| Full name: lamin B receptor | Alias Symbol: DHCR14B|TDRD18 | ||
| Type: protein-coding gene | Cytoband: 1q42.12 | ||
| Entrez ID: 3930 | HGNC ID: HGNC:6518 | Ensembl Gene: ENSG00000143815 | OMIM ID: 600024 |
| Drug and gene relationship at DGIdb | |||
Expression of LBR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LBR | 3930 | 201795_at | 0.2158 | 0.6156 | |
| GSE20347 | LBR | 3930 | 201795_at | 0.5314 | 0.0025 | |
| GSE23400 | LBR | 3930 | 201795_at | 0.3088 | 0.0012 | |
| GSE26886 | LBR | 3930 | 201795_at | 0.0479 | 0.8406 | |
| GSE29001 | LBR | 3930 | 201795_at | 0.4669 | 0.0213 | |
| GSE38129 | LBR | 3930 | 201795_at | 0.4482 | 0.0030 | |
| GSE45670 | LBR | 3930 | 201795_at | -0.0917 | 0.7515 | |
| GSE53622 | LBR | 3930 | 19987 | -0.1321 | 0.1432 | |
| GSE53624 | LBR | 3930 | 19987 | 0.2307 | 0.0004 | |
| GSE63941 | LBR | 3930 | 201795_at | 0.5823 | 0.2798 | |
| GSE77861 | LBR | 3930 | 201795_at | 0.5681 | 0.0791 | |
| GSE97050 | LBR | 3930 | A_23_P200493 | -0.3283 | 0.3675 | |
| SRP007169 | LBR | 3930 | RNAseq | 0.7853 | 0.0207 | |
| SRP008496 | LBR | 3930 | RNAseq | 0.8021 | 0.0117 | |
| SRP064894 | LBR | 3930 | RNAseq | -0.1479 | 0.4826 | |
| SRP133303 | LBR | 3930 | RNAseq | 0.2204 | 0.3042 | |
| SRP159526 | LBR | 3930 | RNAseq | 0.5004 | 0.2150 | |
| SRP193095 | LBR | 3930 | RNAseq | 0.0983 | 0.4350 | |
| SRP219564 | LBR | 3930 | RNAseq | -0.2576 | 0.4361 | |
| TCGA | LBR | 3930 | RNAseq | 0.0806 | 0.1848 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by LBR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LBR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LBR | 3930 | 11 | 0 | 19 | |
| GSE20123 | LBR | 3930 | 11 | 0 | 19 | |
| GSE43470 | LBR | 3930 | 7 | 1 | 35 | |
| GSE46452 | LBR | 3930 | 3 | 1 | 55 | |
| GSE47630 | LBR | 3930 | 15 | 0 | 25 | |
| GSE54993 | LBR | 3930 | 0 | 6 | 64 | |
| GSE54994 | LBR | 3930 | 16 | 0 | 37 | |
| GSE60625 | LBR | 3930 | 0 | 0 | 11 | |
| GSE74703 | LBR | 3930 | 7 | 1 | 28 | |
| GSE74704 | LBR | 3930 | 5 | 0 | 15 | |
| TCGA | LBR | 3930 | 46 | 3 | 47 |
Total number of gains: 121; Total number of losses: 12; Total Number of normals: 355.
Somatic mutations of LBR:
Generating mutation plots.
Highly correlated genes for LBR:
Showing top 20/773 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LBR | BCL7B | 0.757816 | 3 | 0 | 3 |
| LBR | AEBP2 | 0.749688 | 3 | 0 | 3 |
| LBR | ITPK1 | 0.737055 | 3 | 0 | 3 |
| LBR | TMEM18 | 0.72762 | 3 | 0 | 3 |
| LBR | EIF2AK4 | 0.726253 | 3 | 0 | 3 |
| LBR | NDUFA8 | 0.724078 | 3 | 0 | 3 |
| LBR | TNRC18 | 0.719816 | 3 | 0 | 3 |
| LBR | TRUB1 | 0.709344 | 3 | 0 | 3 |
| LBR | ZMYM4 | 0.700886 | 5 | 0 | 5 |
| LBR | BIVM | 0.698315 | 3 | 0 | 3 |
| LBR | C17orf80 | 0.689891 | 4 | 0 | 3 |
| LBR | SCO1 | 0.688956 | 3 | 0 | 3 |
| LBR | KBTBD6 | 0.688313 | 3 | 0 | 3 |
| LBR | PTPMT1 | 0.683433 | 3 | 0 | 3 |
| LBR | ZNF260 | 0.679209 | 4 | 0 | 3 |
| LBR | FAM76B | 0.678029 | 4 | 0 | 3 |
| LBR | NBPF1 | 0.677275 | 3 | 0 | 3 |
| LBR | PIF1 | 0.676592 | 3 | 0 | 3 |
| LBR | RBMX2 | 0.671256 | 6 | 0 | 5 |
| LBR | IWS1 | 0.671098 | 4 | 0 | 3 |
For details and further investigation, click here
