MKI67

 

Full name: marker of proliferation Ki-67 Alias Symbol: MIB-1|PPP1R105
Type: protein-coding gene Cytoband: 10q26.2
Entrez ID: 4288 HGNC ID: HGNC:7107 Ensembl Gene: ENSG00000148773 OMIM ID: 176741
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of MKI67:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MKI67 4288 212022_s_at 1.3217 0.1127
GSE20347 MKI67 4288 212020_s_at 0.8794 0.0000
GSE23400 MKI67 4288 212020_s_at 0.7873 0.0000
GSE26886 MKI67 4288 212021_s_at 0.0995 0.7955
GSE29001 MKI67 4288 212021_s_at 1.0784 0.0005
GSE38129 MKI67 4288 212020_s_at 1.2347 0.0000
GSE45670 MKI67 4288 212022_s_at 1.3310 0.0000
GSE53622 MKI67 4288 38184 1.6971 0.0000
GSE53624 MKI67 4288 38184 1.6044 0.0000
GSE63941 MKI67 4288 212022_s_at 2.8815 0.0005
GSE77861 MKI67 4288 212022_s_at 0.4017 0.1562
GSE97050 MKI67 4288 A_33_P3374210 2.8903 0.1137
SRP007169 MKI67 4288 RNAseq 3.0263 0.0000
SRP008496 MKI67 4288 RNAseq 2.3417 0.0000
SRP064894 MKI67 4288 RNAseq 1.0168 0.0015
SRP133303 MKI67 4288 RNAseq 1.3824 0.0000
SRP159526 MKI67 4288 RNAseq 0.7457 0.0179
SRP193095 MKI67 4288 RNAseq 0.9268 0.0000
SRP219564 MKI67 4288 RNAseq 1.0347 0.1877
TCGA MKI67 4288 RNAseq 0.8030 0.0000

Upregulated datasets: 10; Downregulated datasets: 0.  

 

Survival by MKI67 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MKI67:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MKI67 4288 2 7 21
GSE20123 MKI67 4288 2 7 21
GSE43470 MKI67 4288 0 10 33
GSE46452 MKI67 4288 0 11 48
GSE47630 MKI67 4288 4 13 23
GSE54993 MKI67 4288 8 1 61
GSE54994 MKI67 4288 1 9 43
GSE60625 MKI67 4288 0 0 11
GSE74703 MKI67 4288 0 6 30
GSE74704 MKI67 4288 2 3 15
TCGA MKI67 4288 7 27 62

Total number of gains: 26; Total number of losses: 94; Total Number of normals: 368.  

 

Somatic mutations of MKI67:

 

Generating mutation plots.

 

Highly correlated genes for MKI67:

 

Showing top 20/1551 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MKI67CDK10.83920712012
MKI67CEP550.83399113012
MKI67KIF2C0.83030312012
MKI67STIL0.82917512012
MKI67NUSAP10.82317212012
MKI67ASPM0.82109112012
MKI67KIF110.8180413013
MKI67ESCO20.813586606
MKI67CENPF0.81330412012
MKI67TPX20.81007413012
MKI67BUB10.80825110010
MKI67CCNA20.80771812012
MKI67BUB1B0.806691009
MKI67DLGAP50.80575113012
MKI67NUF20.79804808
MKI67KIF20A0.79671513012
MKI67CENPN0.79630612012
MKI67HJURP0.79437612012
MKI67TTK0.79423812012
MKI67FOXM10.79092413012

For details and further investigation, click here