TTLL12

 

Full name: tubulin tyrosine ligase like 12 Alias Symbol: KIAA0153
Type: protein-coding gene Cytoband: 22q13.2
Entrez ID: 23170 HGNC ID: HGNC:28974 Ensembl Gene: ENSG00000100304 OMIM ID: 
Drug and gene relationship at DGIdb

 

Expression of TTLL12:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TTLL12 23170 1552257_a_at -0.1065 0.8939
GSE20347 TTLL12 23170 216251_s_at -0.5423 0.0058
GSE23400 TTLL12 23170 216251_s_at -0.3671 0.0000
GSE26886 TTLL12 23170 1552257_a_at -0.6388 0.0012
GSE29001 TTLL12 23170 216251_s_at -0.7674 0.0011
GSE38129 TTLL12 23170 216251_s_at -0.1709 0.5340
GSE45670 TTLL12 23170 1552257_a_at -0.0776 0.7609
GSE53622 TTLL12 23170 69169 -0.3621 0.0012
GSE53624 TTLL12 23170 69169 -0.5118 0.0000
GSE63941 TTLL12 23170 1552257_a_at 0.8594 0.0270
GSE77861 TTLL12 23170 1552257_a_at -0.2979 0.3872
GSE97050 TTLL12 23170 A_23_P143748 -0.1849 0.5426
SRP007169 TTLL12 23170 RNAseq -1.2727 0.0008
SRP008496 TTLL12 23170 RNAseq -1.5676 0.0000
SRP064894 TTLL12 23170 RNAseq -0.6802 0.0035
SRP133303 TTLL12 23170 RNAseq -0.8879 0.0000
SRP159526 TTLL12 23170 RNAseq -0.5661 0.0880
SRP193095 TTLL12 23170 RNAseq -0.7000 0.0000
SRP219564 TTLL12 23170 RNAseq -0.4012 0.5405
TCGA TTLL12 23170 RNAseq 0.1836 0.0097

Upregulated datasets: 0; Downregulated datasets: 2.  

 

Survival by TTLL12 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TTLL12:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TTLL12 23170 6 6 18
GSE20123 TTLL12 23170 6 5 19
GSE43470 TTLL12 23170 3 6 34
GSE46452 TTLL12 23170 31 2 26
GSE47630 TTLL12 23170 9 4 27
GSE54993 TTLL12 23170 3 6 61
GSE54994 TTLL12 23170 11 8 34
GSE60625 TTLL12 23170 5 0 6
GSE74703 TTLL12 23170 3 4 29
GSE74704 TTLL12 23170 3 3 14
TCGA TTLL12 23170 26 15 55

Total number of gains: 106; Total number of losses: 59; Total Number of normals: 323.  

 

Somatic mutations of TTLL12:

 

Generating mutation plots.

 

Highly correlated genes for TTLL12:

 

Showing top 20/718 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TTLL12ANKRD220.700074303
TTLL12EFHB0.689418303
TTLL12ERP440.684271404
TTLL12SNX330.678392303
TTLL12GANC0.672906303
TTLL12IPPK0.655627606
TTLL12TRERF10.651008303
TTLL12ANXA20.648493706
TTLL12ZNRF10.647779504
TTLL12UBE2F0.642363303
TTLL12GNA150.638753806
TTLL12CCNYL10.637184403
TTLL12TPD52L10.636608908
TTLL12STAP20.634928806
TTLL12DESI10.6306911007
TTLL12PKP30.629773909
TTLL12RIPK30.627958303
TTLL12AMMECR10.627098704
TTLL12ZNF7700.626136504
TTLL12TMEM400.624931807

For details and further investigation, click here