| Full name: insulin induced gene 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2q14.1-q14.2 | ||
| Entrez ID: 51141 | HGNC ID: HGNC:20452 | Ensembl Gene: ENSG00000125629 | OMIM ID: 608660 |
| Drug and gene relationship at DGIdb | |||
Expression of INSIG2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | INSIG2 | 51141 | 209566_at | 0.3392 | 0.3911 | |
| GSE20347 | INSIG2 | 51141 | 209566_at | 0.2080 | 0.3104 | |
| GSE23400 | INSIG2 | 51141 | 209566_at | 0.4207 | 0.0000 | |
| GSE26886 | INSIG2 | 51141 | 209566_at | -0.3839 | 0.1532 | |
| GSE29001 | INSIG2 | 51141 | 209566_at | 0.5875 | 0.0733 | |
| GSE38129 | INSIG2 | 51141 | 209566_at | 0.3155 | 0.0268 | |
| GSE45670 | INSIG2 | 51141 | 209566_at | 0.0371 | 0.8777 | |
| GSE53622 | INSIG2 | 51141 | 59726 | 0.4833 | 0.0000 | |
| GSE53624 | INSIG2 | 51141 | 59726 | 0.4462 | 0.0001 | |
| GSE63941 | INSIG2 | 51141 | 209566_at | -0.6031 | 0.1274 | |
| GSE77861 | INSIG2 | 51141 | 209566_at | 0.3733 | 0.3073 | |
| GSE97050 | INSIG2 | 51141 | A_33_P3321342 | 0.5902 | 0.1186 | |
| SRP007169 | INSIG2 | 51141 | RNAseq | 0.8152 | 0.0452 | |
| SRP008496 | INSIG2 | 51141 | RNAseq | 0.6253 | 0.0284 | |
| SRP064894 | INSIG2 | 51141 | RNAseq | 0.0969 | 0.6196 | |
| SRP133303 | INSIG2 | 51141 | RNAseq | 0.5759 | 0.0164 | |
| SRP159526 | INSIG2 | 51141 | RNAseq | 0.2050 | 0.5120 | |
| SRP193095 | INSIG2 | 51141 | RNAseq | 0.2756 | 0.1523 | |
| SRP219564 | INSIG2 | 51141 | RNAseq | -0.2662 | 0.4454 | |
| TCGA | INSIG2 | 51141 | RNAseq | -0.1343 | 0.0387 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by INSIG2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of INSIG2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | INSIG2 | 51141 | 4 | 1 | 25 | |
| GSE20123 | INSIG2 | 51141 | 4 | 1 | 25 | |
| GSE43470 | INSIG2 | 51141 | 3 | 1 | 39 | |
| GSE46452 | INSIG2 | 51141 | 1 | 4 | 54 | |
| GSE47630 | INSIG2 | 51141 | 6 | 0 | 34 | |
| GSE54993 | INSIG2 | 51141 | 0 | 6 | 64 | |
| GSE54994 | INSIG2 | 51141 | 11 | 0 | 42 | |
| GSE60625 | INSIG2 | 51141 | 0 | 3 | 8 | |
| GSE74703 | INSIG2 | 51141 | 3 | 1 | 32 | |
| GSE74704 | INSIG2 | 51141 | 2 | 1 | 17 | |
| TCGA | INSIG2 | 51141 | 31 | 6 | 59 |
Total number of gains: 65; Total number of losses: 24; Total Number of normals: 399.
Somatic mutations of INSIG2:
Generating mutation plots.
Highly correlated genes for INSIG2:
Showing top 20/630 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| INSIG2 | UBTD2 | 0.729297 | 4 | 0 | 4 |
| INSIG2 | RLIM | 0.728796 | 3 | 0 | 3 |
| INSIG2 | JKAMP | 0.716693 | 6 | 0 | 5 |
| INSIG2 | TACO1 | 0.714397 | 4 | 0 | 3 |
| INSIG2 | NAPG | 0.707825 | 3 | 0 | 3 |
| INSIG2 | C12orf66 | 0.705627 | 3 | 0 | 3 |
| INSIG2 | ALG14 | 0.700899 | 3 | 0 | 3 |
| INSIG2 | TRAPPC6B | 0.688862 | 3 | 0 | 3 |
| INSIG2 | GAR1 | 0.685439 | 3 | 0 | 3 |
| INSIG2 | SCYL3 | 0.684339 | 3 | 0 | 3 |
| INSIG2 | UAP1L1 | 0.683481 | 3 | 0 | 3 |
| INSIG2 | KTI12 | 0.680858 | 3 | 0 | 3 |
| INSIG2 | DSEL | 0.677153 | 3 | 0 | 3 |
| INSIG2 | PITX2 | 0.674399 | 3 | 0 | 3 |
| INSIG2 | TGFBR1 | 0.667395 | 4 | 0 | 3 |
| INSIG2 | TRMT12 | 0.666248 | 5 | 0 | 4 |
| INSIG2 | PGGT1B | 0.663138 | 3 | 0 | 3 |
| INSIG2 | MARK1 | 0.662033 | 3 | 0 | 3 |
| INSIG2 | NUDT21 | 0.656447 | 5 | 0 | 5 |
| INSIG2 | ARL6IP6 | 0.65495 | 7 | 0 | 7 |
For details and further investigation, click here
