| Full name: delta like non-canonical Notch ligand 2 | Alias Symbol: MGC2487 | ||
| Type: protein-coding gene | Cytoband: 6p21.1 | ||
| Entrez ID: 65989 | HGNC ID: HGNC:21113 | Ensembl Gene: ENSG00000171462 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of DLK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DLK2 | 65989 | 220262_s_at | 0.0917 | 0.8516 | |
| GSE20347 | DLK2 | 65989 | 220262_s_at | -0.1897 | 0.1934 | |
| GSE23400 | DLK2 | 65989 | 220262_s_at | 0.1106 | 0.1037 | |
| GSE26886 | DLK2 | 65989 | 220262_s_at | 0.4355 | 0.0487 | |
| GSE29001 | DLK2 | 65989 | 220262_s_at | -0.1381 | 0.4731 | |
| GSE38129 | DLK2 | 65989 | 220262_s_at | -0.0475 | 0.7800 | |
| GSE45670 | DLK2 | 65989 | 220262_s_at | 0.2128 | 0.2940 | |
| GSE53622 | DLK2 | 65989 | 120387 | 0.3464 | 0.0001 | |
| GSE53624 | DLK2 | 65989 | 120387 | 0.2040 | 0.0083 | |
| GSE63941 | DLK2 | 65989 | 220262_s_at | 2.4527 | 0.0037 | |
| GSE77861 | DLK2 | 65989 | 220262_s_at | -0.4222 | 0.0047 | |
| GSE97050 | DLK2 | 65989 | A_33_P3254460 | 0.2761 | 0.3475 | |
| SRP007169 | DLK2 | 65989 | RNAseq | 0.1610 | 0.8327 | |
| SRP064894 | DLK2 | 65989 | RNAseq | -0.0487 | 0.8985 | |
| SRP133303 | DLK2 | 65989 | RNAseq | -0.0437 | 0.8434 | |
| SRP159526 | DLK2 | 65989 | RNAseq | -0.1891 | 0.6037 | |
| SRP193095 | DLK2 | 65989 | RNAseq | -0.0726 | 0.7750 | |
| SRP219564 | DLK2 | 65989 | RNAseq | 0.2317 | 0.7537 | |
| TCGA | DLK2 | 65989 | RNAseq | 1.3013 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by DLK2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DLK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DLK2 | 65989 | 7 | 0 | 23 | |
| GSE20123 | DLK2 | 65989 | 7 | 0 | 23 | |
| GSE43470 | DLK2 | 65989 | 6 | 0 | 37 | |
| GSE46452 | DLK2 | 65989 | 2 | 9 | 48 | |
| GSE47630 | DLK2 | 65989 | 8 | 4 | 28 | |
| GSE54993 | DLK2 | 65989 | 3 | 2 | 65 | |
| GSE54994 | DLK2 | 65989 | 11 | 4 | 38 | |
| GSE60625 | DLK2 | 65989 | 0 | 1 | 10 | |
| GSE74703 | DLK2 | 65989 | 6 | 0 | 30 | |
| GSE74704 | DLK2 | 65989 | 3 | 0 | 17 | |
| TCGA | DLK2 | 65989 | 20 | 12 | 64 |
Total number of gains: 73; Total number of losses: 32; Total Number of normals: 383.
Somatic mutations of DLK2:
Generating mutation plots.
Highly correlated genes for DLK2:
Showing top 20/232 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DLK2 | MUC17 | 0.736644 | 3 | 0 | 3 |
| DLK2 | C14orf180 | 0.727488 | 3 | 0 | 3 |
| DLK2 | SLC6A19 | 0.717371 | 3 | 0 | 3 |
| DLK2 | ITIH3 | 0.712223 | 3 | 0 | 3 |
| DLK2 | KCNT1 | 0.708447 | 3 | 0 | 3 |
| DLK2 | DGAT2 | 0.703647 | 3 | 0 | 3 |
| DLK2 | TFAP2C | 0.698435 | 3 | 0 | 3 |
| DLK2 | ANKFN1 | 0.691453 | 3 | 0 | 3 |
| DLK2 | CARD6 | 0.691256 | 3 | 0 | 3 |
| DLK2 | PPP1R3F | 0.686745 | 3 | 0 | 3 |
| DLK2 | KRT9 | 0.679979 | 3 | 0 | 3 |
| DLK2 | TTC39A | 0.67767 | 3 | 0 | 3 |
| DLK2 | MYO5B | 0.677433 | 3 | 0 | 3 |
| DLK2 | ONECUT3 | 0.675789 | 3 | 0 | 3 |
| DLK2 | GALK1 | 0.672146 | 4 | 0 | 3 |
| DLK2 | POM121L12 | 0.665359 | 3 | 0 | 3 |
| DLK2 | RIPK4 | 0.661276 | 5 | 0 | 4 |
| DLK2 | MAL2 | 0.657625 | 3 | 0 | 3 |
| DLK2 | S100A9 | 0.648828 | 3 | 0 | 3 |
| DLK2 | AGER | 0.64469 | 4 | 0 | 4 |
For details and further investigation, click here
