| Full name: cell division cycle 45 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 22q11.21 | ||
| Entrez ID: 8318 | HGNC ID: HGNC:1739 | Ensembl Gene: ENSG00000093009 | OMIM ID: 603465 |
| Drug and gene relationship at DGIdb | |||
CDC45 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04110 | Cell cycle |
Expression of CDC45:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CDC45 | 8318 | 204126_s_at | 1.1559 | 0.0585 | |
| GSE20347 | CDC45 | 8318 | 204126_s_at | 1.0557 | 0.0000 | |
| GSE23400 | CDC45 | 8318 | 204126_s_at | 0.6317 | 0.0000 | |
| GSE26886 | CDC45 | 8318 | 204126_s_at | 0.7751 | 0.0028 | |
| GSE29001 | CDC45 | 8318 | 204126_s_at | 0.9227 | 0.0034 | |
| GSE38129 | CDC45 | 8318 | 204126_s_at | 1.3810 | 0.0000 | |
| GSE45670 | CDC45 | 8318 | 204126_s_at | 1.0469 | 0.0000 | |
| GSE53622 | CDC45 | 8318 | 138247 | 2.0036 | 0.0000 | |
| GSE53624 | CDC45 | 8318 | 138247 | 2.1740 | 0.0000 | |
| GSE63941 | CDC45 | 8318 | 204126_s_at | 3.1443 | 0.0000 | |
| GSE77861 | CDC45 | 8318 | 204126_s_at | 1.1644 | 0.0018 | |
| GSE97050 | CDC45 | 8318 | A_23_P57379 | 0.8541 | 0.1891 | |
| SRP007169 | CDC45 | 8318 | RNAseq | 2.3219 | 0.0000 | |
| SRP008496 | CDC45 | 8318 | RNAseq | 2.2156 | 0.0000 | |
| SRP064894 | CDC45 | 8318 | RNAseq | 2.1671 | 0.0000 | |
| SRP133303 | CDC45 | 8318 | RNAseq | 1.8823 | 0.0000 | |
| SRP159526 | CDC45 | 8318 | RNAseq | 2.2298 | 0.0000 | |
| SRP193095 | CDC45 | 8318 | RNAseq | 1.4104 | 0.0000 | |
| SRP219564 | CDC45 | 8318 | RNAseq | 2.4094 | 0.0022 | |
| TCGA | CDC45 | 8318 | RNAseq | 1.7360 | 0.0000 |
Upregulated datasets: 15; Downregulated datasets: 0.
Survival by CDC45 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CDC45:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CDC45 | 8318 | 4 | 7 | 19 | |
| GSE20123 | CDC45 | 8318 | 4 | 7 | 19 | |
| GSE43470 | CDC45 | 8318 | 4 | 6 | 33 | |
| GSE46452 | CDC45 | 8318 | 33 | 1 | 25 | |
| GSE47630 | CDC45 | 8318 | 8 | 5 | 27 | |
| GSE54993 | CDC45 | 8318 | 3 | 7 | 60 | |
| GSE54994 | CDC45 | 8318 | 12 | 7 | 34 | |
| GSE60625 | CDC45 | 8318 | 5 | 0 | 6 | |
| GSE74703 | CDC45 | 8318 | 4 | 4 | 28 | |
| GSE74704 | CDC45 | 8318 | 2 | 4 | 14 | |
| TCGA | CDC45 | 8318 | 27 | 17 | 52 |
Total number of gains: 106; Total number of losses: 65; Total Number of normals: 317.
Somatic mutations of CDC45:
Generating mutation plots.
Highly correlated genes for CDC45:
Showing top 20/1860 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CDC45 | CDCA5 | 0.864059 | 7 | 0 | 7 |
| CDC45 | AURKB | 0.854291 | 12 | 0 | 12 |
| CDC45 | UBE2T | 0.854116 | 8 | 0 | 8 |
| CDC45 | UHRF1 | 0.849751 | 8 | 0 | 8 |
| CDC45 | KIF4A | 0.849367 | 11 | 0 | 11 |
| CDC45 | TPX2 | 0.835441 | 12 | 0 | 12 |
| CDC45 | MCM2 | 0.832385 | 12 | 0 | 12 |
| CDC45 | NCAPH | 0.83028 | 9 | 0 | 9 |
| CDC45 | FOXM1 | 0.830248 | 12 | 0 | 12 |
| CDC45 | RAD51 | 0.828332 | 11 | 0 | 11 |
| CDC45 | MCM5 | 0.827895 | 11 | 0 | 11 |
| CDC45 | CENPM | 0.827014 | 12 | 0 | 12 |
| CDC45 | TRIP13 | 0.824824 | 12 | 0 | 12 |
| CDC45 | KIF2C | 0.823219 | 12 | 0 | 12 |
| CDC45 | RANBP1 | 0.821754 | 12 | 0 | 11 |
| CDC45 | CEP55 | 0.821731 | 12 | 0 | 12 |
| CDC45 | UBE2C | 0.821029 | 12 | 0 | 12 |
| CDC45 | KIF14 | 0.820228 | 12 | 0 | 12 |
| CDC45 | MYBL2 | 0.819637 | 12 | 0 | 12 |
| CDC45 | RAD51AP1 | 0.817603 | 12 | 0 | 12 |
For details and further investigation, click here
