| Full name: defensin beta 1 | Alias Symbol: HBD-1|DEFB-1|DEFB101|HBD1|BD1|MGC51822 | ||
| Type: protein-coding gene | Cytoband: 8p23.1 | ||
| Entrez ID: 1672 | HGNC ID: HGNC:2766 | Ensembl Gene: ENSG00000164825 | OMIM ID: 602056 |
| Drug and gene relationship at DGIdb | |||
Expression of DEFB1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DEFB1 | 1672 | 210397_at | -0.3315 | 0.7075 | |
| GSE20347 | DEFB1 | 1672 | 210397_at | -1.2987 | 0.0249 | |
| GSE23400 | DEFB1 | 1672 | 210397_at | -0.7034 | 0.0104 | |
| GSE26886 | DEFB1 | 1672 | 210397_at | -0.8679 | 0.2397 | |
| GSE29001 | DEFB1 | 1672 | 210397_at | -1.6540 | 0.0690 | |
| GSE38129 | DEFB1 | 1672 | 210397_at | -0.7641 | 0.2309 | |
| GSE45670 | DEFB1 | 1672 | 210397_at | 0.6768 | 0.1400 | |
| GSE63941 | DEFB1 | 1672 | 210397_at | 1.1179 | 0.3389 | |
| GSE77861 | DEFB1 | 1672 | 210397_at | -0.0242 | 0.9711 | |
| GSE97050 | DEFB1 | 1672 | A_23_P71480 | 0.5823 | 0.5166 | |
| SRP007169 | DEFB1 | 1672 | RNAseq | -2.5677 | 0.0064 | |
| SRP064894 | DEFB1 | 1672 | RNAseq | -2.3811 | 0.0000 | |
| SRP133303 | DEFB1 | 1672 | RNAseq | -1.5482 | 0.0003 | |
| SRP159526 | DEFB1 | 1672 | RNAseq | -1.6160 | 0.0790 | |
| SRP193095 | DEFB1 | 1672 | RNAseq | -1.0574 | 0.0175 | |
| SRP219564 | DEFB1 | 1672 | RNAseq | -0.8179 | 0.5717 | |
| TCGA | DEFB1 | 1672 | RNAseq | 0.4061 | 0.1924 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by DEFB1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of DEFB1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DEFB1 | 1672 | 4 | 11 | 15 | |
| GSE20123 | DEFB1 | 1672 | 4 | 11 | 15 | |
| GSE43470 | DEFB1 | 1672 | 4 | 10 | 29 | |
| GSE46452 | DEFB1 | 1672 | 12 | 14 | 33 | |
| GSE47630 | DEFB1 | 1672 | 9 | 7 | 24 | |
| GSE54993 | DEFB1 | 1672 | 3 | 14 | 53 | |
| GSE54994 | DEFB1 | 1672 | 9 | 19 | 25 | |
| GSE60625 | DEFB1 | 1672 | 3 | 0 | 8 | |
| GSE74703 | DEFB1 | 1672 | 4 | 8 | 24 | |
| GSE74704 | DEFB1 | 1672 | 3 | 7 | 10 | |
| TCGA | DEFB1 | 1672 | 13 | 40 | 43 |
Total number of gains: 68; Total number of losses: 141; Total Number of normals: 279.
Somatic mutations of DEFB1:
Generating mutation plots.
Highly correlated genes for DEFB1:
Showing top 20/135 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DEFB1 | RHOV | 0.659547 | 5 | 0 | 4 |
| DEFB1 | BBOX1 | 0.648862 | 3 | 0 | 3 |
| DEFB1 | INPP4B | 0.630339 | 3 | 0 | 3 |
| DEFB1 | TACSTD2 | 0.612035 | 9 | 0 | 8 |
| DEFB1 | CROT | 0.604765 | 7 | 0 | 5 |
| DEFB1 | CSTA | 0.599844 | 8 | 0 | 6 |
| DEFB1 | SERPINB3 | 0.597456 | 8 | 0 | 6 |
| DEFB1 | KLK8 | 0.595311 | 8 | 0 | 6 |
| DEFB1 | IL1RN | 0.594812 | 9 | 0 | 7 |
| DEFB1 | HCAR3 | 0.592308 | 9 | 0 | 7 |
| DEFB1 | RHBDL2 | 0.583696 | 3 | 0 | 3 |
| DEFB1 | BPIFB1 | 0.583558 | 3 | 0 | 3 |
| DEFB1 | UPP1 | 0.582444 | 4 | 0 | 3 |
| DEFB1 | MAST4 | 0.58116 | 7 | 0 | 6 |
| DEFB1 | IDH1 | 0.580308 | 4 | 0 | 3 |
| DEFB1 | KRT13 | 0.572468 | 7 | 0 | 5 |
| DEFB1 | MBD2 | 0.563215 | 4 | 0 | 3 |
| DEFB1 | TMEM40 | 0.562105 | 6 | 0 | 5 |
| DEFB1 | S100A9 | 0.561309 | 9 | 0 | 4 |
| DEFB1 | SLC11A2 | 0.561101 | 6 | 0 | 5 |
For details and further investigation, click here
