| Full name: insulin induced gene 1 | Alias Symbol: CL-6|MGC1405 | ||
| Type: protein-coding gene | Cytoband: 7q36.3 | ||
| Entrez ID: 3638 | HGNC ID: HGNC:6083 | Ensembl Gene: ENSG00000186480 | OMIM ID: 602055 |
| Drug and gene relationship at DGIdb | |||
Expression of INSIG1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | INSIG1 | 3638 | 201626_at | -0.4895 | 0.4665 | |
| GSE20347 | INSIG1 | 3638 | 201626_at | 0.2446 | 0.4263 | |
| GSE23400 | INSIG1 | 3638 | 201627_s_at | -0.0386 | 0.7434 | |
| GSE26886 | INSIG1 | 3638 | 201626_at | -0.4139 | 0.3291 | |
| GSE29001 | INSIG1 | 3638 | 201626_at | 0.2993 | 0.5887 | |
| GSE38129 | INSIG1 | 3638 | 201626_at | 0.0762 | 0.7638 | |
| GSE45670 | INSIG1 | 3638 | 201626_at | -0.1448 | 0.7089 | |
| GSE53622 | INSIG1 | 3638 | 84935 | -0.0797 | 0.6518 | |
| GSE53624 | INSIG1 | 3638 | 84935 | 0.1526 | 0.2637 | |
| GSE63941 | INSIG1 | 3638 | 201626_at | -1.3286 | 0.0688 | |
| GSE77861 | INSIG1 | 3638 | 201626_at | 0.1456 | 0.7980 | |
| GSE97050 | INSIG1 | 3638 | A_33_P3219090 | -0.0204 | 0.9434 | |
| SRP007169 | INSIG1 | 3638 | RNAseq | 0.0872 | 0.8058 | |
| SRP008496 | INSIG1 | 3638 | RNAseq | -0.2828 | 0.4353 | |
| SRP064894 | INSIG1 | 3638 | RNAseq | -0.7675 | 0.0177 | |
| SRP133303 | INSIG1 | 3638 | RNAseq | 0.3187 | 0.3980 | |
| SRP159526 | INSIG1 | 3638 | RNAseq | -0.1486 | 0.7248 | |
| SRP193095 | INSIG1 | 3638 | RNAseq | -0.1447 | 0.4974 | |
| SRP219564 | INSIG1 | 3638 | RNAseq | -0.0462 | 0.9311 | |
| TCGA | INSIG1 | 3638 | RNAseq | -0.3605 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by INSIG1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of INSIG1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | INSIG1 | 3638 | 3 | 3 | 24 | |
| GSE20123 | INSIG1 | 3638 | 2 | 3 | 25 | |
| GSE43470 | INSIG1 | 3638 | 2 | 5 | 36 | |
| GSE46452 | INSIG1 | 3638 | 7 | 2 | 50 | |
| GSE47630 | INSIG1 | 3638 | 6 | 9 | 25 | |
| GSE54993 | INSIG1 | 3638 | 3 | 3 | 64 | |
| GSE54994 | INSIG1 | 3638 | 6 | 8 | 39 | |
| GSE60625 | INSIG1 | 3638 | 0 | 0 | 11 | |
| GSE74703 | INSIG1 | 3638 | 2 | 4 | 30 | |
| GSE74704 | INSIG1 | 3638 | 0 | 3 | 17 | |
| TCGA | INSIG1 | 3638 | 28 | 25 | 43 |
Total number of gains: 59; Total number of losses: 65; Total Number of normals: 364.
Somatic mutations of INSIG1:
Generating mutation plots.
Highly correlated genes for INSIG1:
Showing top 20/73 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| INSIG1 | BECN1 | 0.789603 | 3 | 0 | 3 |
| INSIG1 | NKAP | 0.749872 | 3 | 0 | 3 |
| INSIG1 | GTF2A2 | 0.748997 | 3 | 0 | 3 |
| INSIG1 | PDCD7 | 0.730176 | 3 | 0 | 3 |
| INSIG1 | CREBBP | 0.729834 | 3 | 0 | 3 |
| INSIG1 | UBE4A | 0.72071 | 3 | 0 | 3 |
| INSIG1 | KRAS | 0.715505 | 3 | 0 | 3 |
| INSIG1 | MTMR6 | 0.712213 | 4 | 0 | 4 |
| INSIG1 | C16orf72 | 0.711814 | 3 | 0 | 3 |
| INSIG1 | PRPF4B | 0.704674 | 3 | 0 | 3 |
| INSIG1 | NEK7 | 0.704016 | 3 | 0 | 3 |
| INSIG1 | SAR1A | 0.696319 | 3 | 0 | 3 |
| INSIG1 | UBA3 | 0.693136 | 3 | 0 | 3 |
| INSIG1 | IPO7 | 0.692439 | 3 | 0 | 3 |
| INSIG1 | ARMCX6 | 0.689664 | 3 | 0 | 3 |
| INSIG1 | KCTD21 | 0.68509 | 3 | 0 | 3 |
| INSIG1 | LATS2 | 0.679484 | 3 | 0 | 3 |
| INSIG1 | ZNF208 | 0.664755 | 3 | 0 | 3 |
| INSIG1 | ZMAT3 | 0.66419 | 3 | 0 | 3 |
| INSIG1 | RORA | 0.663175 | 3 | 0 | 3 |
For details and further investigation, click here
