MARK1

 

Full name: microtubule affinity regulating kinase 1 Alias Symbol: MARK|PAR-1C
Type: protein-coding gene Cytoband: 1q41
Entrez ID: 4139 HGNC ID: HGNC:6896 Ensembl Gene: ENSG00000116141 OMIM ID: 606511
Drug and gene relationship at DGIdb

 

Expression of MARK1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MARK1 4139 221047_s_at 0.7623 0.1935
GSE20347 MARK1 4139 221047_s_at 0.6404 0.0005
GSE23400 MARK1 4139 221047_s_at 0.4742 0.0000
GSE26886 MARK1 4139 221047_s_at 1.8365 0.0000
GSE29001 MARK1 4139 221047_s_at 0.8614 0.0096
GSE38129 MARK1 4139 221047_s_at 0.8040 0.0000
GSE45670 MARK1 4139 221047_s_at 0.7376 0.0006
GSE53622 MARK1 4139 74745 0.2764 0.0580
GSE53624 MARK1 4139 74745 0.3444 0.0085
GSE63941 MARK1 4139 221047_s_at 2.6226 0.0048
GSE77861 MARK1 4139 221047_s_at 0.9680 0.0015
GSE97050 MARK1 4139 A_24_P179585 0.1260 0.5725
SRP007169 MARK1 4139 RNAseq 1.0721 0.0616
SRP008496 MARK1 4139 RNAseq 1.3419 0.0056
SRP064894 MARK1 4139 RNAseq 0.3820 0.0828
SRP133303 MARK1 4139 RNAseq 0.9925 0.0000
SRP159526 MARK1 4139 RNAseq 0.9485 0.0029
SRP193095 MARK1 4139 RNAseq 0.9498 0.0010
SRP219564 MARK1 4139 RNAseq 0.3714 0.2031
TCGA MARK1 4139 RNAseq 0.3211 0.0010

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by MARK1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MARK1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MARK1 4139 10 0 20
GSE20123 MARK1 4139 10 0 20
GSE43470 MARK1 4139 8 1 34
GSE46452 MARK1 4139 3 1 55
GSE47630 MARK1 4139 15 0 25
GSE54993 MARK1 4139 0 6 64
GSE54994 MARK1 4139 15 0 38
GSE60625 MARK1 4139 0 0 11
GSE74703 MARK1 4139 8 1 27
GSE74704 MARK1 4139 4 0 16
TCGA MARK1 4139 45 3 48

Total number of gains: 118; Total number of losses: 12; Total Number of normals: 358.  

 

Somatic mutations of MARK1:

 

Generating mutation plots.

 

Highly correlated genes for MARK1:

 

Showing top 20/1472 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MARK1C15orf610.830443303
MARK1RILPL20.819457303
MARK1NTPCR0.806449505
MARK1FAM89B0.800931303
MARK1MRPS260.800317303
MARK1WDR660.773571505
MARK1RPS27A0.760703303
MARK1WDR810.757589404
MARK1TMEM1380.757138505
MARK1EID20.756765303
MARK1PIGH0.753973303
MARK1RILPL10.751952303
MARK1GMCL10.745025303
MARK1MRPS310.741655303
MARK1WDR720.740972404
MARK1EIF3M0.737121303
MARK1ANKRD110.736636303
MARK1NGF0.735248303
MARK1WDR40.734231303
MARK1MSTO10.732778504

For details and further investigation, click here