| Full name: keratin 6B | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12q13.13 | ||
| Entrez ID: 3854 | HGNC ID: HGNC:6444 | Ensembl Gene: ENSG00000185479 | OMIM ID: 148042 |
| Drug and gene relationship at DGIdb | |||
Expression of KRT6B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KRT6B | 3854 | 209126_x_at | -0.3915 | 0.7398 | |
| GSE20347 | KRT6B | 3854 | 213680_at | -1.0167 | 0.0066 | |
| GSE23400 | KRT6B | 3854 | 209126_x_at | -0.4934 | 0.0039 | |
| GSE26886 | KRT6B | 3854 | 213680_at | -2.9595 | 0.0098 | |
| GSE29001 | KRT6B | 3854 | 213680_at | -0.8219 | 0.3152 | |
| GSE38129 | KRT6B | 3854 | 213680_at | 0.1982 | 0.8169 | |
| GSE45670 | KRT6B | 3854 | 213680_at | 0.3600 | 0.0294 | |
| GSE53622 | KRT6B | 3854 | 61049 | -0.3038 | 0.4041 | |
| GSE53624 | KRT6B | 3854 | 61049 | -0.8918 | 0.0000 | |
| GSE63941 | KRT6B | 3854 | 209126_x_at | 3.5397 | 0.0115 | |
| GSE77861 | KRT6B | 3854 | 213680_at | 0.0557 | 0.9075 | |
| GSE97050 | KRT6B | 3854 | A_23_P76249 | 1.1532 | 0.1925 | |
| SRP007169 | KRT6B | 3854 | RNAseq | -3.0109 | 0.0000 | |
| SRP008496 | KRT6B | 3854 | RNAseq | -2.4566 | 0.0000 | |
| SRP064894 | KRT6B | 3854 | RNAseq | 0.2102 | 0.7194 | |
| SRP133303 | KRT6B | 3854 | RNAseq | -0.5505 | 0.3188 | |
| SRP159526 | KRT6B | 3854 | RNAseq | -1.5502 | 0.0344 | |
| SRP219564 | KRT6B | 3854 | RNAseq | -0.3811 | 0.7857 | |
| TCGA | KRT6B | 3854 | RNAseq | 1.2736 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 5.
Survival by KRT6B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KRT6B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KRT6B | 3854 | 8 | 1 | 21 | |
| GSE20123 | KRT6B | 3854 | 8 | 1 | 21 | |
| GSE43470 | KRT6B | 3854 | 3 | 0 | 40 | |
| GSE46452 | KRT6B | 3854 | 7 | 1 | 51 | |
| GSE47630 | KRT6B | 3854 | 10 | 2 | 28 | |
| GSE54993 | KRT6B | 3854 | 0 | 5 | 65 | |
| GSE54994 | KRT6B | 3854 | 5 | 1 | 47 | |
| GSE60625 | KRT6B | 3854 | 0 | 0 | 11 | |
| GSE74703 | KRT6B | 3854 | 3 | 0 | 33 | |
| GSE74704 | KRT6B | 3854 | 5 | 1 | 14 | |
| TCGA | KRT6B | 3854 | 13 | 11 | 72 |
Total number of gains: 62; Total number of losses: 23; Total Number of normals: 403.
Somatic mutations of KRT6B:
Generating mutation plots.
Highly correlated genes for KRT6B:
Showing top 20/449 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KRT6B | KRT6A | 0.848354 | 13 | 0 | 13 |
| KRT6B | KRT6C | 0.826471 | 4 | 0 | 4 |
| KRT6B | GJB6 | 0.752568 | 9 | 0 | 9 |
| KRT6B | SPRR1B | 0.747458 | 13 | 0 | 12 |
| KRT6B | GJB2 | 0.746284 | 7 | 0 | 6 |
| KRT6B | KRT5 | 0.745566 | 9 | 0 | 9 |
| KRT6B | SPRR2A | 0.743952 | 4 | 0 | 4 |
| KRT6B | SPRR2D | 0.738034 | 4 | 0 | 4 |
| KRT6B | SERPINB5 | 0.729438 | 13 | 0 | 13 |
| KRT6B | DSG3 | 0.728323 | 12 | 0 | 12 |
| KRT6B | SPRR2E | 0.718141 | 4 | 0 | 4 |
| KRT6B | SPRR2F | 0.717205 | 4 | 0 | 4 |
| KRT6B | GPX2 | 0.716412 | 3 | 0 | 3 |
| KRT6B | DSC2 | 0.699245 | 12 | 0 | 11 |
| KRT6B | CLCA2 | 0.69838 | 12 | 0 | 10 |
| KRT6B | KRT16 | 0.697045 | 13 | 0 | 12 |
| KRT6B | S100A2 | 0.692979 | 12 | 0 | 10 |
| KRT6B | SFN | 0.690831 | 12 | 0 | 12 |
| KRT6B | SBSN | 0.688673 | 8 | 0 | 7 |
| KRT6B | PGLYRP3 | 0.681395 | 4 | 0 | 3 |
For details and further investigation, click here
