| Full name: syntaxin binding protein 3 | Alias Symbol: UNC-18C | ||
| Type: protein-coding gene | Cytoband: 1p13.3 | ||
| Entrez ID: 6814 | HGNC ID: HGNC:11446 | Ensembl Gene: ENSG00000116266 | OMIM ID: 608339 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of STXBP3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | STXBP3 | 6814 | 203310_at | -0.5865 | 0.1712 | |
| GSE20347 | STXBP3 | 6814 | 203310_at | -0.5434 | 0.0000 | |
| GSE23400 | STXBP3 | 6814 | 203310_at | -0.0708 | 0.3383 | |
| GSE26886 | STXBP3 | 6814 | 203310_at | -0.7988 | 0.0016 | |
| GSE29001 | STXBP3 | 6814 | 203310_at | -0.1229 | 0.6873 | |
| GSE38129 | STXBP3 | 6814 | 203310_at | -0.4894 | 0.0000 | |
| GSE45670 | STXBP3 | 6814 | 203310_at | -0.4264 | 0.0041 | |
| GSE53622 | STXBP3 | 6814 | 51400 | -0.6977 | 0.0000 | |
| GSE53624 | STXBP3 | 6814 | 51400 | -0.4241 | 0.0000 | |
| GSE63941 | STXBP3 | 6814 | 203310_at | -0.7477 | 0.0917 | |
| GSE77861 | STXBP3 | 6814 | 203310_at | -0.6713 | 0.0341 | |
| GSE97050 | STXBP3 | 6814 | A_23_P51996 | -0.5526 | 0.0867 | |
| SRP007169 | STXBP3 | 6814 | RNAseq | 0.0257 | 0.9476 | |
| SRP008496 | STXBP3 | 6814 | RNAseq | -0.0463 | 0.8414 | |
| SRP064894 | STXBP3 | 6814 | RNAseq | -0.1295 | 0.6143 | |
| SRP133303 | STXBP3 | 6814 | RNAseq | -0.0173 | 0.8991 | |
| SRP159526 | STXBP3 | 6814 | RNAseq | -0.6996 | 0.0108 | |
| SRP193095 | STXBP3 | 6814 | RNAseq | -0.4863 | 0.0000 | |
| SRP219564 | STXBP3 | 6814 | RNAseq | -0.1562 | 0.5391 | |
| TCGA | STXBP3 | 6814 | RNAseq | -0.0211 | 0.6696 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by STXBP3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of STXBP3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | STXBP3 | 6814 | 0 | 12 | 18 | |
| GSE20123 | STXBP3 | 6814 | 0 | 11 | 19 | |
| GSE43470 | STXBP3 | 6814 | 0 | 8 | 35 | |
| GSE46452 | STXBP3 | 6814 | 2 | 1 | 56 | |
| GSE47630 | STXBP3 | 6814 | 9 | 5 | 26 | |
| GSE54993 | STXBP3 | 6814 | 0 | 1 | 69 | |
| GSE54994 | STXBP3 | 6814 | 7 | 4 | 42 | |
| GSE60625 | STXBP3 | 6814 | 0 | 0 | 11 | |
| GSE74703 | STXBP3 | 6814 | 0 | 6 | 30 | |
| GSE74704 | STXBP3 | 6814 | 0 | 7 | 13 | |
| TCGA | STXBP3 | 6814 | 8 | 26 | 62 |
Total number of gains: 26; Total number of losses: 81; Total Number of normals: 381.
Somatic mutations of STXBP3:
Generating mutation plots.
Highly correlated genes for STXBP3:
Showing top 20/1288 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| STXBP3 | PAIP2 | 0.766801 | 3 | 0 | 3 |
| STXBP3 | COPS2 | 0.759754 | 3 | 0 | 3 |
| STXBP3 | CLEC3B | 0.745385 | 3 | 0 | 3 |
| STXBP3 | ESYT2 | 0.74082 | 5 | 0 | 5 |
| STXBP3 | PRADC1 | 0.740247 | 4 | 0 | 4 |
| STXBP3 | COPG2 | 0.73908 | 3 | 0 | 3 |
| STXBP3 | UBQLN1 | 0.739005 | 3 | 0 | 3 |
| STXBP3 | GNG7 | 0.736368 | 3 | 0 | 3 |
| STXBP3 | TMEM109 | 0.730124 | 3 | 0 | 3 |
| STXBP3 | TMEM19 | 0.725944 | 5 | 0 | 5 |
| STXBP3 | ZNF70 | 0.719687 | 3 | 0 | 3 |
| STXBP3 | CTTNBP2NL | 0.712624 | 9 | 0 | 9 |
| STXBP3 | HIPK1 | 0.712615 | 11 | 0 | 10 |
| STXBP3 | GLUD2 | 0.71029 | 4 | 0 | 3 |
| STXBP3 | NR3C2 | 0.709222 | 4 | 0 | 4 |
| STXBP3 | IPO7 | 0.70893 | 3 | 0 | 3 |
| STXBP3 | SLTM | 0.701793 | 6 | 0 | 5 |
| STXBP3 | NAA35 | 0.697337 | 4 | 0 | 3 |
| STXBP3 | USP25 | 0.695654 | 9 | 0 | 8 |
| STXBP3 | TMEM167B | 0.694096 | 9 | 0 | 8 |
For details and further investigation, click here
