| Full name: cathepsin V | Alias Symbol: CTSU | ||
| Type: protein-coding gene | Cytoband: 9q22.33 | ||
| Entrez ID: 1515 | HGNC ID: HGNC:2538 | Ensembl Gene: ENSG00000136943 | OMIM ID: 603308 |
| Drug and gene relationship at DGIdb | |||
CTSV involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04210 | Apoptosis |
Expression of CTSV:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CTSV | 1515 | 210074_at | -0.0167 | 0.9933 | |
| GSE20347 | CTSV | 1515 | 210074_at | 0.0658 | 0.8982 | |
| GSE23400 | CTSV | 1515 | 210074_at | -0.1482 | 0.5032 | |
| GSE26886 | CTSV | 1515 | 210074_at | -1.3665 | 0.0007 | |
| GSE29001 | CTSV | 1515 | 210074_at | -0.2445 | 0.7025 | |
| GSE38129 | CTSV | 1515 | 210074_at | 0.6367 | 0.1344 | |
| GSE45670 | CTSV | 1515 | 210074_at | 0.7585 | 0.0665 | |
| GSE53622 | CTSV | 1515 | 3927 | 0.7289 | 0.0026 | |
| GSE53624 | CTSV | 1515 | 3927 | 0.2978 | 0.0349 | |
| GSE63941 | CTSV | 1515 | 210074_at | 3.4145 | 0.0018 | |
| GSE77861 | CTSV | 1515 | 210074_at | 0.2184 | 0.6816 | |
| SRP007169 | CTSV | 1515 | RNAseq | 0.8265 | 0.0928 | |
| SRP008496 | CTSV | 1515 | RNAseq | 0.4523 | 0.2978 | |
| SRP064894 | CTSV | 1515 | RNAseq | -0.1749 | 0.6833 | |
| SRP133303 | CTSV | 1515 | RNAseq | 0.5852 | 0.0516 | |
| SRP159526 | CTSV | 1515 | RNAseq | 0.7547 | 0.2791 | |
| SRP193095 | CTSV | 1515 | RNAseq | -0.0259 | 0.9206 | |
| SRP219564 | CTSV | 1515 | RNAseq | -0.1098 | 0.9113 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by CTSV expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of CTSV:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CTSV | 1515 | 6 | 8 | 16 | |
| GSE20123 | CTSV | 1515 | 6 | 7 | 17 | |
| GSE43470 | CTSV | 1515 | 6 | 3 | 34 | |
| GSE46452 | CTSV | 1515 | 6 | 14 | 39 | |
| GSE47630 | CTSV | 1515 | 1 | 17 | 22 | |
| GSE54993 | CTSV | 1515 | 3 | 2 | 65 | |
| GSE54994 | CTSV | 1515 | 8 | 11 | 34 | |
| GSE60625 | CTSV | 1515 | 0 | 0 | 11 | |
| GSE74703 | CTSV | 1515 | 5 | 3 | 28 | |
| GSE74704 | CTSV | 1515 | 3 | 5 | 12 | |
| TCGA | CTSV | 1515 | 26 | 23 | 47 |
Total number of gains: 70; Total number of losses: 93; Total Number of normals: 325.
Somatic mutations of CTSV:
Generating mutation plots.
Highly correlated genes for CTSV:
Showing top 20/156 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CTSV | GJB2 | 0.678505 | 3 | 0 | 3 |
| CTSV | E2F2 | 0.669564 | 3 | 0 | 3 |
| CTSV | AP1S3 | 0.661459 | 3 | 0 | 3 |
| CTSV | LPAR5 | 0.650483 | 4 | 0 | 3 |
| CTSV | NUDT21 | 0.641034 | 3 | 0 | 3 |
| CTSV | LPCAT4 | 0.632004 | 3 | 0 | 3 |
| CTSV | EIF3J | 0.627998 | 3 | 0 | 3 |
| CTSV | MRPL35 | 0.62338 | 4 | 0 | 4 |
| CTSV | TFAP2C | 0.620153 | 3 | 0 | 3 |
| CTSV | FGFBP1 | 0.619879 | 6 | 0 | 5 |
| CTSV | SERBP1 | 0.618905 | 3 | 0 | 3 |
| CTSV | MPZL3 | 0.617062 | 4 | 0 | 3 |
| CTSV | AIF1L | 0.614383 | 3 | 0 | 3 |
| CTSV | GINS3 | 0.61216 | 4 | 0 | 4 |
| CTSV | KRT6A | 0.608131 | 7 | 0 | 6 |
| CTSV | CDCA4 | 0.604658 | 4 | 0 | 3 |
| CTSV | LGALSL | 0.604376 | 3 | 0 | 3 |
| CTSV | MARVELD2 | 0.604028 | 3 | 0 | 3 |
| CTSV | DSC3 | 0.603429 | 6 | 0 | 5 |
| CTSV | MBOAT2 | 0.602877 | 4 | 0 | 3 |
For details and further investigation, click here
