1.2217 | 0.0000 | |
| GSE63941 | RYR3 | 6263 | 206306_at | -0.1357 | 0.6276 | |
| GSE77861 | RYR3 | 6263 | 206306_at | 0.0698 | 0.4725 | |
| GSE97050 | RYR3 | 6263 | A_33_P3800734 | -0.4987 | 0.2223 | |
| SRP064894 | RYR3 | 6263 | RNAseq | -1.4154 | 0.0000 | |
| SRP133303 | RYR3 | 6263 | RNAseq | -0.8588 | 0.0075 | |
| SRP159526 | RYR3 | 6263 | RNAseq | -1.3154 | 0.0009 | |
| SRP193095 | RYR3 | 6263 | RNAseq | 0.9144 | 0.0019 | |
| SRP219564 | RYR3 | 6263 | RNAseq | -1.1677 | 0.0354 | |
| TCGA | RYR3 | 6263 | RNAseq | -0.8192 | 0.0063 |
Upregulated datasets: 0; Downregulated datasets: 7.
Survival by RYR3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RYR3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RYR3 | 6263 | 3 | 6 | 21 | |
| GSE20123 | RYR3 | 6263 | 3 | 6 | 21 | |
| GSE43470 | RYR3 | 6263 | 4 | 2 | 37 | |
| GSE46452 | RYR3 | 6263 | 3 | 7 | 49 | |
| GSE47630 | RYR3 | 6263 | 8 | 11 | 21 | |
| GSE54993 | RYR3 | 6263 | 4 | 6 | 60 | |
| GSE54994 | RYR3 | 6263 | 5 | 8 | 40 | |
| GSE60625 | RYR3 | 6263 | 4 | 0 | 7 | |
| GSE74703 | RYR3 | 6263 | 4 | 2 | 30 | |
| GSE74704 | RYR3 | 6263 | 2 | 5 | 13 | |
| TCGA | RYR3 | 6263 | 13 | 17 | 66 |
Total number of gains: 53; Total number of losses: 70; Total Number of normals: 365.
Somatic mutations of RYR3:
Generating mutation plots.
Highly correlated genes for RYR3:
Showing top 20/568 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RYR3 | PARD3B | 0.793934 | 3 | 0 | 3 |
| RYR3 | LRFN5 | 0.775059 | 3 | 0 | 3 |
| RYR3 | SPRYD3 | 0.750672 | 3 | 0 | 3 |
| RYR3 | KIRREL3 | 0.741828 | 3 | 0 | 3 |
| RYR3 | ALDH1A2 | 0.740413 | 3 | 0 | 3 |
| RYR3 | SLMAP | 0.738487 | 5 | 0 | 5 |
| RYR3 | PTPN21 | 0.729194 | 3 | 0 | 3 |
| RYR3 | SORCS1 | 0.725231 | 4 | 0 | 3 |
| RYR3 | ARHGAP6 | 0.714638 | 6 | 0 | 6 |
| RYR3 | LMBRD1 | 0.713488 | 5 | 0 | 5 |
| RYR3 | VMAC | 0.713183 | 3 | 0 | 3 |
| RYR3 | BTD | 0.713164 | 4 | 0 | 4 |
| RYR3 | ANO5 | 0.708843 | 4 | 0 | 3 |
| RYR3 | ADARB1 | 0.708743 | 5 | 0 | 5 |
| RYR3 | ANGPTL1 | 0.705241 | 5 | 0 | 5 |
| RYR3 | STARD9 | 0.705196 | 4 | 0 | 4 |
| RYR3 | FILIP1 | 0.70505 | 5 | 0 | 5 |
| RYR3 | STK33 | 0.704992 | 4 | 0 | 4 |
| RYR3 | PDZD4 | 0.704443 | 3 | 0 | 3 |
| RYR3 | MTURN | 0.702827 | 3 | 0 | 3 |
For details and further investigation, click here
