| Full name: protein geranylgeranyltransferase type I subunit beta | Alias Symbol: GGTI|BGGI | ||
| Type: protein-coding gene | Cytoband: 5q22.3 | ||
| Entrez ID: 5229 | HGNC ID: HGNC:8895 | Ensembl Gene: ENSG00000164219 | OMIM ID: 602031 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PGGT1B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PGGT1B | 5229 | 235615_at | -0.5350 | 0.4030 | |
| GSE20347 | PGGT1B | 5229 | 206288_at | -0.2768 | 0.0103 | |
| GSE23400 | PGGT1B | 5229 | 206288_at | 0.0059 | 0.8920 | |
| GSE26886 | PGGT1B | 5229 | 235615_at | -0.3611 | 0.2403 | |
| GSE29001 | PGGT1B | 5229 | 206288_at | -0.1904 | 0.2498 | |
| GSE38129 | PGGT1B | 5229 | 206288_at | -0.0816 | 0.6423 | |
| GSE45670 | PGGT1B | 5229 | 235615_at | -0.1828 | 0.2150 | |
| GSE53622 | PGGT1B | 5229 | 38256 | -0.5857 | 0.0000 | |
| GSE53624 | PGGT1B | 5229 | 38256 | -0.5058 | 0.0002 | |
| GSE63941 | PGGT1B | 5229 | 235615_at | -0.0241 | 0.9728 | |
| GSE77861 | PGGT1B | 5229 | 242844_at | -0.6464 | 0.0220 | |
| GSE97050 | PGGT1B | 5229 | A_24_P605190 | 0.0055 | 0.9812 | |
| SRP007169 | PGGT1B | 5229 | RNAseq | -0.5267 | 0.1843 | |
| SRP008496 | PGGT1B | 5229 | RNAseq | -0.3191 | 0.2241 | |
| SRP064894 | PGGT1B | 5229 | RNAseq | -0.2178 | 0.0585 | |
| SRP133303 | PGGT1B | 5229 | RNAseq | 0.0050 | 0.9731 | |
| SRP159526 | PGGT1B | 5229 | RNAseq | -0.7843 | 0.0295 | |
| SRP193095 | PGGT1B | 5229 | RNAseq | -0.6919 | 0.0000 | |
| SRP219564 | PGGT1B | 5229 | RNAseq | -0.4322 | 0.1399 | |
| TCGA | PGGT1B | 5229 | RNAseq | -0.0959 | 0.1045 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PGGT1B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PGGT1B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PGGT1B | 5229 | 1 | 12 | 17 | |
| GSE20123 | PGGT1B | 5229 | 1 | 12 | 17 | |
| GSE43470 | PGGT1B | 5229 | 3 | 8 | 32 | |
| GSE46452 | PGGT1B | 5229 | 0 | 28 | 31 | |
| GSE47630 | PGGT1B | 5229 | 0 | 21 | 19 | |
| GSE54993 | PGGT1B | 5229 | 9 | 1 | 60 | |
| GSE54994 | PGGT1B | 5229 | 1 | 15 | 37 | |
| GSE60625 | PGGT1B | 5229 | 0 | 0 | 11 | |
| GSE74703 | PGGT1B | 5229 | 2 | 6 | 28 | |
| GSE74704 | PGGT1B | 5229 | 1 | 6 | 13 | |
| TCGA | PGGT1B | 5229 | 2 | 41 | 53 |
Total number of gains: 20; Total number of losses: 150; Total Number of normals: 318.
Somatic mutations of PGGT1B:
Generating mutation plots.
Highly correlated genes for PGGT1B:
Showing top 20/832 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PGGT1B | ANKHD1 | 0.775637 | 3 | 0 | 3 |
| PGGT1B | TXNDC17 | 0.752882 | 3 | 0 | 3 |
| PGGT1B | VPS54 | 0.741525 | 3 | 0 | 3 |
| PGGT1B | NUDT15 | 0.740723 | 3 | 0 | 3 |
| PGGT1B | PPP1R11 | 0.725343 | 3 | 0 | 3 |
| PGGT1B | EIF5 | 0.717722 | 3 | 0 | 3 |
| PGGT1B | TRAPPC6B | 0.713136 | 3 | 0 | 3 |
| PGGT1B | SUGT1 | 0.71237 | 5 | 0 | 5 |
| PGGT1B | SMIM15 | 0.702482 | 5 | 0 | 5 |
| PGGT1B | FAM174A | 0.701258 | 6 | 0 | 6 |
| PGGT1B | DAD1 | 0.699884 | 4 | 0 | 4 |
| PGGT1B | MBLAC2 | 0.699714 | 5 | 0 | 5 |
| PGGT1B | CHURC1 | 0.694023 | 3 | 0 | 3 |
| PGGT1B | BDH2 | 0.692556 | 3 | 0 | 3 |
| PGGT1B | UBR3 | 0.688848 | 4 | 0 | 4 |
| PGGT1B | ZBTB34 | 0.688357 | 3 | 0 | 3 |
| PGGT1B | RALA | 0.685248 | 7 | 0 | 7 |
| PGGT1B | MRPS36 | 0.685244 | 7 | 0 | 6 |
| PGGT1B | MYL12B | 0.683484 | 3 | 0 | 3 |
| PGGT1B | PPWD1 | 0.682999 | 4 | 0 | 3 |
For details and further investigation, click here
