| Full name: iroquois homeobox 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 5p15.33 | ||
| Entrez ID: 153572 | HGNC ID: HGNC:14359 | Ensembl Gene: ENSG00000170561 | OMIM ID: 606198 |
| Drug and gene relationship at DGIdb | |||
Expression of IRX2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IRX2 | 153572 | 228462_at | 0.7575 | 0.3851 | |
| GSE26886 | IRX2 | 153572 | 228462_at | 1.1356 | 0.0002 | |
| GSE45670 | IRX2 | 153572 | 228462_at | 0.8915 | 0.0038 | |
| GSE53622 | IRX2 | 153572 | 72110 | 1.1791 | 0.0000 | |
| GSE53624 | IRX2 | 153572 | 72110 | 0.8270 | 0.0000 | |
| GSE63941 | IRX2 | 153572 | 228462_at | 4.3229 | 0.0001 | |
| GSE77861 | IRX2 | 153572 | 228462_at | 0.7738 | 0.0134 | |
| GSE97050 | IRX2 | 153572 | A_33_P3297562 | 1.5228 | 0.2153 | |
| SRP007169 | IRX2 | 153572 | RNAseq | 0.1356 | 0.8417 | |
| SRP064894 | IRX2 | 153572 | RNAseq | -0.5788 | 0.2345 | |
| SRP133303 | IRX2 | 153572 | RNAseq | 1.1252 | 0.0160 | |
| SRP159526 | IRX2 | 153572 | RNAseq | 1.3507 | 0.0004 | |
| TCGA | IRX2 | 153572 | RNAseq | 0.1176 | 0.5115 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by IRX2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IRX2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IRX2 | 153572 | 12 | 1 | 17 | |
| GSE20123 | IRX2 | 153572 | 12 | 1 | 17 | |
| GSE43470 | IRX2 | 153572 | 16 | 1 | 26 | |
| GSE46452 | IRX2 | 153572 | 6 | 22 | 31 | |
| GSE47630 | IRX2 | 153572 | 6 | 11 | 23 | |
| GSE54993 | IRX2 | 153572 | 5 | 5 | 60 | |
| GSE54994 | IRX2 | 153572 | 29 | 1 | 23 | |
| GSE60625 | IRX2 | 153572 | 0 | 0 | 11 | |
| GSE74703 | IRX2 | 153572 | 13 | 0 | 23 | |
| GSE74704 | IRX2 | 153572 | 11 | 0 | 9 | |
| TCGA | IRX2 | 153572 | 56 | 4 | 36 |
Total number of gains: 166; Total number of losses: 46; Total Number of normals: 276.
Somatic mutations of IRX2:
Generating mutation plots.
Highly correlated genes for IRX2:
Showing top 20/780 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IRX2 | CMTM4 | 0.832882 | 3 | 0 | 3 |
| IRX2 | APBA3 | 0.743701 | 4 | 0 | 4 |
| IRX2 | SFN | 0.741378 | 3 | 0 | 3 |
| IRX2 | S100A2 | 0.733081 | 3 | 0 | 3 |
| IRX2 | SNAPC1 | 0.730481 | 3 | 0 | 3 |
| IRX2 | PPP3CA | 0.718601 | 3 | 0 | 3 |
| IRX2 | ZNF593 | 0.711777 | 4 | 0 | 4 |
| IRX2 | HOMER1 | 0.702744 | 4 | 0 | 4 |
| IRX2 | MTERF3 | 0.69591 | 4 | 0 | 4 |
| IRX2 | IPO9 | 0.695257 | 5 | 0 | 5 |
| IRX2 | GOLIM4 | 0.694891 | 3 | 0 | 3 |
| IRX2 | IRF6 | 0.692771 | 5 | 0 | 4 |
| IRX2 | WDR43 | 0.690851 | 4 | 0 | 4 |
| IRX2 | POMZP3 | 0.687548 | 3 | 0 | 3 |
| IRX2 | DSG2 | 0.683945 | 7 | 0 | 6 |
| IRX2 | SNAPC2 | 0.683727 | 3 | 0 | 3 |
| IRX2 | SUPT16H | 0.682129 | 4 | 0 | 4 |
| IRX2 | BMS1 | 0.68176 | 4 | 0 | 4 |
| IRX2 | PLCG2 | 0.681009 | 3 | 0 | 3 |
| IRX2 | ERH | 0.680886 | 4 | 0 | 4 |
For details and further investigation, click here
