IRF6

 

Full name: interferon regulatory factor 6 Alias Symbol: OFC6|VWS1
Type: protein-coding gene Cytoband: 1q32.2
Entrez ID: 3664 HGNC ID: HGNC:6121 Ensembl Gene: ENSG00000117595 OMIM ID: 607199
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of IRF6:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 IRF6 3664 202597_at 0.3688 0.1369
GSE20347 IRF6 3664 202597_at 0.2300 0.1562
GSE23400 IRF6 3664 202597_at 0.3419 0.0033
GSE26886 IRF6 3664 202597_at -0.1176 0.5112
GSE29001 IRF6 3664 202597_at 0.1973 0.2540
GSE38129 IRF6 3664 202597_at 0.9711 0.0056
GSE45670 IRF6 3664 202597_at 0.5912 0.0010
GSE53622 IRF6 3664 12311 0.8274 0.0002
GSE53624 IRF6 3664 12311 0.5206 0.0000
GSE63941 IRF6 3664 202597_at 3.7118 0.0003
GSE77861 IRF6 3664 202597_at 0.6547 0.0248
GSE97050 IRF6 3664 A_23_P748 2.0250 0.2372
SRP007169 IRF6 3664 RNAseq -0.5649 0.2100
SRP008496 IRF6 3664 RNAseq -0.4296 0.2707
SRP064894 IRF6 3664 RNAseq -0.0538 0.8893
SRP133303 IRF6 3664 RNAseq 0.4022 0.0623
SRP159526 IRF6 3664 RNAseq 0.4668 0.4413
SRP193095 IRF6 3664 RNAseq 0.2889 0.1918
SRP219564 IRF6 3664 RNAseq 0.7803 0.4570
TCGA IRF6 3664 RNAseq 0.4485 0.0001

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by IRF6 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of IRF6:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 IRF6 3664 11 0 19
GSE20123 IRF6 3664 10 0 20
GSE43470 IRF6 3664 7 0 36
GSE46452 IRF6 3664 3 1 55
GSE47630 IRF6 3664 15 0 25
GSE54993 IRF6 3664 0 6 64
GSE54994 IRF6 3664 14 0 39
GSE60625 IRF6 3664 0 0 11
GSE74703 IRF6 3664 7 0 29
GSE74704 IRF6 3664 4 0 16
TCGA IRF6 3664 44 3 49

Total number of gains: 115; Total number of losses: 10; Total Number of normals: 363.  

 

Somatic mutations of IRF6:

 

Generating mutation plots.

 

Highly correlated genes for IRF6:

 

Showing top 20/739 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
IRF6STPG10.776495303
IRF6CDH10.750865606
IRF6TP630.74395909
IRF6CDCA7L0.738076303
IRF6MED300.717657303
IRF6FXYD30.716972807
IRF6SOGA10.711735303
IRF6LAMB30.71136312012
IRF6TIGD10.708808303
IRF6MARVELD20.708207403
IRF6FAM83B0.708126707
IRF6MKI670.706926707
IRF6SMC40.697403606
IRF6IRX20.692771504
IRF6CYB561A30.691271303
IRF6F11R0.6864391008
IRF6PSMC3IP0.686339303
IRF6HOXB70.684449504
IRF6CDC450.683573707
IRF6CDCA50.682196505

For details and further investigation, click here