| Full name: SCY1 like pseudokinase 3 | Alias Symbol: PACE-1|PACE1 | ||
| Type: protein-coding gene | Cytoband: 1q24.2 | ||
| Entrez ID: 57147 | HGNC ID: HGNC:19285 | Ensembl Gene: ENSG00000000457 | OMIM ID: 608192 |
| Drug and gene relationship at DGIdb | |||
Expression of SCYL3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SCYL3 | 57147 | 41329_at | -0.0434 | 0.9559 | |
| GSE20347 | SCYL3 | 57147 | 205607_s_at | -0.3055 | 0.0394 | |
| GSE23400 | SCYL3 | 57147 | 205607_s_at | -0.1118 | 0.0092 | |
| GSE26886 | SCYL3 | 57147 | 41329_at | -0.2187 | 0.5429 | |
| GSE29001 | SCYL3 | 57147 | 41329_at | -0.2859 | 0.3295 | |
| GSE38129 | SCYL3 | 57147 | 205607_s_at | -0.1364 | 0.3164 | |
| GSE45670 | SCYL3 | 57147 | 41329_at | 0.0113 | 0.9583 | |
| GSE53622 | SCYL3 | 57147 | 46916 | -0.2437 | 0.0267 | |
| GSE53624 | SCYL3 | 57147 | 107018 | -0.2186 | 0.0001 | |
| GSE63941 | SCYL3 | 57147 | 41329_at | -0.3840 | 0.3009 | |
| GSE77861 | SCYL3 | 57147 | 205607_s_at | -0.2516 | 0.2439 | |
| GSE97050 | SCYL3 | 57147 | A_23_P74320 | -0.0213 | 0.9605 | |
| SRP007169 | SCYL3 | 57147 | RNAseq | -1.0167 | 0.0094 | |
| SRP008496 | SCYL3 | 57147 | RNAseq | -0.2032 | 0.5365 | |
| SRP064894 | SCYL3 | 57147 | RNAseq | -0.4350 | 0.0296 | |
| SRP133303 | SCYL3 | 57147 | RNAseq | -0.2193 | 0.0917 | |
| SRP159526 | SCYL3 | 57147 | RNAseq | -0.0278 | 0.9324 | |
| SRP193095 | SCYL3 | 57147 | RNAseq | -0.3727 | 0.0039 | |
| SRP219564 | SCYL3 | 57147 | RNAseq | -0.2675 | 0.4443 | |
| TCGA | SCYL3 | 57147 | RNAseq | -0.0650 | 0.2542 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by SCYL3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SCYL3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SCYL3 | 57147 | 12 | 1 | 17 | |
| GSE20123 | SCYL3 | 57147 | 12 | 1 | 17 | |
| GSE43470 | SCYL3 | 57147 | 7 | 2 | 34 | |
| GSE46452 | SCYL3 | 57147 | 3 | 1 | 55 | |
| GSE47630 | SCYL3 | 57147 | 14 | 0 | 26 | |
| GSE54993 | SCYL3 | 57147 | 0 | 6 | 64 | |
| GSE54994 | SCYL3 | 57147 | 16 | 0 | 37 | |
| GSE60625 | SCYL3 | 57147 | 0 | 0 | 11 | |
| GSE74703 | SCYL3 | 57147 | 7 | 2 | 27 | |
| GSE74704 | SCYL3 | 57147 | 6 | 0 | 14 | |
| TCGA | SCYL3 | 57147 | 43 | 3 | 50 |
Total number of gains: 120; Total number of losses: 16; Total Number of normals: 352.
Somatic mutations of SCYL3:
Generating mutation plots.
Highly correlated genes for SCYL3:
Showing top 20/503 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SCYL3 | TPP2 | 0.763453 | 3 | 0 | 3 |
| SCYL3 | COMMD5 | 0.724558 | 3 | 0 | 3 |
| SCYL3 | THUMPD1 | 0.718449 | 3 | 0 | 3 |
| SCYL3 | LATS1 | 0.715467 | 3 | 0 | 3 |
| SCYL3 | ATF1 | 0.713387 | 3 | 0 | 3 |
| SCYL3 | DUSP23 | 0.70305 | 3 | 0 | 3 |
| SCYL3 | UBR3 | 0.702912 | 3 | 0 | 3 |
| SCYL3 | MIER3 | 0.702405 | 3 | 0 | 3 |
| SCYL3 | TYW1 | 0.696097 | 3 | 0 | 3 |
| SCYL3 | GPBP1 | 0.693104 | 4 | 0 | 3 |
| SCYL3 | LIPT1 | 0.688991 | 4 | 0 | 3 |
| SCYL3 | INSIG2 | 0.684339 | 3 | 0 | 3 |
| SCYL3 | FBXL3 | 0.682894 | 4 | 0 | 3 |
| SCYL3 | MMAA | 0.682328 | 5 | 0 | 5 |
| SCYL3 | APPL2 | 0.677417 | 4 | 0 | 3 |
| SCYL3 | NOL12 | 0.675243 | 3 | 0 | 3 |
| SCYL3 | VAMP7 | 0.673354 | 4 | 0 | 3 |
| SCYL3 | SNX14 | 0.672719 | 3 | 0 | 3 |
| SCYL3 | ARL6 | 0.672334 | 3 | 0 | 3 |
| SCYL3 | NSA2 | 0.6723 | 3 | 0 | 3 |
For details and further investigation, click here
