| Full name: keratin 6A | Alias Symbol: CK6C|K6C|CK6D|K6D | ||
| Type: protein-coding gene | Cytoband: 12q13.13 | ||
| Entrez ID: 3853 | HGNC ID: HGNC:6443 | Ensembl Gene: ENSG00000205420 | OMIM ID: 148041 |
| Drug and gene relationship at DGIdb | |||
Expression of KRT6A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KRT6A | 3853 | 209125_at | -0.2378 | 0.6964 | |
| GSE20347 | KRT6A | 3853 | 209125_at | -0.5381 | 0.0088 | |
| GSE23400 | KRT6A | 3853 | 209125_at | -0.2587 | 0.0953 | |
| GSE26886 | KRT6A | 3853 | 209125_at | -1.1723 | 0.0004 | |
| GSE29001 | KRT6A | 3853 | 209125_at | -0.8081 | 0.3572 | |
| GSE38129 | KRT6A | 3853 | 209125_at | 0.4457 | 0.5563 | |
| GSE45670 | KRT6A | 3853 | 209125_at | 0.4318 | 0.0031 | |
| GSE53622 | KRT6A | 3853 | 27325 | 0.4856 | 0.1850 | |
| GSE53624 | KRT6A | 3853 | 27325 | -0.2510 | 0.0922 | |
| GSE63941 | KRT6A | 3853 | 209125_at | 6.1053 | 0.0293 | |
| GSE77861 | KRT6A | 3853 | 209125_at | -0.0981 | 0.5224 | |
| GSE97050 | KRT6A | 3853 | A_33_P3292886 | 2.3972 | 0.1325 | |
| SRP007169 | KRT6A | 3853 | RNAseq | -2.4923 | 0.0000 | |
| SRP008496 | KRT6A | 3853 | RNAseq | -2.4512 | 0.0000 | |
| SRP064894 | KRT6A | 3853 | RNAseq | -0.7964 | 0.1293 | |
| SRP133303 | KRT6A | 3853 | RNAseq | -0.2853 | 0.4347 | |
| SRP159526 | KRT6A | 3853 | RNAseq | -1.4606 | 0.1344 | |
| SRP219564 | KRT6A | 3853 | RNAseq | -0.7913 | 0.5734 | |
| TCGA | KRT6A | 3853 | RNAseq | 1.1036 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 3.
Survival by KRT6A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KRT6A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KRT6A | 3853 | 8 | 1 | 21 | |
| GSE20123 | KRT6A | 3853 | 8 | 1 | 21 | |
| GSE43470 | KRT6A | 3853 | 3 | 0 | 40 | |
| GSE46452 | KRT6A | 3853 | 7 | 1 | 51 | |
| GSE47630 | KRT6A | 3853 | 10 | 2 | 28 | |
| GSE54993 | KRT6A | 3853 | 0 | 5 | 65 | |
| GSE54994 | KRT6A | 3853 | 5 | 1 | 47 | |
| GSE60625 | KRT6A | 3853 | 0 | 0 | 11 | |
| GSE74703 | KRT6A | 3853 | 3 | 0 | 33 | |
| GSE74704 | KRT6A | 3853 | 5 | 1 | 14 | |
| TCGA | KRT6A | 3853 | 13 | 11 | 72 |
Total number of gains: 62; Total number of losses: 23; Total Number of normals: 403.
Somatic mutations of KRT6A:
Generating mutation plots.
Highly correlated genes for KRT6A:
Showing top 20/430 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KRT6A | KRT6B | 0.848354 | 13 | 0 | 13 |
| KRT6A | KRT6C | 0.819276 | 4 | 0 | 4 |
| KRT6A | SPRR1B | 0.732139 | 13 | 0 | 11 |
| KRT6A | S100A2 | 0.731357 | 12 | 0 | 11 |
| KRT6A | KRT17 | 0.725599 | 4 | 0 | 4 |
| KRT6A | KRT5 | 0.72533 | 12 | 0 | 10 |
| KRT6A | SERPINB5 | 0.723293 | 12 | 0 | 12 |
| KRT6A | DSG3 | 0.718233 | 13 | 0 | 12 |
| KRT6A | SFN | 0.717912 | 12 | 0 | 11 |
| KRT6A | CLCA2 | 0.711357 | 12 | 0 | 10 |
| KRT6A | FAM83C | 0.706206 | 6 | 0 | 4 |
| KRT6A | GJB2 | 0.697913 | 7 | 0 | 5 |
| KRT6A | TUBA4A | 0.692265 | 10 | 0 | 9 |
| KRT6A | KRT16 | 0.691976 | 13 | 0 | 12 |
| KRT6A | GJB6 | 0.69043 | 9 | 0 | 8 |
| KRT6A | FERMT1 | 0.687158 | 5 | 0 | 4 |
| KRT6A | ANXA2 | 0.686189 | 10 | 0 | 10 |
| KRT6A | KRT14 | 0.679899 | 11 | 0 | 9 |
| KRT6A | DUSP11 | 0.677937 | 6 | 0 | 5 |
| KRT6A | FAM83H | 0.672449 | 4 | 0 | 3 |
For details and further investigation, click here
