| Full name: interferon regulatory factor 5 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 7q32.1 | ||
| Entrez ID: 3663 | HGNC ID: HGNC:6120 | Ensembl Gene: ENSG00000128604 | OMIM ID: 607218 |
| Drug and gene relationship at DGIdb | |||
IRF5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04620 | Toll-like receptor signaling pathway |
Expression of IRF5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IRF5 | 3663 | 205469_s_at | -0.1398 | 0.6852 | |
| GSE20347 | IRF5 | 3663 | 205469_s_at | -0.0542 | 0.6757 | |
| GSE23400 | IRF5 | 3663 | 205469_s_at | -0.1208 | 0.0228 | |
| GSE26886 | IRF5 | 3663 | 205469_s_at | 0.2174 | 0.2452 | |
| GSE29001 | IRF5 | 3663 | 205469_s_at | -0.0572 | 0.8327 | |
| GSE38129 | IRF5 | 3663 | 205469_s_at | -0.0960 | 0.4297 | |
| GSE45670 | IRF5 | 3663 | 239412_at | 0.1519 | 0.7468 | |
| GSE53622 | IRF5 | 3663 | 96924 | 0.0079 | 0.9719 | |
| GSE53624 | IRF5 | 3663 | 96924 | -0.1858 | 0.2325 | |
| GSE63941 | IRF5 | 3663 | 205469_s_at | 0.6513 | 0.0914 | |
| GSE77861 | IRF5 | 3663 | 205469_s_at | -0.0663 | 0.5639 | |
| GSE97050 | IRF5 | 3663 | A_23_P500271 | 0.4628 | 0.3069 | |
| SRP007169 | IRF5 | 3663 | RNAseq | -0.6891 | 0.1758 | |
| SRP008496 | IRF5 | 3663 | RNAseq | -0.6728 | 0.0331 | |
| SRP064894 | IRF5 | 3663 | RNAseq | -0.0289 | 0.8522 | |
| SRP133303 | IRF5 | 3663 | RNAseq | -0.1514 | 0.4686 | |
| SRP159526 | IRF5 | 3663 | RNAseq | -0.6322 | 0.2988 | |
| SRP193095 | IRF5 | 3663 | RNAseq | -0.3334 | 0.0511 | |
| SRP219564 | IRF5 | 3663 | RNAseq | -0.3345 | 0.5623 | |
| TCGA | IRF5 | 3663 | RNAseq | 0.4062 | 0.0008 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by IRF5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IRF5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IRF5 | 3663 | 8 | 1 | 21 | |
| GSE20123 | IRF5 | 3663 | 8 | 1 | 21 | |
| GSE43470 | IRF5 | 3663 | 2 | 3 | 38 | |
| GSE46452 | IRF5 | 3663 | 7 | 2 | 50 | |
| GSE47630 | IRF5 | 3663 | 7 | 4 | 29 | |
| GSE54993 | IRF5 | 3663 | 3 | 5 | 62 | |
| GSE54994 | IRF5 | 3663 | 8 | 7 | 38 | |
| GSE60625 | IRF5 | 3663 | 0 | 0 | 11 | |
| GSE74703 | IRF5 | 3663 | 2 | 3 | 31 | |
| GSE74704 | IRF5 | 3663 | 4 | 1 | 15 | |
| TCGA | IRF5 | 3663 | 29 | 21 | 46 |
Total number of gains: 78; Total number of losses: 48; Total Number of normals: 362.
Somatic mutations of IRF5:
Generating mutation plots.
Highly correlated genes for IRF5:
Showing top 20/83 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IRF5 | LYPD5 | 0.705402 | 4 | 0 | 4 |
| IRF5 | MLKL | 0.688653 | 3 | 0 | 3 |
| IRF5 | TNFAIP8L2 | 0.676749 | 3 | 0 | 3 |
| IRF5 | UBE2G1 | 0.673683 | 3 | 0 | 3 |
| IRF5 | SUSD3 | 0.670105 | 3 | 0 | 3 |
| IRF5 | RAB4B | 0.667276 | 3 | 0 | 3 |
| IRF5 | SFSWAP | 0.666938 | 3 | 0 | 3 |
| IRF5 | PSENEN | 0.659802 | 3 | 0 | 3 |
| IRF5 | RNF113A | 0.653344 | 3 | 0 | 3 |
| IRF5 | FAM110A | 0.65207 | 3 | 0 | 3 |
| IRF5 | NCKAP1L | 0.648766 | 3 | 0 | 3 |
| IRF5 | SERPINB11 | 0.644782 | 3 | 0 | 3 |
| IRF5 | VSNL1 | 0.637715 | 4 | 0 | 3 |
| IRF5 | RAB35 | 0.627762 | 4 | 0 | 3 |
| IRF5 | GNG5 | 0.627612 | 4 | 0 | 3 |
| IRF5 | DMWD | 0.62398 | 3 | 0 | 3 |
| IRF5 | STX11 | 0.623088 | 4 | 0 | 3 |
| IRF5 | PLD2 | 0.618317 | 6 | 0 | 5 |
| IRF5 | OGFOD1 | 0.61142 | 4 | 0 | 3 |
| IRF5 | CNOT10 | 0.608755 | 4 | 0 | 3 |
For details and further investigation, click here
