| Full name: structural maintenance of chromosomes 4 | Alias Symbol: hCAP-C|CAP-C | ||
| Type: protein-coding gene | Cytoband: 3q25.33 | ||
| Entrez ID: 10051 | HGNC ID: HGNC:14013 | Ensembl Gene: ENSG00000113810 | OMIM ID: 605575 |
| Drug and gene relationship at DGIdb | |||
Expression of SMC4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SMC4 | 10051 | 201664_at | 0.7476 | 0.2665 | |
| GSE20347 | SMC4 | 10051 | 201664_at | 0.4070 | 0.0249 | |
| GSE23400 | SMC4 | 10051 | 201664_at | 0.5095 | 0.0008 | |
| GSE26886 | SMC4 | 10051 | 201664_at | -0.4985 | 0.0538 | |
| GSE29001 | SMC4 | 10051 | 201664_at | 0.3640 | 0.3188 | |
| GSE38129 | SMC4 | 10051 | 201664_at | 0.6612 | 0.0040 | |
| GSE45670 | SMC4 | 10051 | 201664_at | 0.1707 | 0.3813 | |
| GSE53622 | SMC4 | 10051 | 13657 | 0.5374 | 0.0000 | |
| GSE53624 | SMC4 | 10051 | 13657 | 0.5091 | 0.0000 | |
| GSE63941 | SMC4 | 10051 | 201664_at | 1.7041 | 0.0057 | |
| GSE77861 | SMC4 | 10051 | 201664_at | -0.1840 | 0.5538 | |
| GSE97050 | SMC4 | 10051 | A_33_P3248519 | 0.3613 | 0.5473 | |
| SRP007169 | SMC4 | 10051 | RNAseq | 0.2154 | 0.6820 | |
| SRP008496 | SMC4 | 10051 | RNAseq | 0.1043 | 0.7302 | |
| SRP064894 | SMC4 | 10051 | RNAseq | -0.0805 | 0.7694 | |
| SRP133303 | SMC4 | 10051 | RNAseq | 0.6777 | 0.0034 | |
| SRP159526 | SMC4 | 10051 | RNAseq | 0.9313 | 0.0000 | |
| SRP193095 | SMC4 | 10051 | RNAseq | 0.0444 | 0.8094 | |
| SRP219564 | SMC4 | 10051 | RNAseq | -0.1326 | 0.8577 | |
| TCGA | SMC4 | 10051 | RNAseq | 0.4164 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by SMC4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SMC4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SMC4 | 10051 | 22 | 0 | 8 | |
| GSE20123 | SMC4 | 10051 | 22 | 0 | 8 | |
| GSE43470 | SMC4 | 10051 | 23 | 0 | 20 | |
| GSE46452 | SMC4 | 10051 | 18 | 2 | 39 | |
| GSE47630 | SMC4 | 10051 | 19 | 3 | 18 | |
| GSE54993 | SMC4 | 10051 | 1 | 11 | 58 | |
| GSE54994 | SMC4 | 10051 | 38 | 1 | 14 | |
| GSE60625 | SMC4 | 10051 | 0 | 6 | 5 | |
| GSE74703 | SMC4 | 10051 | 20 | 0 | 16 | |
| GSE74704 | SMC4 | 10051 | 14 | 0 | 6 | |
| TCGA | SMC4 | 10051 | 77 | 0 | 19 |
Total number of gains: 254; Total number of losses: 23; Total Number of normals: 211.
Somatic mutations of SMC4:
Generating mutation plots.
Highly correlated genes for SMC4:
Showing top 20/451 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SMC4 | FAM83B | 0.738764 | 4 | 0 | 4 |
| SMC4 | NCEH1 | 0.721837 | 3 | 0 | 3 |
| SMC4 | MIR205HG | 0.721736 | 3 | 0 | 3 |
| SMC4 | RCC2 | 0.720996 | 4 | 0 | 4 |
| SMC4 | SLC25A39 | 0.720036 | 4 | 0 | 4 |
| SMC4 | IRF6 | 0.697403 | 6 | 0 | 6 |
| SMC4 | CDCA2 | 0.687727 | 3 | 0 | 3 |
| SMC4 | CMIP | 0.680403 | 3 | 0 | 3 |
| SMC4 | KDF1 | 0.67519 | 3 | 0 | 3 |
| SMC4 | SPINT2 | 0.668343 | 6 | 0 | 6 |
| SMC4 | AP1S3 | 0.66297 | 4 | 0 | 3 |
| SMC4 | KIAA1522 | 0.662267 | 4 | 0 | 3 |
| SMC4 | MKI67 | 0.659924 | 9 | 0 | 7 |
| SMC4 | F11R | 0.657222 | 7 | 0 | 6 |
| SMC4 | POM121 | 0.65672 | 4 | 0 | 4 |
| SMC4 | ASPM | 0.655322 | 11 | 0 | 9 |
| SMC4 | NUF2 | 0.652139 | 7 | 0 | 6 |
| SMC4 | FANCD2 | 0.651906 | 6 | 0 | 4 |
| SMC4 | CDK1 | 0.647988 | 9 | 0 | 7 |
| SMC4 | GEN1 | 0.645259 | 5 | 0 | 4 |
For details and further investigation, click here
