| Full name: HtrA serine peptidase 1 | Alias Symbol: HtrA|IGFBP5-protease|ARMD7 | ||
| Type: protein-coding gene | Cytoband: 10q26.13 | ||
| Entrez ID: 5654 | HGNC ID: HGNC:9476 | Ensembl Gene: ENSG00000166033 | OMIM ID: 602194 |
| Drug and gene relationship at DGIdb | |||
Expression of HTRA1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HTRA1 | 5654 | 201185_at | 0.5250 | 0.5091 | |
| GSE20347 | HTRA1 | 5654 | 201185_at | 1.4925 | 0.0001 | |
| GSE23400 | HTRA1 | 5654 | 201185_at | 0.8790 | 0.0000 | |
| GSE26886 | HTRA1 | 5654 | 201185_at | 2.5475 | 0.0000 | |
| GSE29001 | HTRA1 | 5654 | 201185_at | 1.3408 | 0.0015 | |
| GSE38129 | HTRA1 | 5654 | 201185_at | 1.0990 | 0.0046 | |
| GSE45670 | HTRA1 | 5654 | 201185_at | -0.1296 | 0.8151 | |
| GSE53622 | HTRA1 | 5654 | 145176 | 1.2079 | 0.0000 | |
| GSE53624 | HTRA1 | 5654 | 145176 | 1.6113 | 0.0000 | |
| GSE63941 | HTRA1 | 5654 | 201185_at | -4.7568 | 0.0014 | |
| GSE77861 | HTRA1 | 5654 | 201185_at | 1.2682 | 0.0124 | |
| GSE97050 | HTRA1 | 5654 | A_23_P97990 | 0.5687 | 0.4316 | |
| SRP007169 | HTRA1 | 5654 | RNAseq | 3.2899 | 0.0000 | |
| SRP008496 | HTRA1 | 5654 | RNAseq | 3.8402 | 0.0000 | |
| SRP064894 | HTRA1 | 5654 | RNAseq | 1.6752 | 0.0000 | |
| SRP133303 | HTRA1 | 5654 | RNAseq | 1.7934 | 0.0000 | |
| SRP159526 | HTRA1 | 5654 | RNAseq | 0.9042 | 0.0029 | |
| SRP193095 | HTRA1 | 5654 | RNAseq | 2.1649 | 0.0000 | |
| TCGA | HTRA1 | 5654 | RNAseq | 0.1631 | 0.0701 |
Upregulated datasets: 12; Downregulated datasets: 1.
Survival by HTRA1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HTRA1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HTRA1 | 5654 | 1 | 6 | 23 | |
| GSE20123 | HTRA1 | 5654 | 1 | 6 | 23 | |
| GSE43470 | HTRA1 | 5654 | 0 | 9 | 34 | |
| GSE46452 | HTRA1 | 5654 | 0 | 11 | 48 | |
| GSE47630 | HTRA1 | 5654 | 2 | 14 | 24 | |
| GSE54993 | HTRA1 | 5654 | 8 | 1 | 61 | |
| GSE54994 | HTRA1 | 5654 | 1 | 9 | 43 | |
| GSE60625 | HTRA1 | 5654 | 0 | 0 | 11 | |
| GSE74703 | HTRA1 | 5654 | 0 | 6 | 30 | |
| GSE74704 | HTRA1 | 5654 | 1 | 2 | 17 | |
| TCGA | HTRA1 | 5654 | 4 | 28 | 64 |
Total number of gains: 18; Total number of losses: 92; Total Number of normals: 378.
Somatic mutations of HTRA1:
Generating mutation plots.
Highly correlated genes for HTRA1:
Showing top 20/1115 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HTRA1 | COL5A2 | 0.824635 | 13 | 0 | 13 |
| HTRA1 | SPARC | 0.823078 | 13 | 0 | 13 |
| HTRA1 | LGALS1 | 0.819269 | 12 | 0 | 12 |
| HTRA1 | COL5A1 | 0.814931 | 13 | 0 | 13 |
| HTRA1 | COL12A1 | 0.814179 | 9 | 0 | 9 |
| HTRA1 | COL6A3 | 0.806812 | 13 | 0 | 13 |
| HTRA1 | COL6A1 | 0.793083 | 13 | 0 | 13 |
| HTRA1 | COL6A2 | 0.792103 | 12 | 0 | 12 |
| HTRA1 | VCAN | 0.790779 | 13 | 0 | 13 |
| HTRA1 | ISLR | 0.786645 | 12 | 0 | 12 |
| HTRA1 | CTSK | 0.780096 | 13 | 0 | 13 |
| HTRA1 | LUM | 0.771013 | 13 | 0 | 13 |
| HTRA1 | COL1A2 | 0.767648 | 13 | 0 | 13 |
| HTRA1 | MMP2 | 0.766573 | 12 | 0 | 11 |
| HTRA1 | AEBP1 | 0.765938 | 13 | 0 | 13 |
| HTRA1 | COL3A1 | 0.756731 | 13 | 0 | 12 |
| HTRA1 | CDH11 | 0.753551 | 13 | 0 | 13 |
| HTRA1 | PCOLCE | 0.753499 | 13 | 0 | 13 |
| HTRA1 | POSTN | 0.748221 | 13 | 0 | 12 |
| HTRA1 | GALNT10 | 0.746767 | 11 | 0 | 11 |
For details and further investigation, click here
