HOXB7

 

Full name: homeobox B7 Alias Symbol: 
Type: protein-coding gene Cytoband: 17q21.32
Entrez ID: 3217 HGNC ID: HGNC:5118 Ensembl Gene: ENSG00000260027 OMIM ID: 142962
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of HOXB7:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 HOXB7 3217 204779_s_at 2.4546 0.0444
GSE20347 HOXB7 3217 216973_s_at 2.3119 0.0000
GSE23400 HOXB7 3217 204779_s_at 1.0064 0.0000
GSE26886 HOXB7 3217 216973_s_at 2.3796 0.0000
GSE29001 HOXB7 3217 216973_s_at 2.3877 0.0000
GSE38129 HOXB7 3217 216973_s_at 2.6309 0.0000
GSE45670 HOXB7 3217 204779_s_at 2.8178 0.0000
GSE53622 HOXB7 3217 7080 1.5694 0.0000
GSE53624 HOXB7 3217 7080 1.7854 0.0000
GSE63941 HOXB7 3217 204779_s_at 4.6000 0.0000
GSE77861 HOXB7 3217 216973_s_at 1.2213 0.0020
GSE97050 HOXB7 3217 A_23_P55281 0.6028 0.2014
SRP007169 HOXB7 3217 RNAseq 2.4043 0.0056
SRP008496 HOXB7 3217 RNAseq 2.5780 0.0000
SRP064894 HOXB7 3217 RNAseq 3.6896 0.0000
SRP133303 HOXB7 3217 RNAseq 2.5347 0.0000
SRP159526 HOXB7 3217 RNAseq 4.5394 0.0000
SRP219564 HOXB7 3217 RNAseq 2.7119 0.0000
TCGA HOXB7 3217 RNAseq 1.8776 0.0000

Upregulated datasets: 18; Downregulated datasets: 0.  

 

Survival by HOXB7 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of HOXB7:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 HOXB7 3217 5 2 23
GSE20123 HOXB7 3217 5 2 23
GSE43470 HOXB7 3217 3 1 39
GSE46452 HOXB7 3217 32 0 27
GSE47630 HOXB7 3217 9 0 31
GSE54993 HOXB7 3217 2 4 64
GSE54994 HOXB7 3217 10 6 37
GSE60625 HOXB7 3217 4 0 7
GSE74703 HOXB7 3217 3 1 32
GSE74704 HOXB7 3217 4 1 15
TCGA HOXB7 3217 27 6 63

Total number of gains: 104; Total number of losses: 23; Total Number of normals: 361.  

 

Somatic mutations of HOXB7:

 

Generating mutation plots.

 

Highly correlated genes for HOXB7:

 

Showing top 20/1906 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
HOXB7CKS1B0.77700512012
HOXB7RFC40.76442113012
HOXB7UBE2T0.763983808
HOXB7TPX20.756212012
HOXB7BLM0.75074112012
HOXB7CEP550.74974111010
HOXB7MYBL20.74941912012
HOXB7RPL39L0.74939712012
HOXB7KIF140.74911412012
HOXB7PLAU0.74685211011
HOXB7PLXNA10.74509911011
HOXB7IPO90.743668909
HOXB7TIMELESS0.74267212012
HOXB7NCAPH0.741874909
HOXB7E2F60.74044811011
HOXB7KIF4A0.74019611010
HOXB7ACTL6A0.73883113012
HOXB7SPAG50.73860112012
HOXB7SPP10.7385810010
HOXB7FOXM10.73805912012

For details and further investigation, click here